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J-GLOBAL ID：201801009630138111 Update date: Mar. 22, 2025

Kawashima Akihiro

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Research field (1)： Obstetrics and gynecology

Research theme for competitive and other funds (12)：

2024 - 2027 Elucidation of the pathogenasis and the development of prevention and treatment of preeclampsia through genetic analysis of aspirin resistance
2021 - 2024 Epigenetic Approaches for the Elucidation of Preeclampsia Development Mechanisms in Primary Placenta
2020 - 2023 母体血漿中DNA/RNAを用いた妊娠高血圧症候群の予知法の開発
2018 - 2022 The exploration of exosome involvement in skeletal abnormalities induced by dysregulation of zinc homeostasis
2019 - 2021 Development of the fetal therapy using maternal adipose-derived stem cells

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Papers (49)：

田中紗英子, 向井勇貴, 山下有加, 関根愛子, 瀧田寛子, 新垣達也, 金子真由美, 川嶋章弘, 松岡隆, 関沢明彦, et al. 先天性フィブリノゲン異常症合併妊娠の1例. 東京産科婦人科学会会誌. 2024. 73. 3. 604-608
湊怜子, 上野山麻水, 野田真友子, 平林歩, 松本志穂, 安藤有里子, 上野悠太, 郷田朋子, 佐藤奈加子, 川嶋章弘, et al. Endometrial cancer suspected with Lynch syndrome: a case report. 東京産科婦人科学会会誌. 2024. 73. 1. 68-73
川嶋章弘, 関沢明彦. 妊娠初期母体血漿中cell-free DNAのメチル化異常をマーカーとした妊娠高血圧腎症の発症予知法および病勢の評価法の開発. 東京産婦人科医会誌. 2023. 56. 75-80
Asuka Hori, Hiroko Ogata-Kawata, Aiko Sasaki, Ken Takahashi, Kosuke Taniguchi, Ohsuke Migita, Akihiro Kawashima, Aikou Okamoto, Akihiko Sekizawa, Haruhiko Sago, et al. Improved library preparation protocols for amplicon sequencing-based noninvasive fetal genotyping for RHD-positive D antigen-negative alleles. BMC research notes. 2021. 14. 1. 380-380
川嶋章弘, 関沢明彦. 母体脂肪由来間葉系幹細胞を用いたダウン症胎児に対する幹細胞治療法の開発. 東京産婦人科医会誌. 2021. 54. 95-101

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MISC (41)：

Yamashita Yuka, Matsuoka Ryu, Koide Keiko, Makino Koki, Goto Minako, Takita Hiroko, Arakaki Tatsuya, Tokunaka Mayumi, Kawashima Akihiro, Matsuura Rei, et al. fms様チロシンキナーゼ受容体-1/胎盤成長因子比を用いた妊娠低月齢症例の重症度予測(Predicting severity of small for gestational age cases using fms-like tyrosine kinase receptor-1/placental growth factor ratio). 日本産科婦人科学会雑誌. 2024. 76. 臨増. S-325
Kawashima Akihiro, Iwahashi Masayuki, Tokunaka Mayumi, Sekizawa Akihiko. Adora2bのノックダウンにより胎盤幹細胞におけるフェロトーシスが促進される(Knockdown of Adora2b accelerates ferroptosis in placental stem cells). 日本産科婦人科学会雑誌. 2023. 75. 臨増. S-168
Kawashima Akihiro, Sekizawa Akihiko. 妊娠高血圧腎症を発症した女性の妊娠初期胎盤における遺伝子プロモーターのDNAメチル化の違い(Differential DNA methylation of gene promoters in 1st trimester placentas of women developing preeclampsia). The Journal of Obstetrics and Gynaecology Research. 2021. 47. 8. 2914-2915
Kawashima Akihiro, Sekizawa Akihiko. 妊娠高血圧腎症を発症した女性の妊娠初期胎盤における遺伝子プロモーターのDNAメチル化の違い(Differential DNA methylation of gene promoters in 1st trimester placentas of women developing preeclampsia). 日本産科婦人科学会雑誌. 2021. 73. 臨増. S-247
Kawashima Akihiro, Sekizawa Akihiko. 間葉系幹細胞由来神経前駆細胞のオルガノイドを用いた子宮内移植の特異的な経験的モデル(A unique empirical model of in utero transplantation using organoid of mesenchymal stem cell-derived neural progentior). The Journal of Obstetrics and Gynaecology Research. 2020. 46. 8. 1479-1479

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Books (15)：

【正常を確認し異常への対応を究める! 妊婦健診と保健指導パワーアップガイド妊娠期別ガイド】妊娠初期(〜妊娠13週6日) 随時血糖・50gGCT・75gOGTT(1)
(株)メディカ出版 2021 ISBN:9784840472890
【正常を確認し異常への対応を究める! 妊婦健診と保健指導パワーアップガイド妊娠期別ガイド】妊娠中期(妊娠14週0日〜27週6日) 随時血糖・50gGCT・75gOGTT(2)
(株)メディカ出版 2021 ISBN:9784840472890
【正常の確認と異常への対応を究める! 妊婦健診と保健指導パーフェクトブック妊娠期別ガイド】(第1部)ローリスク妊娠編妊娠初期(〜12週未満) 随時血糖・50g糖負荷試験・75g経口糖負荷試験(1)
(株)メディカ出版 2016 ISBN:9784840454865
【正常の確認と異常への対応を究める! 妊婦健診と保健指導パーフェクトブック妊娠期別ガイド】(第1部)ローリスク妊娠編妊娠中期(12〜24週未満) 随時血糖・50g糖負荷試験・75g経口糖負荷試験(2)
(株)メディカ出版 2016 ISBN:9784840454865
【正常の確認と異常への対応を究める! 妊婦健診と保健指導パーフェクトブック妊娠期別ガイド】(第1部)ローリスク妊娠編妊娠後期(24〜36週未満) 随時血糖・50g糖負荷試験・75g経口糖負荷試験(3)
(株)メディカ出版 2016 ISBN:9784840454865

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Lectures and oral presentations (121)：

Early onset preeclampsia is associated with altered DNA methylation in the first trimester villi
(2024 Annual Congress of Taiwan Association of Obstetrics and Gynecology 2024)
初期胎盤形成時に合胞体化するCytotrophoblastsの細胞膜変化:Arraytomography法による電子顕微鏡的検証
(日本解剖学会総会・全国学術集会抄録集(CD-ROM) 2024)
Characteristics of cases requiring uterine artery embolization for postpartum hemorrhage
(超音波医学 Supplement 2024)
A case of refractory RPOC (Retained products of conception) requiring repeat uterine artery embolization and hysteroscopic surgery
(超音波医学 Supplement 2024)
A Study of the usefulness of conservative management of RPOC (Retained Products of Conception)
(超音波医学 Supplement 2024)

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Education (2)：

2013 - 2016 Showa university Graduate School of Medicine
1999 - 2005 National Defense Medical College faculty of medicine Department of medicine

Work history (4)：

2023/10 - 現在 Showa University
2023/01 - 2023/10 NTT東日本関東病院主任医長
2019/04 - 2022/12 Showa University Department of obstetrics and gynaecology
2016/04 - 2019/03 Showa University

Awards (3)：

2019/04 - Japan JSOG Congress Award The engraftment potential of maternal adipose-derived stem cells, for fetal transplantation
2015/04 - Journal of Gynecology and Obstetrics Research JOGR Best reviewer award
2015/03 - 昭和大学上條賞(大学院)

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