Ohshima Yasuhiro

オオシマヤスヒロ | Ohshima Yasuhiro

Affiliation and department：

Research field (4)： Pharmaceuticals - health and biochemistry , Tumor diagnostics and therapeutics , Tumor diagnostics and therapeutics , Radiology

Research theme for competitive and other funds (13)：

2022 - 2025 Establishment of a method for controlling the intensity of radiation cytotoxicity by controlling purine receptor activity
2021 - 2024 New diagnostic and therapeutic strategy for organ fibrosis: Radionuclide ablation of active fibroblasts
2020 - 2024 The new strategy for radioresistance in cancer associated with p53 mutation using targeted alpha therapy
2021 - 2024 Investigation of the function of a deubiquitinase, Otub1 on the targeted alpha-radionuclide therapy
2016 - 2019 がん幹細胞及びがん細胞を標的とするα線放出核種を用いた膵がんの新規治療法開発

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Papers (42)：

Shigeki Watanabe, Yuto Kondo, Ichiro Sasaki, Yasuhiro Ohshima, Hiroyuki Kimura, Noriko S. Ishioka. Copper-mediated astatination of 211At-labelled prostate-specific membrane antigen probes in the presence of basic salts. Tetrahedron. 2024. 133920-133920
Yasuhiro Ohshima, Ichiro Sasaki, Shigeki Watanabe, Tetsuya Sakashita, Tatsuya Higashi, Noriko S. Ishioka. Organic cation transporter 3 mediates the non-norepinephrine transporter driven uptake of meta-[211At]astato-benzylguanidine. Nuclear Medicine and Biology. 2022. 112-113. 44-51
Yuto Kondo, Hiroyuki Kimura, Ichiro Sasaki, Shigeki Watanabe, Yasuhiro Ohshima, Yusuke Yagi, Yasunao Hattori, Manami Koda, Hidekazu Kawashima, Hiroyuki Yasui, et al. Copper-mediated radioiodination and radiobromination via aryl boronic precursor and its application to 125I/77Br-labeled prostate-specific membrane antigen imaging probes. Bioorganic & Medicinal Chemistry. 2022. 69. 116915-116915
Ayaka Kanai, Hirofumi Hanaoka, Aiko Yamaguchi, Isa Mahendra, Citra Palangka, Yasuhiro Ohshima, Tetsuya Higuchi, Yoshito Tsushima. Enhancing the accumulation level of 3-[18F]fluoro-L-α-methyltyrosine in tumors by preloading probenecid. Nuclear Medicine and Biology. 2022. 104-105. 47-52
Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, et al. Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy. EJNMMI Physics. 2021. 8. 1. 80-80

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MISC (9)：

坂下哲哉, 松本翔二郎, 渡辺茂樹, 花岡宏史, 大島康宏, 生駒洋子, 右近直之, 東達也, 樋口徹也, 対馬義人, et al. RAP線量変換法の%ID/gの1回測定に関する基礎的検討. 核医学(Web). 2021. 58. Supplement
坂下哲哉, 渡辺茂樹, 花岡宏史, 大島康宏, 生駒洋子, 右近直之, 佐々木一郎, 東達也, 樋口徹也, 対馬義人, et al. Basic study of the RAP method as a patient-friendly dose evaluation for targeted alpha-nuclide therapy. アイソトープ・放射線研究発表会(Web). 2021. 58th
Yasuhiro Ohshima, Yusuke Yagi, Xinyu Chen, Saskia Muhlig, Hiroshi Fushiki, Yoshihiro Murakami, Takahiro Higuchi. In vitro characterization of a novel PET tracer for fatty acid oxidation, F-18-AS3504073-00. JOURNAL OF NUCLEAR MEDICINE. 2020. 61
坂下哲哉, 渡辺茂樹, 花岡宏史, 大島康宏, 生駒洋子, 右近直之, 佐々木一郎, 東達也, 樋口徹也, 対馬義人, et al. ¹³¹I-MIBGの体内動態に着目した²¹¹At-MABGの線量評価シミュレーション. 核医学(Web). 2020. 57. Supplement
石岡典子, 渡辺茂樹, 大島康宏, 坂下哲哉, 河地有木. 最新トピックスから探る核医学の現在と未来 Theranosticsに向けた研究開発の最新トピックス 1.日本発α線放出核種を用いたがん治療薬剤の開発-製造からイメージングまで. Innervision. 2018. 33. 11

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Patents (1)：

放射性フッ素標識化合物

Lectures and oral presentations (4)：

ドイツヴュルツブルク大学病院核医学講座への留学を終えて
(令和2年度東京RBC新春放談会 2021)
Development of meta-[211At]astatobenzylguanidine -basic study with pheochromocytoma model-
(2018)
α線放出211Atを利用した悪性褐色細胞腫治療薬メタアスタトベンジルグアニジン(MABG)の開発
(第13回日本分子イメージング学会 2018)
悪性褐色細胞腫に対するα核種標識meta-[211At]-astato-benzylguanidine (211At-MABG)の開発と基礎的検討
(第35回臨床画像診断懇話会 2016)

Education (1)：

2007 - 2010 Tokyo University of Science Graduate School of Pharmaceutical Sciences Pharmaceutical Life Sciences (Doctoral course)

Work history (5)：

2020/07 - 現在 National Institutes for Quantum and Radiological Science and Technology
2018/12 - 2020/11 University Hospital Wuerzburg Department of Nuclear Medicine
2016/04 - 2020/06 National Institutes for Quantum and Radiological Science and Technology Quantum Beam Science Research Directorate Senior Researcher
2013/04 - 2016/03 Japan Atomic Energy Agency Quantum Beam Science Directorate Researcher
2010/04 - 2013/03 Japan Atomic Energy Agency Quantum Beam Science Directorate Postdoctoral fellowship

Awards (3)：

2017/07 - 量子科学技術研究開発機構研究開発功績賞特賞
2012/06 - 第14回放射線プロセスシンポジウム実行委員会最優秀賞
2010/11 - (一社)日本原子力学会関東・甲越支部奨励賞

Association Membership(s) (2)：

JAPANESE SOCIETY OF NUCLEAR MEDICINE , THE JAPANESE CANCER ASSOCIATION

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