The University of North Carolina at Chapel Hill
Eshelman School of Pharmacy
Adjunct A. Professor
Research field (1):
Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (25):
2024 - 2026 難治性乳がん克服を目指した化学生物学的アプローチ
2024 - 2026 インドネシア薬用植物由来メロテルペノイドによる多剤耐性がんの克服
2024 - 2024 フトモモ科Syzygium属含有の機能性成分の探索
2024 - 2024 天然物誘導体による休眠ミトコンドリアを標的としたがん細胞生存戦略への挑戦
2023 - 2024 休眠ミトコンドリアに着目した新規抗がん戦略
2021 - 2023 難治性乳がん克服に向けた化学生物学的アプローチ法の確立と創薬への展開
2019 - 2022 Chemical approaches to understand the complex mechanism of nucleotide excision repair
2019 - 2022 Coffee diterpens inhibit prostate cancer progression
2018 - 2022 Development of novel drug leads based on rare tropical resources
2021 - 2022 希少植物性天然資源の化学的保存
2017 - 2020 The development of the innovative therapeutic drugs which targete crosstalk in the prostate cancer microenvironment
2016 - 2020 Phytochemistry study of Indonesian authigenic and traditional medicinal plants
2016 - 2019 Mechanistic analysis of novel DNA repair inhibitors and their possible application to anticancer therapy
2013 - 2018 Discovery of antitumor drug candidates from rainforest plants
2013 - 2016 Application of chemical biology to a mechanistic study of human nucleotide excision repair
2013 - 2016 Chemical biology of MDR cancer selective cytotoxicity using natural product derivatives
2013 - 天然物由来小分子化合物の多剤耐性癌細胞への選択性誘導
2008 - 2010 Desmosdumotins as Potential New Classes of Antitumor Drug Candidates
2008 - 2009 イミノエン化学と天然物合成への応用研究
1994 - 1994 新規抗ガン性indolo[2,3-a]carbazole化合物群の合成研究
1993 - 1993 薬理活性1-ヒドロキシインドール化合物群の合成と反応
1992 - 1992 薬理活性4位窒素置換benz[cd]indole化合物群の合成研究
1990 - 1990 薬理活性インド-ル化合物群の合成研究
1990 - 1990 2位に置換基を持つ新規な三環性麦角アルカロイド誘導体の合成研究
1988 - 1988 有機金属化合物を利用した環状化合物の新規クロスカップリング反応開拓研
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Papers (133):
Yohei Saito, Tomoya Nishida, Kyoko Nakagawa-Goto. Spiromeroterpenoids from the Higher Plants. Chemical and Pharmaceutical Bulletin. 2025. 73. 3. 138-155
Kanami Watanabe, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Two New Halimanes with a γ-Lactone from Croton argyratus. Chemical & pharmaceutical bulletin. 2025. 73. 3. 162-167
Nona Koga, Kaede Kawashima, Chihiro Ito, Tomoya Nishida, Shuichi Fukuyoshi, Yohei Saito, Katsunori Miyake, Saidanxia Amuti, Abdul Rahim, Ahmad Najib, et al. Spiro-meroterpenoids, Syzygioblanes D-H, Isolated from Indonesian Medicinal Plant Syzygium oblanceolatum. Journal of Natural Products. 2024. 87. 12. 2872-2880
Hayato Kouno, Saidanxia Amuti, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, Masuo Goto, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis. Journal of Natural Products. 2024. 87. 7. 1763-1777
Nona Koga, Yohei Saito, Katsunori Miyake, Saidanxia Amuti, Shuichi Fukuyoshi, Satoshi Yoshida, Sota Sato, Yusuke Yamada, Akihito Ikeda, Naruhiko Adachi, et al. Cyclic Sesquiterpene-Flavanone [4+2] Hybrids, Syzygioblanes A-C, Found in an Indonesian Traditional Medicine, “Jampu Salo” (Syzygium oblanceolatum). Organic Letters. 2024. 26. 20. 4302-4307
An-Shen Lin, Kyoko Nakagawa-Goto, Fang-Rong Chang, Donglei Yu, Susan L. Morris-Natschke, Chin-Chung Wu, Shu-Li Chen, Kuo-Hsiung Lee, Yang-Chang Wu. First total synthesis of protoapigenone and its analogs as potent cytotoxic agents. DRUGS OF THE FUTURE. 2007. 32. 105-105
Patents (8):
Preparation of desmosdumotin C and B and their analogs as antitumor and anti-AIDS agents
4-Aamino-2H-pyran-2-one analogs as anticancer agents and their preparation
Preparation of novel sesquiterpene derivatives and their use in inflammation and cancer treatment
Novel sesquiterpene derivatives and compositions comprising the same for treating inflammation and/or neoplasm related disorders