2017 - 2020 Examination of factors disturbed ADCC activity of NK cells to the solid tumor
2016 - 2019 Development of CAR-T immunotherapy targeting molecule X
2014 - 2016 Identification of the HSP70 peptide for the development of cancer immunetherapy
2013 - 2016 The development of new recognition system for cancer stem cell-like cell using RNA aptamer
2012 - 2015 Development of novel immunotherapy targetimg immune checkpoint blockade for recurrent breast cancer
2012 - 2015 Suppressive role of histamine in hepatic colorectal cancer matastasis
2012 - 2015 Development of immune therapy which targets pancreatic cancer stem cells
2011 - 2013 HMGB1 is a new immunological biomarker for prognosis in patients with digestive cancer.
2011 - 2013 Augmentation of ADCC activity according to FcR polymorphisms in patients with gastric cancer who receive monoclonal antibody therapy
2009 - 2011 Cancer Immunotherapy Targeting B7-DC/ B7-H1/ PD-1 interaction May Improve Tumor Microenviroment
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Papers (226):
Eiji Funayama, Masahiro Hosonuma, Kohei Tajima, Junya Isobe, Yuta Baba, Masakazu Murayama, Yoichiro Narikawa, Hitoshi Toyoda, Toshiaki Tsurui, Yuki Maruyama, et al. Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice. Biomedicine & Pharmacotherapy. 2025. 182. 117749-117749
Hitoshi Toyoda, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe, Yuta Baba, Kohei Tajima, Eiji Funayama, Midori Shida, et al. MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells. Scientific reports. 2024. 14. 1. 23401-23401
Yuya Hirasawa, Yutaro Kubota, Emiko Mura, Risako Suzuki, Toshiaki Tsurui, Nana Iriguchi, Tomoyuki Ishiguro, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, et al. Maximum Efficacy of Immune Checkpoint Inhibitors Occurs in Esophageal Cancer Patients With a Low Neutrophil-to-Lymphocyte Ratio and Good Performance Status Prior to Treatment. Anticancer research. 2024. 44. 8. 3397-3407
石黒智之, 高柳大輔, 村英美子, 鶴井敏光, 鈴木梨沙子, 入口菜々, 平澤優弥, 大熊遼太朗, 有泉裕嗣, 久保田祐太郎, et al. Genetic analysis of tumor cells derived from the stress of immune response for understanding of immunotherapy. 日本臨床腫瘍学会学術集会(CD-ROM). 2024. 21st