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J-GLOBAL ID:201801012343093434   Update date: Nov. 20, 2024

Yamanishi Kyosuke

ヤマニシ キョウスケ | Yamanishi Kyosuke
Clips
Affiliation and department:
Research field  (1): Psychiatry
Research keywords  (3): 精神免疫 ,  depression ,  InterLeukin 18
Research theme for competitive and other funds  (11):
  • 2024 - 2027 Exploring immunological and molecular mechanisms involved in obsessive-compulsive disorder with comorbid neurodevelopmental disorders.
  • 2023 - 2026 インフラマソームを中心とした末梢炎症がうつ病を引き起こす機序解明と治療戦略の模索
  • 2023 - 2023 せん妄患者におけるミクログリアを中心とした病態解明
  • 2022 - 2023 The investigation of the neuroinflammatory regulation mechanism focusing on inflammasome
  • 2020 - 2023 The investigation between psychiatric disorders and neuroinflammation focused by interleukin 18
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Papers (50):
  • Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Shivani Patel, Johnny R Malicoat, Nathan James Phuong, Tomoteru Seki, Takaya Ishii, Bun Aoyama, Akiyoshi Shimura, Nipun Gorantla, et al. Discovery of novel protective agents for infection-related delirium through bispectral electroencephalography. Translational psychiatry. 2024. 14. 1. 413-413
  • Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Nipun Gorantla, Akiyoshi Shimura, Tomoteru Seki, Takaya Ishii, Bun Aoyama, Johnny R. Malicoat, Nathan James Phuong, Nicole Jade Dye, et al. LPS-induced delirium-like behavior and microglial activation in mice correlate with bispectral electroencephalography (BSEEG). The journals of gerontology. Series A, Biological sciences and medical sciences. 2024
  • Yoshitaka Nishizawa, Takehiko Yamanashi, Tsuyoshi Nishiguchi, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Akimitsu Tanio, Manabu Yamamoto, Teruhisa Sakamoto, Yoshiyuki Fujiwara, et al. The Genome-wide DNA methylation changes in gastrointestinal surgery patients with and without postoperative delirium: Evidence of immune process in its pathophysiology. Journal of psychiatric research. 2024. 177. 249-255
  • Wen Li, Denan Jin, Shinji Takai, Natsuko Inoue, Kyosuke Yamanishi, Yoshimasa Tanaka, Haruki Okamura. IL-18 primes T cells with an antigen-inexperienced memory phenotype for proliferation and differentiation into effector cells through Notch signaling. Journal of Leukocyte Biology. 2024
  • Akiyoshi Shimura, Tomoteru Seki, Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Takaya Ishii, Bun Aoyama, Hieu Dinh Nguyen, Nipun Gorantla, Takeshi Inoue, Gen Shinozaki. A web-based delirium detection application using bispectral electroencephalography (BSEEG). General hospital psychiatry. 2024
more...
MISC (59):
  • 櫻井 正彦, 山西 恭輔, 細井 幸彦, 荻野 俊, 向井 馨一郎. 神経発達症併存の有無による強迫症患者の遺伝子を含む免疫学的機序に関する比較検討. 精神神経学雑誌. 2024. 2024特別号. S535-S535
  • 山西 恭輔. インフラマソームを中心とした脳内炎症の制御機構解明. 上原記念生命科学財団研究報告集. 2023. 37. 1-6
  • 山西 恭輔. インフラマソームを中心とした末梢炎症がうつ病を引き起こす機序解明と新規治療戦略の模索. 先進医薬研究振興財団研究成果報告集. 2023. 2022年度. 72-74
  • 李 文, 高井 真司, 金 徳男, 山西 恭輔, 山西 博道, 岡村 春樹. IL-18の抗腫瘍作用 effector CD8 T cellの代謝/増殖に及ぼす影響(IL-18 enhances anti-tumor effect of memory CD8+ T cells by augmenting metabolic activity and function). 日本癌学会総会記事. 2022. 81回. P-1155
  • 山西 恭輔, 土江 伸誉, 向井 馨一郎, 橋本 卓也, 蒲池 直美, 秦 正樹, 渡辺 優子, 山西 千晶, 岡村 春樹, 松永 寿人. インターロイキン18の急性ストレス下での脳内炎症と精神症状への影響について. 精神神経学雑誌. 2022. 124. 4付録. S-642
more...
Patents (1):
Lectures and oral presentations  (6):
  • Epigenetic analysis of depression-like behavior in interleukin-18-deficient mice
    (24th World Congress on Advances in Oncology and 24 th International Symposium on Molecular Medicine 2019)
  • Histone acetylation and neurogenesis are associated with hippocampal abnormalities in interleukin-18-deficient mice
    (23rd World Congress on Advances in Oncology and 22nd International Symposium on Molecular Medicine 2018)
  • An investigation regarding the causal effect of interleukin-18-deficient condition on hippocampal abnormalities and depression-like behavioral changes
    (WFSBP 2018 KOBE 2018)
  • Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
    (WPA XVII World Congress of Psychiatry 2017)
  • Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior
    (21th World Congress on Advances in Oncology and 19th International Symposium on Molecular Medicine 2016)
more...
Professional career (1):
  • 博士(医学) (兵庫医科大学院)
Awards (3):
  • 2022/07 - JSNP Excellent Presentation Award for CINP 2022
  • 2018/06 - 114th Annual Meeting of the Japanese Society of Psychiatry and Neurology. Best Presentation Award
  • 2017/06 - 113th Annual Meeting of the Japanese Society of Psychiatry and Neurology Best Presentation Award
Association Membership(s) (6):
Japanese Society of Biological Psychiatry(JSBP) ,  The Japanese Psychogeriatric Society ,  The Japanese Society of Neuropsychopharmacology ,  Japan Society for Dementia Research ,  Japanese Society of General Hospital Psychiatry ,  The Japanese Society of Psychiatry and Neurology
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