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J-GLOBAL ID：201801006273333220 Update date: Apr. 07, 2025

Naohiro Terasaka

テラサカナオヒロ | Naohiro Terasaka

Affiliation and department：
Job title： Specially Appointed Associate Professor
Homepage URL (2)： https://nterasaka.wixsite.com/terasaka-lab , https://nterasaka.wixsite.com/terasaka-lab/en

Research field (2)： Evolutionary biology , Biochemistry

Research keywords (10)：カプシドタンパク質 , tRNA , リボソーム , 遺伝暗号 , ペプチド , リボザイム , RNA , ケミカルバイオロジー , 分子進化工学 , 合成生物学

Research theme for competitive and other funds (21)：

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Papers (27)：

Hiroki Murakami, Naohiro Terasaka, Haruo Aikawa, Hiroaki Suga. A versatile method of ribosomal synthesis of peptides containing long chain fatty acids at the N-terminus. Bulletin of the Chemical Society of Japan. 2025
Jinxuan Zhao, Yi Li, Naohiro Terasaka, Haruo Aikawa, Hiroaki Suga. Diversity Scale of Library Matters: Impact of mRNA Library Diversity Scales on the Discovery of Macrocyclic Peptides Targeting a Protein by the RaPID System. ACS Central Science. 2025
Wei Lu, Naohiro Terasaka, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Hiroaki Suga. An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation. Nucleic Acids Research. 2024. 52. 7. 3938-3949
Takashi Miura, Tika R Malla, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Kang Ju Lee, Naohiro Terasaka, C David Owen, Claire Strain-Damerell, Petra Lukacik, et al. Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease. Bulletin of the Chemical Society of Japan. 2024. 97. 5
Shota Nishikawa, Hidenori Watanabe, Naohiro Terasaka, Takayuki Katoh, Kosuke Fujishima. De Novo Single-Stranded RNA-Binding Peptides Discovered by Codon-Restricted mRNA Display. Biomacromolecules. 2023. 25. 1. 355-365

MISC (4)：

寺坂尚紘. 実験室内進化で迫る原始ウイルス形成過程. Viva Origino. 2024. 52. 1
寺坂尚紘, Donald Hilver. 細菌タンパクを用いたウイルス様構造とパッケージング機構の進化. Science に載った日本人研究者 2021. 2022. 34
寺坂尚紘. 細菌タンパク質をウイルス模倣ヌクレオカプシドに分子進化させる. 生化学. 2022. 94. 5
寺坂尚紘. リボソーム翻訳系と修飾酵素を用いた非リボソームペプチド類似体の合成. ファルマシア. 2021. 57. 6. 543-543

Books (5)：

生体分子の実験的進化工学
生体の科学 Vol.76 No.2 2025年 04月号特集 AIにより加速する生体分子デザイン 2025
特殊環状ペプチドライブラリの構築と薬剤候補探索
CSJ Current Review 生体分子と疾患ーヘルスサイエンスの切り札としての化学ー 2021
試験管内分子進化法によるバイオマテリアル創成
日本核酸化学会核酸科学ハンドブック 2020
Applications of aminoacylation ribozymes that recognize the 3’-end of tRNA
Springer 2017
遺伝暗号のリプログラミングによる特殊ペプチドライブラリーの構築と生理活性ペプチド探索
実験医学増刊号 Vol.29 No.7, 75-82 2011

Lectures and oral presentations (87)：

A HIGH-ACCURACY PAIR MATCHING METHOD FOR DROPLET MICROFLUIDICS WITH TWO-STATE MEASUREMENT POINTS
(IEEE MEMS 2025 2025)
Establishment of a platform for the development of novel xCT inhibitors
(The 47th Annual Meeting of the Molecular Biology Society of Japan 2024)
Directed evolution of CO2 fixation enzyme using cell free expression biosensor and droplet sorting
(The 47th Annual Meeting of the Molecular Biology Society of Japan 2024)
A Simple peptide tag inducing protein condensates in cell-free translation system
(4th Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS2024) 2024)
How does library size affect the biding kinetics of hits in RaPID selection?
(4th Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS2024) 2024)

Education (5)：

2012 - 2015 The University of Tokyo Graduate School of Science Department of Chemistry
2010 - 2012 The University of Tokyo The Graduate School of Engineering Department of Chemistry and Biotechnology
2008 - 2010 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
2006 - 2008 The University of Tokyo College of Arts and Sciences
2003 - 2006 駒場東邦高等学校

Professional career (1)：

Work history (8)：

2024/10 - 現在 Institute of Science Tokyo Earth-Life Science Institute, Institute of Future Science Specially Appointed Associate Professor
2021/10 - 現在国立研究開発法人科学技術振興機構さきがけ研究「細胞の動的高次構造体」研究者
2022/06 - 2024/09 Tokyo Institute of Technology International Research Frontiers Initiative, Earth-Life Science Institute Specially Appointed Associated Professor
2022/04 - 2022/06 The University of Tokyo Graduate School of Science Department of Chemistry Assistant professor
2018/06 - 2022/03 The University of Tokyo Graduate School of Science, Department of Chemistry Project Assistant Professor

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Awards (5)：

Association Membership(s) (5)：

The Biophysical Society of Japan , 「細胞を創る」研究会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE RNA SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN

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