Harada Hironori

Affiliation and department：

Research field (1)： Hematology and oncology

Research theme for competitive and other funds (26)：

2022 - 2025 血液がん発症におけるミトコンドリア断片化と炎症性シグナル経路活性化のクロストーク
2022 - 2024 免疫担当細胞に着目したがん悪液質病態の発症機序解明と新規治療戦略の構築
2020 - 2023 Molecular diagnosis of myeloid neoplasms using targeted gene panel
2019 - 2023 Comparative Study on the Issues of Nuclear Global Disasters from the Viewpoint of Life, Livelihood and Mind
2019 - 2023 Functional analysis of CCDC26, a noncoding RNA related to myeloid leukemia, and search of a target for treatment of tumor

2019 - 2022 Molecular mechanisms of lower-risk MDS

2016 - 2019 Molecular pathogenesis of familial myelodysplastic syndromes

2015 - 2019 International comparative study of nuclear disasters in Semipalatinsk, Chernoby, Hiroshima/Nagasaki and Fukushima

2015 - 2018 Overexpression of RUNX1 short isoform induced by epigenetic dysregulation in the development of myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

2014 - 2018 Study of the radiation fallout around the former Soviet Union Semipalatinsk nuclear test site - Dosimetry and health effects -

2013 - 2016 Molecular mechanisms of radiation-associated myelodysplastic syndromes (MDS)

2013 - 2015 RUNX1とエピジェネティック制御機構破綻の協調作用によるMDS発症機構の解明

2012 - 2015 Social medical study of late effect of radiation exposure on young persons

2012 - 2015 The function of the novel noncoding RNA related to the growth control of myeloid leukemia cells

2012 - 2015 Molecular mechanisms of myelodysplastic syndromes (MDS) using RUNX1-mutated iPS cells derived from familial MDS patients

2011 - 2014 Research on the radiation exposure among inhabitants near the Semipalatinsk Nuclear Test Site

2011 - 2013 RUNXファミリーの異常による細胞分化制御破綻と新たなMDS発症機構の解明

2010 - 2012 Molecular mechanism of the therapy-related myeloid neoplasms

2009 - 2011 Establishment of new classification in myeloid neoplasms for personalized medicine

2008 - 2010 Human Effects in Inhabitants near the Semipalatinsk Nuclear Test Site

2007 - 2008 AML1 point mutations play a pivotal role in the pathogenesis of MDS/AML

2006 - 2007 Genetic pathway in molecular pathogenesis of myelodysplastic syndrome (MDS) with AML1 point mutations

2005 - 2006 Genetic pathway in molecular pathogenesis of myelodysplastic syndrome

2003 - 2004 Proteomic analysis of AML1/RUNX1 mutant complexes

2002 - 2002 原爆被爆者の骨髄異形成症候群(MDS)

2000 - 2001 赤血球分化における血球特異的RINGフィンガー蛋白、HERF1の分子生物学的役割

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Papers (128)：

Satoshi Kaito, Yuho Najima, Daichi Sadato, Chizuko Hirama, Yuya Kishida, Akihito Nagata, Tatsuya Konishi, Yuta Yamada, Shuhei Kurosawa, Kota Yoshifuji, et al. Azacitidine and gemtuzumab ozogamicin as post-transplant maintenance therapy for high-risk hematologic malignancies. Bone marrow transplantation. 2024
Yasuhiro Kambara, Daichi Sadato, Takashi Toya, Akira Honda, Seiko Kato, Chizuko Hirama, Kyoko Haraguchi, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, et al. Recurrent DDX41 mutation in very late relapse after allogeneic stem cell transplantation. Leukemia. 2024
Kazuya Kurihara, Daichi Sadato, Yuho Najima, Chizuko Hirama, Kyoko Haraguchi, Kana Kato, Kaori Kondo, Yasutaka Sadaga, Chika Kato, Satoshi Sakai, et al. [FLT3-ITD mutation-positive acute myeloid leukemia undergoing clonal transition with PTPN11 mutation at relapse]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2024. 65. 2. 63-68
大内史彦, 新谷直樹, 名島悠峰, 貞任大地, 平間千津子, 加藤可那, 近藤花織, 貞賀泰孝, 加藤千賀, 酒井知史, et al. QuizartinibとDLIで長期寛解を得られた同種移植後の早期再発FLT3変異陽性AML. 日本血液学会学術集会. 2023. 85回. 178-178
貞賀泰孝, 名島悠峰, 加藤可那, 近藤花織, 酒井知史, 加藤千賀, 神原康弘, 奈邊愛美, 手島航, 浅野雄哉, et al. 自家移植後中枢神経再発に対しサリドマイド療法継続し長期生存可能であった多発性骨髄腫の1例. 日本血液学会学術集会. 2023. 85回. 876-876

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MISC (180)：

田辺季佐, 名島悠峰, 井ノ口卓彦, 遠藤麻惠, 西尾優子, 貞任大地, 神原康弘, 熱田雄也, 小沼亮介, 安達弘人, et al. 胚細胞腫瘍の治療後に続発したinv(16)を伴う急性骨髄性白血病発症を契機に診断されたKlinefelter症候群. 臨床血液. 2022. 63. 7. 746-752
酒井知史, 清水啓明, 貞任大地, 平間千津子, 神原康弘, 小沼亮介, 和田敦司, 内堀雄介, 尾内大志, 西島暁彦, et al. TKIに抵抗性を示し、同種移植後早期にCNS再発を認めたCMLの1例. 臨床血液. 2022. 63. 5. 497-497
林嘉宏, 原田浩徳. ミトコンドリア異常による骨髄異形成症候群の発症機序. 血液内科. 2022. 84. 3. 375-380
新谷直樹, 貞任大地, 原田浩徳, 大橋一輝, 原田結花, 土岐典子. フェリチン上昇を伴う骨髄異形成症候群(MDS)の臨床・細胞遺伝学的検討. 日本内科学会雑誌. 2022. 111. 臨増. 183-183
加藤千賀, 名島悠峰, 貞任大地, 貞任大地, 平間千津子, 平間千津子, 酒井知史, 神原康弘, 小沼亮介, 熱田雄也, et al. Venetoclax-based salvage therapy before and after allogeneic stem cell transplantation for AML. 日本造血・免疫細胞療法学会総会プログラム・抄録集. 2022. 44th

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