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J-GLOBAL ID:201801006924329900   Update date: Feb. 07, 2025

Takabatake Yoshitsugu

タカバタケ ヨシツグ | Takabatake Yoshitsugu
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Affiliation and department:
Job title: Associate Professor
Research field  (1): Pathobiochemistry
Research keywords  (5): mTOR ,  proximal tubules ,  lysosome ,  mitochondria ,  autophagy
Research theme for competitive and other funds  (14):
  • 2021 - 2024 転写因子Mondoによる腎近位尿細管オートファジー・エネルギー代謝制御機構の解明
  • 2021 - 2024 早期CKD患者の精密医療を目指した予後評価法の開発
  • 2019 - 2022 Estimation of renal outcome in kidney donors with renal biopsy
  • 2019 - 2022 Lipophagy in AKI: the role and clinical application
  • 2018 - 2021 Lysosomal stress as an emerging target in kidney disease
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Papers (167):
  • Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, et al. Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI insight. 2024
  • Sho Matsui, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Jun Nakamura, et al. Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules. Autophagy. 2024
  • Shihomi Maeda, Shinsuke Sakai, Yoshitsugu Takabatake, Takeshi Yamamoto, Satoshi Minami, Jun Nakamura, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, et al. MondoA and AKI and AKI-to-CKD Transition. Journal of the American Society of Nephrology : JASN. 2024
  • Satoshi Minami, Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, et al. FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity. Autophagy. 2023
  • Shihoko Kimura-Ohba, Yoshitsugu Takabatake, Atsushi Takahashi, Yoko Tanaka, Shinsuke Sakai, Yoshitaka Isaka, Tomonori Kimura. Blood levels of d-amino acids reflect the clinical course of COVID-19. Biochemistry and biophysics reports. 2023. 34. 101452-101452
more...
MISC (48):
  • 松井翔, 山本毅士, 高畠義嗣, 高橋篤史, 難波倫子, 松田潤, 南聡, 酒井晋介, 中村隼, 前田志穂美, et al. エンパグリフロジンはメガリン介在性アルブミン-脂肪酸毒性に伴うオートファジー停滞を解消し腎保護に働く. 日本腎臓学会誌(Web). 2023. 65. 3
  • 山本毅士, 南聡, 酒井晋介, 高橋篤史, 難波倫子, 松田潤, 余西洋明, 中村隼, 前田志穂美, 松井翔, et al. FGF21とオートファジーは協調的に加齢や肥満による腎臓病進展に対抗する. 日本腎臓学会誌(Web). 2023. 65. 3
  • 前田志穂美, 酒井晋介, 山本毅士, 高橋篤史, 難波倫子, 松田潤, 南聡, 中村隼, 松井翔, 島田直幸, et al. MondoAはTFEB活性化を介したミトコンドリア生合成によりAKIからCKDへの進展を抑制する. 日本腎臓学会誌(Web). 2023. 65. 3
  • 松井翔, 山本毅士, 高畠義嗣, 高橋篤史, 難波倫子, 松田潤, 南聡, 酒井晋介, 余西洋明, 中村隼, et al. エンパグリフロジンは脂肪酸毒性軽減とオートファジー停滞解消を介して腎保護に働く. 日本腎臓学会誌(Web). 2022. 64. 3
  • 南聡, 山本毅, 高畠義嗣, 高橋篤史, 難波倫子, 松田潤, 酒井晋介, 中村隼, 前田志穂美, 松井翔, et al. 近位尿細管におけるp53とオートファジーはSASP(老化関連分泌表現型)を協調的に抑制し腎老化を抑制する. 日本腎臓学会誌(Web). 2022. 64. 3
more...
Professional career (1):
  • 医学博士 (大阪大学)
Work history (1):
  • 2001/04 - 現在 Osaka University Graduate School of Medicine Department of Nephrology
Association Membership(s) (3):
THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  THE JAPANESE SOCIETY FOR DIALYSIS THERAPY ,  JAPANESE SOCIETY OF NEPHROLOGY
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