Rchr
J-GLOBAL ID:201801011526472039
Update date: Sep. 13, 2024
Inoue Shinichi
イノウエ シンイチ | Inoue Shinichi
Affiliation and department:
Job title:
Postdoctoral Fellow
Research field (4):
Metabolism and endocrinology
, Fetal medicine/Pediatrics
, Molecular biology
, Medical biochemistry
Research keywords (12):
HDAC3
, Brown adipose tissue
, RASopathies
, UCP1
, Nuclear receptor
, Thermogenesis
, PGC-1a
, RAS/MAPK
, obesity
, mitochondria
, energy metabolism
, C/EBP
Research theme for competitive and other funds (9):
- 2018 - 2020 CFC症候群の心疾患におけるヒストン修飾の役割の解明
- 2018 - 2020 Crosstalk between mechanism of metabolic abnormalies in congenital disorders and cancer cell metabolism
- 2017 - 2019 Functional analysis and modeling in RASopathies
- 2017 - 2019 細胞内シグナル伝達異常による先天性疾患の新しい治療パスウェイ検索と治療法開発
- 2016 - 2017 Metablic alterarion and growth control in congenital anomaly syndrome
- 2015 - 2017 BRAF遺伝子の心臓発生・骨格形成の働き
- 2014 - 2016 RAS/MAPK症候群の原因・病態の解明とその治療戦略
- 2014 - 2015 先天奇形症候群におけるゲノム・エピゲノム連関
- 2013 - 2015 BRAF遺伝子変異をもつCFC症候群発症メカニズムの解明
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Papers (27):
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Shin-Ichi Inoue, Matthew J Emmett, Hee-Woong Lim, Mohit Midha, Hannah J Richter, Isaac J Celwyn, Rashid Mehmood, Maria Chondronikola, Samuel Klein, Amy K Hauck, et al. Short-term cold exposure induces persistent epigenomic memory in brown fat. Cell metabolism. 2024
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Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, et al. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease. iScience. 2024. 27. 4. 109398-109398
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Amy K Hauck, Rashid Mehmood, Bryce J Carpenter, Maxwell T Frankfurter, Michael C Tackenberg, Shin-Ichi Inoue, Maria K Krieg, Fathima N Cassim Bawa, Mohit K Midha, Delaine M Zundell, et al. Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis. Nature metabolism. 2024
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Hannah J Richter, Amy K Hauck, Kirill Batmanov, Shin-Ichi Inoue, Bethany N So, Mindy Kim, Matthew J Emmett, Ronald N Cohen, Mitchell A Lazar. Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 33. e2205276119
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Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, et al. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nature communications. 2021. 12. 1. 7045-7045
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MISC (49):
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堅田 有宇, 井上 晋一, 浅尾 敦子, 小林 周平, 照井 仁, 井上 彩, 阿部 太紀, 新堀 哲也, 相場 節也, 石井 直人, et al. Costello症候群モデルマウスにおけるアレルゲンによる皮膚炎の誘発と病態メカニズムの解明. 日本小児科学会雑誌. 2021. 125. 2. 292-292
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阿部 太紀, 梅木 郁美, 菅野 新一郎, 井上 晋一, 新堀 哲也, 青木 洋子. がん原遺伝子産物RASの恒常性維持機構の解明. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [P-190]
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森谷 晃, 井上 晋一, 青木 洋子, 大西 浩史. 成熟神経細胞特異的RAS/MAPK症候群モデル動物の表現型解析. The Kitakanto Medical Journal. 2020. 70. 3. 296-296
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井上 晋一, 高原 真吾, 宮川 幸子[富田], 松浦 勝久, 中嶌 八隅, 新堀 哲也, 松原 洋一, 齋木 佳克, 青木 洋子. RASサブファミリータンパク質RIT1ノックインマウスにおける心疾患病態解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1T02a-01]
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井上 晋一, 高原 真吾, 宮川 幸子[富田], 松浦 勝久, 中嶌 八隅, 新堀 哲也, 松原 洋一, 齋木 佳克, 青木 洋子. RASサブファミリータンパク質RIT1ノックインマウスにおける心疾患病態解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1T02a-01]
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Patents (1):
Books (1):
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ヌーナン症候群のマネジメント
メディカルレビュー社 2017 ISBN:9784779220029
Lectures and oral presentations (34):
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Short-term cold exposure induces persistent epigenomic memory in brown fat
(2024 Department of Medicine Research Day 2024)
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Short-term mild cold exposure promotes HDAC3-independent adaptive thermogenesis in brown adipose tissue
(2023 Department of Medicine Research Day 2023)
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Short-term mild cold exposure promotes HDAC3-independent adaptive thermogenesis in brown adipose tissue
(Kroc Lecture 2023 2023)
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Rit1 A57G knock-in mice recapitulate features of Noonan syndrome
(2019)
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C-type natriuretic peptide provides a new approach for the treatment of short stature in cardio-facio-cutaneous syndrome
(2019)
more...
Education (3):
- 2008 - 2011 国立大学法人東北大学大学院 薬学研究科
- 2006 - 2008 National Fisheries University
- 2002 - 2006 National Fisheries University
Professional career (1):
Work history (7):
- 2021/01 - 現在 University of Pennsylvania Perelman School of Medicine Institute for Diabetes, Obesity, and Metabolism Postdoctoral fellow
- 2020/06 - 2021/02 国立大学法人東北大学大学院医学系研究科 分子代謝生理学分野 助教
- 2020/03 - 2021/01 University of California, Irvine Department of Biological Chemistry, Center for Epigenetics and Metabolism Postdoctoral fellow
- 2020/05 - 2020/05 国立大学法人東北大学大学院医学系研究科
- 2015/08 - 2020/03 Tohoku University Graduate School of Medicine
- 2011/05 - 2015/07 Tohoku University Graduate School of Medicine
- 2011/04 - 2011/04 Tohoku University Graduate School of Medicine
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Awards (2):
- 2018 - 日本人類遺伝学会 日本人類遺伝学会第63回大会 大会最優秀口演賞
- 2015 - 4th International RASopathies Symposium, Finalist, Young Investigator Award
Association Membership(s) (2):
THE JAPANESE BIOCHEMICAL SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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