Takashi Kanaya

Affiliation and department：

Research field (1)： Immunology

Research theme for competitive and other funds (8)：

2022 - 2026 食物繊維が小腸免疫系を発達させる仕組みの解明
2019 - 2022 The role of Peyer's patch dendritic cells and macropahges in regulation of mucosal immune responses
2016 - 2019 Differentiation and function of M cells, a unique intestinal epithelial cell subset for untigen uptake
2015 - 2017 パイエル板濾胞随伴上皮(FAE)の機能制御を行う微小環境の解明
2014 - 2017 The role of NF-kB signaling in intestinal homeostasis

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Papers (41)：

Tadashi Takeuchi, Keishi Kameyama, Eiji Miyauchi, Yumiko Nakanishi, Takashi Kanaya, Takayoshi Fujii, Tamotsu Kato, Takaharu Sasaki, Naoko Tachibana, Hiroki Negishi, et al. Fatty acid overproduction by gut commensal microbiota exacerbates obesity. Cell metabolism. 2023. 35. 2. 361-375
Tadashi Takeuchi, Eiji Miyauchi, Takashi Kanaya, Tamotsu Kato, Yumiko Nakanishi, Takashi Watanabe, Toshimori Kitami, Takashi Taida, Takaharu Sasaki, Hiroki Negishi, et al. Acetate differentially regulates IgA reactivity to commensal bacteria. Nature. 2021. 595. 7868. 560-564
Takashi Kanaya, Ifor R Williams, Hiroshi Ohno. Intestinal M cells: Tireless samplers of enteric microbiota. Traffic (Copenhagen, Denmark). 2020. 21. 1. 34-44
Megan L Stanifer, Markus Mukenhirn, Stephanie Muenchau, Kalliopi Pervolaraki, Takashi Kanaya, Dorothee Albrecht, Charlotte Odendall, Thomas Hielscher, Volker Haucke, Jonathan C Kagan, et al. Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells. Nature microbiology. 2020. 5. 1. 181-191
Shunsuke Kimura, Nobuhide Kobayashi, Yutaka Nakamura, Takashi Kanaya, Daisuke Takahashi, Ryoji Fujiki, Mami Mutoh, Yuuki Obata, Toshihiko Iwanaga, Tomoo Nakagawa, et al. Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice. The Journal of experimental medicine. 2019. 216. 4. 831-846

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MISC (7)：

Megan Stanifer, Dorothee Albrecht, Sina Bartfeld, Jonathan Kagan, Takashi Kanaya, Steeve Boulant. Polarized interferon-mediated immune response against enteric pathogens reveal novel mechanisms of immune tolerance in the human gut. CYTOKINE. 2017. 100. 39-40
Innate immune pathways of the intestinal epithelium protecting against infection and tumourigenesis. 2016. 66. 3. 294-300
柳原沙恵, 福田真嗣, 金谷高史, 弘田辰彦, 山本直之, 大野博司. Lactobacillus acidophilus L-92の表層蛋白質が小腸パイエル板のM細胞からの取り込みに与える影響. 日本乳酸菌学会誌. 2016. 27. 2. 130-130
D. S. Donaldson, A. Kobayashi, C. Erridge, T. Kanaya, I. R. Williams, H. Ohno, A. Mahajan, N. A. Mabbott. Aging impairs the functional maturation of M cells and their ability to sample lumenal antigens. IMMUNOLOGY. 2013. 140. 37-37
Transcription factors involved in M-cell differentiation. 2013. 60. 1. 83-89

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Patents (3)：

Education (2)：

Professional career (1)：

Work history (5)：

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