Rchr
J-GLOBAL ID：201801009106935187   Update date: Sep. 03, 2024

Takeshi Marumo

Takeshi Marumo
Affiliation and department：
International University of Health and Welfare

About International University of Health and Welfare


Research field  (1)： Nephrology
Research keywords  (5)： DNAメチル化 ,  エピジェネティクス ,  慢性腎臓病 ,  高血圧 ,  糖尿病性腎症
Research theme for competitive and other funds  (20)：
  • 2023 - 2026 The mechanisms for renal protection by klotho protein supplementation
  • 2021 - 2024 腎臓障害をきたすNAD合成系異常における エピジェネティクスの役割解明
  • 2020 - 2023 クロト蛋白補充による腎保護についての研究
  • 2020 - 2023 Exploration of epigenetic mechanisms underlying development of life style-related disease
  • 2020 - 2022 Integrative elucidation of lifestyle diseases using the epigenomic memory of kidney cells
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Papers (53)：
  • Takeshi Marumo, Naoto Yoshida, Noriko Inoue, Masayuki Yamanouchi, Yoshifumi Ubara, Shinji Urakami, Takeshi Fujii, Yutaka Takazawa, Kenichi Ohashi, Wakako Kawarazaki, et al. Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes. American journal of physiology. Renal physiology. 2024. 327. 3. F397-F411
  • Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Yoshifumi Kurosaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi. Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney. Kidney & blood pressure research. 2023
  • Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Wakako Kawarazaki, Shigeyoshi Oba, Takeshi Marumo, Atsu Aiba, Toshiro Fujita. Rac1 deficiency impairs postnatal development of the renal papilla. Scientific reports. 2022. 12. 1. 20310-20310
  • Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Hiroyuki Kobori, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Akira Nishiyama, Naohito Ishii, Matsuhiko Hayashi. Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy. Journal of Hypertension. 2021. 39. 8. 1567-1576
  • Daigoro Hirohama, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Wakako Kawarazaki, Wataru Fujii, Shigeyoshi Oba, Shigeru Shibata, Takeshi Marumo, Toshiro Fujita. Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded db/db Mice. Hypertension. 2021. 78. 1. 82-93
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MISC (63)：
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Lectures and oral presentations  (59)：
  • The mineralocorticoid receptor antagonist Finerenone limits podocyte injury in high-salt loaded db/db mice
    (ASN Kidney Week 2019 2019)
  • Urinary kidney-specific DNA methylation signature correlates with renal function decline in diabetes
    (ASN Kidney Week 2019 2019)
  • エピジェネティック尿検査による糖尿病性腎症悪化の診断
    (日本高血圧学会総会プログラム・抄録集 2019)
  • 加齢に伴う食塩感受性高血圧発症機序の解明
    (日本高血圧学会総会プログラム・抄録集 2019)
  • 慢性腎臓病に関わるエピジェネティクスと臨床応用への展望
    (第62回日本腎臓学会学術総会シンポジウム 2019)
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Education (2)：
  • 1990 - 1994 慶應義塾大学大学院博士課程医学研究科内科学
  • - 1990 Keio University School of Medicine
Professional career (1)：
  • 博士(医学) (慶應義塾大学)
Work history (8)：
  • 2020/04 - 現在 International University of Health and Welfare Department of Pharmacology, School of Medicine
  • 2020/01 - 2020/03 International University of Health and Welfare Center for Basic Medical Research
  • 2015/05 - 2019/12 The University of Tokyo Research Center for Advanced Science and Technology
  • 2012/12 - 2015/04 The University of Tokyo Research Center for Advanced Science and Technology
  • 2011/11 - 2012/11 Kyorin University Faculty of Medicine
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Awards (3)：
  • 2014 - 腎疾患と高血圧研究会優秀研究賞
  • 2004 - 日本心脈管作動物質学会賞
  • 1999 - 日本心血管内分泌学会若手研究奨励賞
Association Membership(s) (8)：
THE JAPAN DIABETES SOCIETY ,  The Japan Endocrine Society ,  THE JAPANESE SOCIETY FOR DIALYSIS THERAPY ,  日本高血圧学会 ,  American Society of Nephrology ,  JAPANESE SOCIETY OF NEPHROLOGY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  日本薬理学会
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