Research field (2)：
Oral medicine (pathology)
, Oral medicine
Research keywords (4)：
Microbiology
, Streptococci
, 菌代謝と病原性
, 口腔微生物学
Research theme for competitive and other funds (15)：
2023 - 2026 Elucidation of the onset mechanism of multiple organ failure in the streptococcal toxic shock syndrome and investigation of new therapeutic methods
2023 - 2025 Elucidation of the mechanism of the organ damage in Streptococcus pyogenes infection
2022 - 2025 Elucidation of the niche expansion mechanism of streptococci and search for new infection control methods
2022 - 2025 Identification of the metabolic mechanism of Streptococcus pyogenes that contributes to its virulence and investigation for methods to control its pathogenicity
2020 - 2023 Structural elucidation of the oral microbiota of healthy children in Thailand and metagenomic wide association analysis
2020 - 2022 Elucidation of the fulminant mechanism of Streptococcus pyogenes infection and search for new vaccine antigens
2019 - 2021 Analysis of Interaction between arginine metabolism and virulence factor on Streptococcus pyogenes
2019 - 2021 Establishing a new infection control method that is less likely to develop bacterial resistance using molecular evolutionary information
2017 - 2020 Analysis of the role of interaction between pneumococci and host's glycosaminoglycans in inflammatory response and establishment of infection
2018 - 2019 Identification of pneumococcal surface proteins involved in the breakthrough of blood-brain barrier and elucidation of the breakthrough mechanism
2016 - 2018 Compositional analysis in oral and gut microbiota
2016 - 2018 Elucidation of the blood-brain barrier breakthrough mechanism by Streptococcus pneumoniae
A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes. 2024
Nitasha D. Menon, Saugat Poudel, Anand V. Sastry, Kevin Rychel, Richard Szubin, Nicholas Dillon, Hannah Tsunemoto, Yujiro Hirose, Bipin G. Nair, Geetha B. Kumar, et al. Independent component analysis reveals 49 independently modulated gene sets within the global transcriptional regulatory architecture of multidrug-resistant Acinetobacter baumannii. mSystems. 2024. 9. 2
Seiko Kubota, Masanobu Nakata, Yujiro Hirose, Masaya Yamaguchi, Bernd Kreikemeyer, Narikazu Uzawa, Tomoko Sumitomo, Shigetada Kawabata. Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator. Microbiology and immunology. 2023. 67. 7. 319-333
Yujiro Hirose, Saugat Poudel, Anand V Sastry, Kevin Rychel, Cameron R Lamoureux, Richard Szubin, Daniel C Zielinski, Hyun Gyu Lim, Nitasha D Menon, Helena Bergsten, et al. Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins. mSystems. 2023. 8. 3. e0024723
