2019 - 2021 Generation of a pig model for the diabetic nephropathy using gene editing technology
2018 - 2021 Production of immunodeficient micro-mini pig using genome editing technology.
2017 - 2020 Production of genetically modified pigs by combined techniques of chromosome engineering and genome editing
2017 - 2019 Production of pigs for safe xenotransplantation by controlling infectious porcine endogenous retrovirus (PERV)
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Papers (102):
Fuminori Tanihara, Maki Hirata, Zhao Namula, Manita Wittayarat, Lanh Thi Kim Do, Qingyi Lin, Koki Takebayashi, Hiromasa Hara, Megumi Nagahara, Takeshige Otoi. GHR-mutant pig derived from domestic pig and microminipig hybrid zygotes using CRISPR/Cas9 system. Molecular biology reports. 2023. 50. 6. 5049-5057
Thanh Van Nguyen, Lanh Thi Kim Do, Zhao Namula, Qingyi Lin, Nanaka Torigoe, Megumi Nagahara, Maki Hirata, Fuminori Tanihara, Takeshige Otoi. DEVELOPMENT AND GENOME MUTATION OF BOVINE ZYGOTES VITRIFIED BEFORE AND AFTER GENOME EDITING VIA ELECTROPORATION. Cryo-Letters. 2023. 44. 2. 118-122
Chommanart Thongkittidilok, Maki Hirata, Qingyi Lin, Nanaka Torigoe, Bin Liu, Yoko Sato, Megumi Nagahara, Fuminori Tanihara, Takeshige Otoi. Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study. Veterinary medicine international. 2023. 2023. 7000858-7000858
Fuminori Tanihara, Maki Hirata, Zhao Namula, Lanh Thi Kim Do, Naoaki Yoshimura, Qingyi Lin, Koki Takebayashi, Tetsushi Sakuma, Takashi Yamamoto, Takeshige Otoi. Pigs with an INS point mutation derived from zygotes electroporated with CRISPR/Cas9 and ssODN. Frontiers in cell and developmental biology. 2023. 11. 884340
Fuminori Tanihara, Maki Hirata, Takeshige Otoi. GEEP Method: An Optimized Electroporation-Mediated Gene Editing Approach for Establishment of Knockout Pig Lines. Methods in molecular biology (Clifton, N.J.). 2023. 2637. 293-300
K. Kikuchi, N. V. Linh, M. Nakai, F. Tanihara, J. Noguchi, H. Kaneko, T. Q. Dang-Nguyen, N. T. Men, N. Van Hanh, T. Somfai, et al. Fusion of cytoplasmic fragments to porcine oocytes improves the ability for embryonic development. REPRODUCTION IN DOMESTIC ANIMALS. 2012. 47. 451-451
F. Tanihara, M. Nakai, H. Kaneko, J. Noguchi, T. Otoi, K. Kikuchi. Effects of the zona pellucida on in vitro sperm penetration into porcine oocytes. REPRODUCTION IN DOMESTIC ANIMALS. 2012. 47. 513-514
V. V. Luu, Z. Namula, Y. Kaedei, F. Tanihara, T. Otoi. EFFECTS OF OVARY STORAGE TIME ON THE QUALITY AND MEIOTIC COMPETENCE OF CAT OOCYTES. REPRODUCTION FERTILITY AND DEVELOPMENT. 2012. 24. 1. 205-206
中井美智子, 伊藤潤哉, 柏崎直巳, 谷原史倫, 野口純子, 金子浩之, 菊地和弘, 菊地和弘. PKC活性化がブタ卵細胞質内精子注入卵の受精および胚発生に及ぼす影響. Journal of Reproduction and Development. 2011. 57. Suppl Japanese Issue
THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, SOCIETY FOR REPRODUCTION AND DEVELOPMENT
, International Society for Transgenic Technologies
, 日本異種移植研究会
, 日本ゲノム編集学会
, 日本獣医学会