Goto Kyoko

Affiliation and department：
Other affiliations (1)：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (18)：

2019 - 2022 Chemical approaches to understand the complex mechanism of nucleotide excision repair
2019 - 2022 Coffee diterpens inhibit prostate cancer progression
2018 - 2022 Development of novel drug leads based on rare tropical resources
2017 - 2020 The development of the innovative therapeutic drugs which targete crosstalk in the prostate cancer microenvironment
2016 - 2020 Phytochemistry study of Indonesian authigenic and traditional medicinal plants

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Papers (117)：

Ayano Kobayashi, Yohei Saito, Katsunori Miyake, Shuichi Fukuyoshi, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto. Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora. Journal of natural products. 2024
Takafumi Shimada, Renato Naito, Ren Toriumi, Ryunosuke Nakagawa, Shuhei Aoyama, Taiki Kamijima, Hiroshi Kano, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, et al. Novel α-Trifluoromethyl Chalcone Exerts Antitumor Effects Against Prostate Cancer Cells. Anticancer research. 2023. 43. 6. 2433-2444
Abdul Rahim, Saidanxia Amuti, Ahmad Najib, Katsunori Miyake, Yohei Saito, Kyoko Nakagawa-Goto. A New Bis-indole Alkaloid, Spermaocymine A, and an Anthraquinone from Spermacoce ocymoides. Chemical & pharmaceutical bulletin. 2023. 71. 5. 380-384
Hiroshi Kano, Kouji Izumi, Kaoru Hiratsuka, Ren Toriumi, Ryunosuke Nakagawa, Shuhei Aoyama, Taiki Kamijima, Takafumi Shimada, Renato Naito, Suguru Kadomoto, et al. Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20-CCR6 axis. Cancer science. 2022. 114. 4. 1479-1490
Tomoyuki Makino, Kouji Izumi, Kaoru Hiratsuka, Hiroshi Kano, Takashi Shimada, Taito Nakano, Suguru Kadomoto, Renato Naito, Hiroaki Iwamoto, Hiroshi Yaegashi, et al. Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells. Scientific Reports. 2021. 11. 1. 675-675

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MISC (3)：

Patents (8)：

Preparation of desmosdumotin C and B and their analogs as antitumor and anti-AIDS agents
4-Aamino-2H-pyran-2-one analogs as anticancer agents and their preparation
Preparation of novel sesquiterpene derivatives and their use in inflammation and cancer treatment
Novel sesquiterpene derivatives and compositions comprising the same for treating inflammation and/or neoplasm related disorders
抗がん作用を有するベンゾチオフェン誘導体

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Lectures and oral presentations (9)：

Steppingstone to drug discovery with handcrafted natural products
(The 37th Symposium on Natural Products 2022)
Drug Discovery and Development based on Natural Products
(1st Makassar International Conference in Pharmaceutical Sciences 2021)
薬用生理活性天然物の単離精製・合成・メディシナルケミストリーへの展開
(日本薬学会第140年会シンポジウム "天然物パワー6.アカデミア創薬" 2020)
天然物基本骨格から細胞周期阻害剤の創成
(第129回薬学会北陸支部例会「シンポジウム」がん・免疫 -研究と臨床の最前線- 2017)
Drug discovery and development based on natural products
(Special Seminar in Hasanuddin University 2017)

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Professional career (1)：

Work history (8)：

2012/04 - 現在 University of North Carolina at Chapel Hill Eshelman School of Pharmacy Adjunct Associate Professor
2012/04 - 現在 Kanazawa University School of Pharmaceutical Science/Pharmacy Associate Professor
2011/03 - 2012/03 University of North Carolina at Chapel Hill Eshelman School of Pharmacy Research Associate Professor
2006/08 - 2011/02 University of North Carolina at Chapel Hill Eshelman School of Pharmacy Research Assistant Professor
2002/07 - 2006/07 University of North Carolina at Chapel Hill Eshelman School of Pharmacy Research Associate

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Association Membership(s) (3)：

THE JAPANESE SOCIETY OF PHARMACOGNOSY , THE PHARMACEUTICAL SOCIETY OF JAPAN , American Chemical Society

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