Rchr
J-GLOBAL ID：201801011681386661
Update date: Nov. 08, 2024
SHIGETO HIRAYAMA
ヒラヤマ シゲト | SHIGETO HIRAYAMA
Affiliation and department：
Job title：
Assistant Professor
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (4)：
- 2019 - 2022 Development of novel mu-delta opioid receptor agonistic analgesics without analgesic tolerance
- 2016 - 2019 Discovery of novel mu-delta opioid receptor agonistic analgesics with low analgesic tolerance
- 2014 - 2017 Development of selective agonists for the morphine-insensitive opioid mu receptor splice variants
- 2011 - 2013 Investigation of the relationship between opioid kappa receptor subtype and receptor dimerization
Papers (56)：
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Ayaka Watanabe, Shuma Yamada, Haruka Yoshida, Miku Inagaki, Nao Atsumi, Aoba Matsushima, Naoki Takahashi, Naoto Ishibashi, Takumi Ogino, Ryoto Someya, et al. Structure-Activity Relationship Study of CYM51010, an agonist for the μ-δ Opioid Receptor Heterodimer. Chemical and Pharmaceutical Bulletin. 2024. 72. 7. 711-730
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Takashi Iwai, Rei Mishima, Shigeto Hirayama, Honoka Nakajima, Misa Oyama, Shun Watanabe, Hideaki Fujii, Mitsuo Tanabe. SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis. Journal of Clinical Medicine. 2024. 13. 2. 608-608
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Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, et al. Anti-Schistosomal Activity and ADMET Properties of 1,2,5-Oxadiazinane-Containing Compound Synthesized by Visible-Light Photoredox Catalysis. RSC Medicinal Chemistry. 2024
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Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, et al. Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol. Molecules. 2023. 28. 19. 6925-6925
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Kennosuke Itoh, Nanase Ishii, Atsushi Takashino, Aya Hara, Satoshi Kon, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Yoshio Shibagaki, Kenichiro Nagai, et al. Visible-light-Induced synthesis of imidazolidines through formal [3 + 2] cycloaddition of aromatic imines with N,N,N',N'-tetramethyldiaminomethane. Journal of Photochemistry and Photobiology A: Chemistry. 2023. 434. 114239-114239
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MISC (43)：
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平山重人, 上之原由佳, 津村沙織, 東永華, 渡邉友里江, 合田浩明, 長瀬博, 藤井秀明. Synthesis of morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors. 日本薬学会年会要旨集(Web). 2022. 142nd
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Shigeto Hirayama, Hideaki Fujii. Delta Opioid Receptor Inverse Agonists and Their in vivo Pharmacological Effects. Current Topics in Medicinal Chemistry. 2020. 20
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吉田有輝, 吉田有輝, 高橋英希, 高橋英希, 小野晴香, 小野晴香, 目黒由行, 目黒由行, 宮野加奈子, 野中美希, et al. オキシトシンはμおよびκオピオイド受容体に対しpositive allosteric modulator(PAM)として作用する. 日本薬理学雑誌. 2020. 155. Supplement
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山口政広, 山口政広, 山口政広, 宮野加奈子, 根本徹, 原田幸昌, 今出慧海, 野村俊宗, 唐澤佑輔, 唐澤佑輔, et al. Evaluation of activities of nalfurafine derivatives, the κ opioid receptor agonists to develop novel analgesics with fewer side effects. Pain Research. 2020. 35. 4
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渡邊彩花, 高橋直樹, 染谷僚人, 染谷僚人, 松嶋あおば, 石橋尚人, 石橋尚人, 平山重人, 宮野加奈子, 伊藤謙乃介, et al. μ-δオピオイド受容体ヘテロダイマー選択的作用薬創出を志向したCYM51010誘導体合成. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
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Books (1)：
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PHARMACOLOGY Edited by Luca Gallelli
INTECH 2012
Lectures and oral presentations (189)：
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可視光により誘起される芳香族イミンと N,N N',N'-テトラメチルジアミノメタンの形式的 [3+2] 付加環化反応によるイミダゾリジン合成
(第50回複素環討論会 2021)
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δオピオイド受容体インバースアゴニストを志向したN-置換基の検討
(第48回複素環化学討論会 2018)
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7-アザノルボルナンの修飾による立体的な創薬候補化合物ライブラリーを構築する手法の開発
(日本薬学会第138年会 2018)
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異なる置換基を有する1,3,5-トリオキサアザトリキナン誘導体の効率的な合成法の検討
(日本薬学会第138年会 2018)
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可視光応答型レドックス触媒による炭素ラジカル種の共役付加-環化反応
(日本薬学会第138年会 2018)
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