Tokai University School of Medicine
Neurodegenerative diseases, Motor neuron diseases, iPSCs, GEF, Small G proteins, Rab, Golgi apparatus, amphisome, Early endosome, ALS2, ALS
2020 - 2023 A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier
2020 - 2023 A hydrogen isotope separation method based on the Ludwig-Soret effect
2020 - 2023 Imaging device development for hyperpolarization response analysis forming neural activity rhythm
2019 - 2023 An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS
2018 - 2023 Ensuring integrity of gametogenesis
2018 - 2023 Establishment of in vitro spermatogenesis with high integrity
2018 - 2023 An integrated body-on-a-chip mimicking physiological parameters
2013 - 2018 In vitro system maintaining efficient spermatogenesis for a long duration
2015 - 2017 Development of an On-chip Simulator of Hepatic Lobule
2014 - 2017 Development of in vitro embryo culture system based-on microfluidics for artificial reproductive technology
2014 - 2017 Ischemic stroke therapy using quality and quantity-controlled culture system enriched in endothelial progenitor cells
2013 - 2015 細胞間相互作用の解明に向けたマイクロ流体プローブ集積型アッセイツールの構築
2009 - 2015 Behavioral analyses of genes and cells in early mammalian development
2012 - 2014 An on-chip hepatic metabolism model for pharmacokinetic studies
2010 - 2011 マイクロ流体技術を応用した哺乳類胚アッセイプラットフォームの構築
2010 - 2011 Integrated "Body on a Chip" system for cell-based assay
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Papers (95):
Maki Kamoshita, Hiroki Shirai, Hiroko Nakamura, Tetsuya Kishimoto, Yuki Hatanaka, Daisuke Mashiko, Katsuhiro Esashika, Jingjing Yang, Satoshi Yamasaki, Takehiko Ogawa, et al. Development of the membrane ceiling method for in vitro spermatogenesis. Scientific Reports. 2025. 15. 1
Naoaki Okabayashi, Katsuki Hirai, Takayuki Nagata, Kazuhide Makiyama, Junichi Matsuzaki, Kota Fukuda, Shun Takahashi, Mitsuru Komeya, Hiroshi Kimura. Discrete element method-based simulation system for predicting natural stone evacuation pathways in patients with urolithiasis. Computers in Biology and Medicine. 2025. 184. 109454-109454
Tomoki Imaoka, Reiko Onuki-Nagasaki, Hiroshi Kimura, Kempei Tai, Mitsuharu Ishii, Ayaka Nozue, Ikuko Kaisaki, Misa Hoshi, Kengo Watanabe, Kazuya Maeda, et al. Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut. Scientific Reports. 2024. 14. 1
Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, Fumiya Tokito, Takuma Kobayashi, Dhimas Agung Kurniawan, Hiroki Shioda, Wenxin Cao, Kenta Shinha, Hiroko Nakamura, et al. Advancements in Microphysiological Systems: Exploring Organoids and Organ-on-a-Chip Technologies in Drug Development -Focus on Pharmacokinetics Related Organs-. Drug Metabolism and Pharmacokinetics. 2024. 101046-101046
Jin Hong Yap, Hong Zhang, Yosuke Okamura, Hiroshi Kimura. Thin microporous polydimethylsiloxane membrane prepared by phase separation and its applications for cell culture. Materialia. 2024. 38. 102247-102247
村上裕太, WANG Bingbing, 西島恵子, 大友麻子, 大友麻子, 秦野伸二, 秦野伸二, 木村啓志, 木村啓志. Fabrication and evaluation of microfluidic devices suitable for co-culture of human iPSCs-derived neurons. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
THE SOCIETY OF INSTRUMENT AND CONTROL ENGINEERS
, THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN
, THE SOCIETY FOR CHEMISTRY AND MICRO-NANO SYSTEMS
, THE JAPAN SOCIETY OF MECHANICAL ENGINEERS
, 日本動物実験代替法学会