Rchr
J-GLOBAL ID:201801012321580480
Update date: Nov. 14, 2024
Shirouzu Mikako
シロウズ ミカコ | Shirouzu Mikako
Affiliation and department:
Job title:
チームリーダー
Research field (1):
Structural biochemistry
Research theme for competitive and other funds (9):
- 2022 - 2027 クライオ電顕によるDOCKシグナロソームの動的構造の解明
- 2014 - 2017 Analysis of sensing mechanisms of mineral nutrient through ribosome-RNA complex
- 2013 - 2017 Structural basis of LAMP2 aimed to modulate intracellular trafficking of lysosome
- 2010 - 2015 Structural analysis of HLA class I/II molecules
- 1998 - 1999 RasによるRafの活性化機構の解明
- 1998 - 1998 Ras蛋白質によるターゲット活性化のメカニズム
- 1997 - 1997 Rasタンパク質によるターゲット活性化のメカニズム
- 1996 - 1996 阻害因子の設計をめざした細胞内情報伝達の制御ネットワークの解析
- 1996 - 1996 発癌型Rasに特徴的な細胞内情報伝達機構の解析
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Papers (442):
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Kazutaka Murayama, Miyuki Kato-Murayama, Toshiaki Hosaka, Toshio Kitamura, Shigeyuki Yokoyama, Mikako Shirouzu. Structural basis for the effects of Ser387 phosphorylation of MgcRacGAP on its GTPase-activating activities for CDC42 and RHOA. Journal of structural biology. 2024. 108151-108151
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Kenjyo Miyauchi, Satoshi Kimura, Naho Akiyama, Kazuki Inoue, Kensuke Ishiguro, Thien-Son Vu, Veerasak Srisuknimit, Kenta Koyama, Gosuke Hayashi, Akiko Soma, et al. A tRNA modification with aminovaleramide facilitates AUA decoding in protein synthesis. Nature Chemical Biology. 2024
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Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Seiji Matsuoka, Yuki Maemoto, Noriaki Hashimoto, et al. Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment. Bioorganic & medicinal chemistry letters. 2024. 110. 129856-129856
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Kazutaka Murayama, Toshiaki Hosaka, Mikako Shirouzu, Daisuke Sugimori. Structure of a phosphodiesterase from Streptomyces sanglieri with a novel C-terminal domain. Biochemical and biophysical research communications. 2024. 708. 149784-149784
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Tomomi Kimura-Someya, Kazushige Katsura, Miyuki Kato-Murayama, Toshiaki Hosaka, Tomomi Uchikubo-Kamo, Kentaro Ihara, Kazuharu Hanada, Shin Sato, Kazutaka Murayama, Michiyo Kataoka, et al. Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies. Journal of virology. 2024. 98. 5. e0019724
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MISC (139):
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染谷友美, 染谷友美, 桂一茂, 加藤(村山)美幸, 保坂俊彰, 内窪(加茂)友美, 伊原健太郎, 花田和晴, 村山和隆, 白水美香子, et al. Structural analyses of the norovirus capsid protein revealing binding sites for human monoclonal antibodies. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
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Mutsuko Kukimoto-Niino, Kentaro Ihara, Kazutaka Murayama, Mikako Shirouzu. Structural insights into the small GTPase specificity of the DOCK guanine nucleotide exchange factors. Current Opinion in Structural Biology. 2021. 71. 249-258
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GHANEM Nouran, GHANEM Nouran, MATSUI Takashi, MATSUI Takashi, KANEKO Jun, UCHIKUBO-KAMO Tomomi, SHIROUZU Mikako, HASHIMOTO Tsubasa, OGAWA Tomohisa, OGAWA Tomohisa, et al. Design of staphylococcal two-component pore forming toxin to change pore formation property. 生物物理(Web). 2021. 61. Supplement 1-2
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桑名祐輔, 上崎晃輔, 荒川静花, 白水美香子, 竹本千重, 横川隆志, 堀弘幸. Search for pseudouridine synthase genes for 16S rRNA modification of an extremely-thermophilic eubacterium. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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桑名祐輔, 上崎晃輔, 荒川靜花, 白水美香子, 竹本千重, 横川隆志, 堀弘幸. 高度好熱菌シュードウリジン合成酵素遺伝子二重破壊株の作成方法の開発. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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Patents (25):
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