2013 - 2016 Environmental conditions control nucleolar signaling to regulate ribosomal RNA transcription by KDM2A (K-specific demethylase)
2011 - 2012 Molecular mechanism of repression of rDNA transcription by KDM2A in response to starvation
2007 - 2008 新規ヒストン脱メチル化蛋白質によるリボソームRNA遺伝子のクロマチンの調節
Papers (19)：
Yuji Tanaka, Makoto Tsuneoka. Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation. Biomolecules. 2021
Yuji Tanaka, Hideru Obinata, Akimitsu Konishi, Noriyuki Yamagiwa, Makoto Tsuneoka. Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription. Cells. 2020. 9. 10. 2266-2266
Yuji Tanaka, Akimitsu Konishi, Hideru Obinata, Makoto Tsuneoka. Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level. SCIENTIFIC REPORTS. 2019. 9. 1. 18694-18694
Kengo Okamoto, Yuji Tanaka, Sachiko Ogasawara, Chikashi Obuse, Jun-Ichi Nakayama, Hirohisa Yano, Makoto Tsuneoka. KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells. Oncotarget. 2019. 10. 46. 4743-4760
Yuji Tanaka, Makoto Tsuneoka. Control of Ribosomal RNA Transcription by Nutrients. Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics. 2018
