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J-GLOBAL ID：201801011526472039   Update date: Apr. 04, 2025

Inoue Shinichi

イノウエ シンイチ | Inoue Shinichi
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Affiliation and department：
Tohoku University Graduate School of Medicine

About Tohoku University Graduate School of Medicine


Research field  (4)： Metabolism and endocrinology ,  Fetal medicine/Pediatrics ,  Molecular biology ,  Medical biochemistry
Research keywords  (12)： HDAC3 ,  Brown adipose tissue ,  RASopathies ,  UCP1 ,  Nuclear receptor ,  Thermogenesis ,  PGC-1a ,  RAS/MAPK ,  obesity ,  mitochondria ,  energy metabolism ,  C/EBP
Research theme for competitive and other funds  (9)：
  • 2018 - 2020 CFC症候群の心疾患におけるヒストン修飾の役割の解明
  • 2018 - 2020 Crosstalk between mechanism of metabolic abnormalies in congenital disorders and cancer cell metabolism
  • 2017 - 2019 Functional analysis and modeling in RASopathies
  • 2017 - 2019 細胞内シグナル伝達異常による先天性疾患の新しい治療パスウェイ検索と治療法開発
  • 2016 - 2017 Metablic alterarion and growth control in congenital anomaly syndrome
Show all
Papers (28)：
  • Akira Moriya, Shin-Ichi Inoue, Fumihito Saitow, Moe Keitoku, Noato Suzuki, Etsumi Oike, Eriko Urano, Eiko Matsumoto, Hidenori Suzuki, Yoko Aoki, et al. Q241R mutation of Braf causes neurological abnormalities in a mouse model of cardio-facio-cutaneous syndrome, independent of developmental malformations. Human molecular genetics. 2025
  • Shin-Ichi Inoue, Matthew J Emmett, Hee-Woong Lim, Mohit Midha, Hannah J Richter, Isaac J Celwyn, Rashid Mehmood, Maria Chondronikola, Samuel Klein, Amy K Hauck, et al. Short-term cold exposure induces persistent epigenomic memory in brown fat. Cell metabolism. 2024
  • Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, et al. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease. iScience. 2024. 27. 4. 109398-109398
  • Amy K Hauck, Rashid Mehmood, Bryce J Carpenter, Maxwell T Frankfurter, Michael C Tackenberg, Shin-Ichi Inoue, Maria K Krieg, Fathima N Cassim Bawa, Mohit K Midha, Delaine M Zundell, et al. Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis. Nature metabolism. 2024
  • Hannah J Richter, Amy K Hauck, Kirill Batmanov, Shin-Ichi Inoue, Bethany N So, Mindy Kim, Matthew J Emmett, Ronald N Cohen, Mitchell A Lazar. Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 33. e2205276119
ｍore...
MISC (49)：
  • 堅田 有宇, 井上 晋一, 浅尾 敦子, 小林 周平, 照井 仁, 井上 彩, 阿部 太紀, 新堀 哲也, 相場 節也, 石井 直人, et al. Costello症候群モデルマウスにおけるアレルゲンによる皮膚炎の誘発と病態メカニズムの解明. 日本小児科学会雑誌. 2021. 125. 2. 292-292
  • 阿部 太紀, 梅木 郁美, 菅野 新一郎, 井上 晋一, 新堀 哲也, 青木 洋子. がん原遺伝子産物RASの恒常性維持機構の解明. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [P-190]
  • 森谷 晃, 井上 晋一, 青木 洋子, 大西 浩史. 成熟神経細胞特異的RAS/MAPK症候群モデル動物の表現型解析. The Kitakanto Medical Journal. 2020. 70. 3. 296-296
  • 井上 晋一, 高原 真吾, 宮川 幸子[富田], 松浦 勝久, 中嶌 八隅, 新堀 哲也, 松原 洋一, 齋木 佳克, 青木 洋子. RASサブファミリータンパク質RIT1ノックインマウスにおける心疾患病態解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1T02a-01]
  • 井上 晋一, 高原 真吾, 宮川 幸子[富田], 松浦 勝久, 中嶌 八隅, 新堀 哲也, 松原 洋一, 齋木 佳克, 青木 洋子. RASサブファミリータンパク質RIT1ノックインマウスにおける心疾患病態解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1T02a-01]
ｍore...
Patents (1)：
Books (1)：
  • ヌーナン症候群のマネジメント
    メディカルレビュー社 2017 ISBN:9784779220029
Lectures and oral presentations  (34)：
  • Short-term cold exposure induces persistent epigenomic memory in brown fat
    (2024 Department of Medicine Research Day 2024)
  • Short-term mild cold exposure promotes HDAC3-independent adaptive thermogenesis in brown adipose tissue
    (2023 Department of Medicine Research Day 2023)
  • Short-term mild cold exposure promotes HDAC3-independent adaptive thermogenesis in brown adipose tissue
    (Kroc Lecture 2023 2023)
  • Rit1 A57G knock-in mice recapitulate features of Noonan syndrome
    (2019)
  • C-type natriuretic peptide provides a new approach for the treatment of short stature in cardio-facio-cutaneous syndrome
    (2019)
ｍore...
Education (3)：
  • 2008 - 2011 国立大学法人東北大学大学院 薬学研究科
  • 2006 - 2008 National Fisheries University
  • 2002 - 2006 National Fisheries University
Professional career (1)：
  • 薬学博士 (東北大学)
Work history (10)：
  • 2025/04 - 現在 東北大学大学院医学系研究科 遺伝医療学分野 助教
  • 2025/03 - 2025/03 東北大学大学院医学系研究科 遺伝医療学分野 学術研究員
  • 2024/12 - 2025/03 東北大学大学院医学系研究科 遺伝医療学分野 大学院非常勤講師
  • 2021/01 - 2025/02 University of Pennsylvania Perelman School of Medicine Institute for Diabetes, Obesity, and Metabolism Postdoctoral fellow
  • 2020/06 - 2021/02 東北大学大学院医学系研究科 分子代謝生理学分野 助教
Show all
Awards (2)：
  • 2018 - 日本人類遺伝学会 日本人類遺伝学会第63回大会 大会最優秀口演賞
  • 2015 - 4th International RASopathies Symposium, Finalist, Young Investigator Award
Association Membership(s) (2)：
THE JAPANESE BIOCHEMICAL SOCIETY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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