2019 - 2021 Generation of a pig model for the diabetic nephropathy using gene editing technology
2018 - 2021 Production of immunodeficient micro-mini pig using genome editing technology.
2017 - 2020 Production of genetically modified pigs by combined techniques of chromosome engineering and genome editing
2017 - 2019 Production of pigs for safe xenotransplantation by controlling infectious porcine endogenous retrovirus (PERV)
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Papers (112):
Nanaka Torigoe, Qingyi Lin, Bin Liu, Yuichiro Nakayama, Aya Nakai, Megumi Nagahara, Fuminori Tanihara, Maki Hirata, Takeshige Otoi. Effects of Electroporation Timing and Cumulus Cell Attachment on In Vitro Development and Genome Editing of Porcine Embryos. Reproduction in domestic animals = Zuchthygiene. 2025. 60. 2. e70011
Qingyi Lin, Koki Takebayashi, Nanaka Torigoe, Bin Liu, Zhao Namula, Maki Hirata, Fuminori Tanihara, Megumi Nagahara, Takeshige Otoi. Genome editing of porcine zygotes via lipofection of two guide RNAs using a CRISPR/Cas9 system. The Journal of reproduction and development. 2024. 70. 6. 356-361
Qingyi Lin, Nanaka Torigoe, Bin Liu, Yuichiro Nakayama, Aya Nakai, Zhao Namula, Megumi Nagahara, Fuminori Tanihara, Maki Hirata, Takeshige Otoi. Efficient gene editing of pig embryos by combining electroporation and lipofection. Veterinary world. 2024. 17. 11. 2701-2707
Koki Takebayashi, Manita Wittayarat, Maki Hirata, Qingyi Lin, Zhao Namula, Nanaka Torigoe, Bin Liu, Megumi Nagahara, Aya Nakai, Takeshige Otoi, et al. Optimization of embryonic stage for aggregation to generate chimeric pigs using gene-edited blastomeres. In vitro cellular & developmental biology. Animal. 2024
Thanh-Van Nguyen, Koki Takebayashi, Lanh Thi Kim Do, Zhao Namula, Manita Wittayarat, Megumi Nagahara, Maki Hirata, Takeshige Otoi, Fuminori Tanihara. Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs. In vitro cellular & developmental biology. Animal. 2024. 60. 7. 708-715
K. Kikuchi, N. V. Linh, M. Nakai, F. Tanihara, J. Noguchi, H. Kaneko, T. Q. Dang-Nguyen, N. T. Men, N. Van Hanh, T. Somfai, et al. Fusion of cytoplasmic fragments to porcine oocytes improves the ability for embryonic development. REPRODUCTION IN DOMESTIC ANIMALS. 2012. 47. 451-451
F. Tanihara, M. Nakai, H. Kaneko, J. Noguchi, T. Otoi, K. Kikuchi. Effects of the zona pellucida on in vitro sperm penetration into porcine oocytes. REPRODUCTION IN DOMESTIC ANIMALS. 2012. 47. 513-514
V. V. Luu, Z. Namula, Y. Kaedei, F. Tanihara, T. Otoi. EFFECTS OF OVARY STORAGE TIME ON THE QUALITY AND MEIOTIC COMPETENCE OF CAT OOCYTES. REPRODUCTION FERTILITY AND DEVELOPMENT. 2012. 24. 1. 205-206
中井美智子, 伊藤潤哉, 柏崎直巳, 谷原史倫, 野口純子, 金子浩之, 菊地和弘, 菊地和弘. PKC活性化がブタ卵細胞質内精子注入卵の受精および胚発生に及ぼす影響. Journal of Reproduction and Development. 2011. 57. Suppl Japanese Issue
THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, SOCIETY FOR REPRODUCTION AND DEVELOPMENT
, International Society for Transgenic Technologies
, 日本異種移植研究会
, 日本ゲノム編集学会
, 日本獣医学会