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Rchr

J-GLOBAL ID：201801010717402565 Update date: Apr. 16, 2025

Daisuke Takahashi

Research field (2)： Immunology , Cell biology

Research keywords (5)： Butyric acid , IEL , IEC , Mucosal Immunology , Treg

Research theme for competitive and other funds (5)：

2023 - 2025 腸内細菌を自己として認識するγδT17細胞による宿主-腸内細菌共生関係構築
2020 - 2025 ケミカルバイオロジーを利用した濾胞制御性T細胞分化機序の解明
2017 - 2020 腸内細菌が産生する酪酸による関節リウマチ抑制メカニズムの解明
2015 - 2017 腸上皮と上皮間リンパ球の相互作用に基づく粘膜上皮層免疫システムの成立機構の解析
2011 - 2013 上皮細胞特有の膜タンパク質輸送が腸管粘膜面の生体防御に果たす役割と分子機構の解明

Papers (38)：

Ryohtaroh Matsumoto, Kosuke Ogata, Daisuke Takahashi, Yusuke Kinashi, Takahiro Yamada, Ryo Morita, Keisuke Tanaka, Kouya Hattori, Mayumi Endo, Yumiko Fujimura, et al. AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine. Cellular and Molecular Life Sciences. 2024. 81. 1
Sumika Osa, Yuki Enoki, Daisuke Takahashi, Victor Tuan Giam Chuang, Kazuaki Taguchi, Kazuaki Matsumoto. T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy. FEBS Letters. 2024
Yusuke Kinashi, Keisuke Tanaka, Shunsuke Kimura, Masato Hirota, Seiga Komiyama, Tomoko Shindo, Akinori Hashiguchi, Daisuke Takahashi, Shinsuke Shibata, Shin-Ichiro Karaki, et al. Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice. EBioMedicine. 2024. 106. 105256-105256
Motoyoshi Nagai, Takuma Okawa, Kazuaki Nakata, Daisuke Takahashi, Reina Miyajima, Hiroaki Shiratori, Daisuke Yamanaka, Atsuo Nakamura, Chinatsu Oyama, Shin-Ichiro Takahashi, et al. Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine. Cell reports. 2024. 43. 7. 114490-114490
Hiroaki Shiratori, Kisara M Hattori, Kazuaki Nakata, Takuma Okawa, Seiga Komiyama, Yusuke Kinashi, Yuma Kabumoto, Yuria Kaneko, Motoyoshi Nagai, Tomoko Shindo, et al. Purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations. International immunology. 2024

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MISC (18)：

高橋大輔, 長谷耕二. 【マイクロバイオームと医療応用全身の微生物叢が生理機能と病態をいかに制御するか?】(第2章)マイクロバイオームと生理・病理との関連マイクロバイオームによる生理機能調節腸内細菌による免疫システムの発達. 実験医学. 2024. 42. 17. 2670-2675
高橋大輔, 長谷耕二. 【マルチオミクスデータ駆動時代の疾患研究がん、老化、生活習慣病最新のオミクス統合で挑む標的探索と病態解明】(第3章)各分野におけるマルチオミクス研究マルチオミクスによるIBDにおけるディスバイオーシスの理解. 実験医学. 2023. 41. 15. 2544-2550
高橋大輔. 【病原体や細菌叢と疾患発症のメカニズムを探る】関節リウマチの粘膜起源仮説. 臨床と微生物. 2023. 50. 2. 165-169
込山星河, 高橋大輔, 佐伯愛子, 改正恒康, 長谷耕二. 腸管におけるIL-17産生性γδT細胞の活性化と実験的自己免疫性脳脊髄炎への関与. Neuroimmunology. 2021. 26. 1
室井きさら, 高橋大輔, 長谷耕二. 【食と健康を結ぶメディカルサイエンス生体防御系を亢進し、健康の維持に働く分子機構】(第2章)食による生体防御系の活性化食事因子による腸管の生体防御システムの構築. 実験医学. 2020. 38. 10. 1683-1689

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Lectures and oral presentations (12)：

The diet-microbiota axis consolidates mucosal IgA response by inducing T follicular helper cells in Peyer’s patches
(2025)
Dietary Soy Promotes Mucosal IgA Response via Tfh Cell Induction in Peyer's Patches
(第53回日本免疫学会学術集会 2024)
Induction of Encephalitogenic Phenotypes in γδT17 Cells via M-Ce ll-Mediated Commensal Bacteria Uptake in Peyer’s Patch
(第97回日本生化学会大会 2024)
Gut Immunity and Material Symbiosis: Insights from Microbiota-Induced T Follicular Helper Cells and IgA
(The International Symposium for Young Researchers: Towards a Future of Material Symbiosis 2024)
Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.
(The 46th Annual Meeting of The Japanese Society for Immunology 2017)

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Professional career (1)：

Ph.D. (横浜市立大学)

Work history (3)：

2015/04 - 現在 Keio University Faculty of Pharmacy Division of Biochemistry Senior Assistant Professor
2012/04 - 2015/03 La Jolla Institute for Allergy & Immunology DI1 Postdoctoral Fellow
2008/04 - 2012/03 RIKEN RCAI Research Associate

Awards (6)：

2023/12 - 日本免疫学会 Outstanding Young Immunology Researcher Award
2017/12 - Japanese Society for Immunology Best Presentation Award, The 46th Annual Meeting of the Japanese Society for Immunology
2011/12 - RIKEN RCAI RIKEN RCAI Excellent Paper of the Year 2011
2011/10 - Japanese Society for Immunology. Tadamitsu Kishimoto International Travel Award
2010/12 - Japanese Society for Immunology Melchers’ Travel Award for The 38th Annual Meeting of the Japanese Society for Immunology

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Association Membership(s) (3)：

日本薬学会 , 日本生化学会 , Japanese Society for Immunology

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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