Rchr
J-GLOBAL ID：201801006532272684
Update date: Feb. 01, 2024
Akasaka-Manya Keiko
Akasaka-Manya Keiko
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Affiliation and department：
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
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Research field (2)：
Applied biochemistry
, Functional biochemistry
Research theme for competitive and other funds (4)：
2019 - 2022 Regulatory Mechanism of APP Metabolism by O-Glycosylation
2013 - 2016 Molecular basis of regulation of nerve function by glycosylation
2010 - 2011 糖転移酵素によるAPP代謝調節機構の解析
2007 - 2009 筋ジストロフィー症の発症に関わる糖鎖合成酵素の機能解析とその破綻
Papers (26)：
Nobuaki Miura, Hisatoshi Hanamatsu, Ikuko Yokota, Keiko Akasaka-Manya, Hiroshi Manya, Tamao Endo, Yasuro Shinohara, Jun-Ichi Furukawa. Toolbox Accelerating Glycomics (TAG): Improving Large-Scale Serum Glycomics and Refinement to Identify SALSA-Modified and Rare Glycans. International journal of molecular sciences. 2022. 23. 21
Keiko Akasaka-Manya, Hiroshi Manya. The Role of APP O-Glycosylation in Alzheimer's Disease. Biomolecules. 2020. 10. 11
Jun-Ichi Furukawa, Hisatoshi Hanamatsu, Takashi Nishikaze, Hiroshi Manya, Nobuaki Miura, Hirokazu Yagi, Ikuko Yokota, Keiko Akasaka-Manya, Tamao Endo, Motoi Kanagawa, et al. Lactone-Driven Ester-to-Amide Derivatization for Sialic Acid Linkage-Specific Alkylamidation. Analytical chemistry. 2020. 92. 21. 14383-14392
Keiko Akasaka-Manya, Hiroshi Manya, Satomi Nadanaka, Hiroshi Kitagawa, Yoshitaka Kondo, Akihito Ishigami, Tamao Endo. Decreased ADAM17 expression in the lungs of α-Klotho reduced mouse. Journal of biochemistry. 2020. 167. 5. 483-493
Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saito, Yuriko Tachida, Shinobu Kitazume, Hiroyuki Hatsuta, Yuri Miura, Shin-ichi Hisanaga, Shigeo Murayama, et al. Excess APP O-glycosylation by GalNAc-T6 decreases A beta production. JOURNAL OF BIOCHEMISTRY. 2017. 161. 1. 99-111
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MISC (7)：
赤阪(萬谷)啓子, 灘中里美, 近藤嘉高, 石神昭人, 北川裕之, 萬谷博, 遠藤玉夫. α-Klothoマウス肺で見られるヘパラン硫酸の発現変化. 日本生化学会大会(Web). 2018. 91st
赤阪(萬谷)啓子, 川村方希, 川村方希, 津元裕樹, 萬谷博, 遠藤玉夫. APP代謝におけるppGalNAcT-6の影響. 日本生化学会大会(Web). 2016. 89th
Hiroshi Manya, Takeyuki Yamada, Tetsuo Takahashi, Keiko Akasaka-Manya, Tamao Endo. Functional interaction of POMT and DPM synthase in protein O-mannosylation. GLYCOBIOLOGY. 2014. 24. 11. 1147-1148
赤阪(萬谷)啓子, 萬谷博, 遠藤玉夫. 高齢者の慢性腎臓病 CKD診療ガイドと最近の話題 老化研究の進歩 2)α-Klothoと老化・腎. Geriatric Medicine. 2013. 51. 6
Tamao Endo, Hiroshi Manya, Keiko Akasaka. Congenital muscular dystrophies with abnormal neuronal migration. NEUROSCIENCE RESEARCH. 2008. 61. S18-S18
ｍore...
Books (1)：
Vitamins and Hormones
Elsevier 2016
Professional career (1)：
バイオサイエンス博士 (奈良先端科学技術大学院大学)
Awards (2)：
2018 - JB Award Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production
2011 - Samuro Kakiuchi Memorial Research Award for Young Scientists (by Gushinkai)
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