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J-GLOBAL ID：201801012513588581 Update date: Feb. 23, 2025

Miyai Tomohiro

ミヤイトモヒロ | Miyai Tomohiro

Affiliation and department：
Job title： Research Scientist
Other affiliations (2)：

RIKEN TRIP Headquarters RIKEN Program for Drug Discovery and Medical Technology Platforms (DMP) Theme Leader
Keio University School of Medicine Department of Dermatology Collaborative Researcher

Research field (4)： Cell biology , Molecular biology , Physiology , Immunology

Research keywords (5)： drug discovery , inflammation , pruritus , Allergy , Atopic dermatitis

Research theme for competitive and other funds (4)：

2022 - 2025 Development of novel molecular-targeting drugs for atopic dermatitis applying macrocyclic peptides
2022 - 2025 Mechanistic Investigation of atopic dermatitis associated with abnormality in endocrine and metabolic systems
2020 - 2022 Dysregulation of metabolic and endocrine systems that triggers the onset of atopic dermatitis
2018 - 2020 Elucidation of mechanism for triggering an onset of atopic dermatitis

Papers (15)：

Ryo Hirase, Tomoyuki Fujita, Tomohiro Miyai, Hiroshi Kawasaki, Haruhiko Koseki. Pharmacological Impacts of Mucopolysacccharide Polysulfates in the Epidermis Involves Inhibition of Amphiregulin-Mediated Signals in Keratinocytes. Experimental Dermatology. 2024. 33. 10
Jonathan Moody, Tsukasa Kouno, Miki Kojima, Ikuko Koya, Julio Leon, Akari Suzuki, Akira Hasegawa, Taishin Akiyama, Nobuko Akiyama, Masayuki Amagai, et al. A single-cell atlas of transcribedcis-regulatory elements in the human genome. bioRxiv. 2023
Aiko Sekita, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Kiyoshi Yashiro, Keiji Tanese, Susumu Toshima, Koichi Ashizaki, Tomohiro Miyai, Junshi Yazaki, Atsuo Kobayashi, et al. Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis. Nature Communications. 2023. 14. 1
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, et al. PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment. Nature Communications. 2022. 13. 1. 7159-7159
Tomohiro Miyai, Junichiro Takano, Takaho A. Endo, Eiryo Kawakami, Yasutoshi Agata, Yasutaka Motomura, Masato Kubo, Yukie Kashima, Yutaka Suzuki, Hiroshi Kawamoto, et al. Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes and Development. 2018. 32. 2. 112-126

MISC (6)：

T. Miyai, H. Kawasaki, H. Matsunaga, M. Hosokawa, A. Sekita, H. Takeyama, M. Amagai, H. Koseki. 162 Application of microdissection-based spatial transcriptomics for mechanistic and biomarker investigations in dermatology. Journal of Investigative Dermatology. 2021. 141. 5. S29-S29
T Miyai, H Kawasaki, M Hosokawa, H Matsunaga, R Satoh, A Sekita, H Takeyama, M Amagai, H Koseki. Micro-regional transcriptome reveals local dermal-epidermal intercorrelation in atopic dermatitis. Journal of Investigative Dermatology. 2020. 140. 7. S109
Tomohiro Miyai, Tomokatsu Ikawa. Stepwise transcriptional regulation that drives the commitment of multipotent progenitors into B cells. Clinical Immunology & Allergology. 2018. 70. 5. 503-513
ISHIGAME Harumichi, TAKAHASHI Sonoko, TAKAHASHI Sonoko, TAKAHASHI Sonoko, TAKAHASHI Noriko, ANDO Yoshikazu, IKENO Takashi, IKENO Takashi, MIYAI Tomohiro, IKAWA Tomokatsu, et al. Critical roles for Rho-associated coiled-coil containing protein kinases in B cell development, maintenance, and germinal center responses. 日本免疫学会総会・学術集会記録(CD-ROM). 2018. 47
T. Ikawa, T. Miyai, H. Kawamoto. Transcriptional networks that establish B cell identity. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 6-6

Lectures and oral presentations (13)：

Preparation and evaluation of proteins involved in the IL-31 pathway for the treatment of Atopic dermatitis
Microdissection-based spatial transcriptomics unraveled orchestrated epidermal-dermal interactions in atopic dermatitis
(2022 ESDR Annual Meeting 2022)
Application of microdissection-based spatial transcriptomics for mechanistic and biomarker investigations in dermatology
(2021 SID Virtual Meeting 2021)
FGF23 is a novel endocrine regulator for the pathogenesis of atopic dermatitis
(The 48th Annual Meeting of The Japanese Society for Immunology 2019)
Transcriptional network for proper fate devision into B cell lineage.
(The 44th Annual Conference of Japanese Society of Immunology 2015)

Education (2)：

Professional career (1)：

Work history (8)：

2021/04 - 現在 RIKEN IMS Laboratory for Developmental Genetics Research Scientist
2020/01 - 現在 Keio University School of Medicine Department of Dermatology Collaborative Researcher
2019/03 - 現在 RIKEN Program for Drug Discovery and Medical Technology Platforms Theme Leader for Development of Atopic Dermatitis Therapeutic Agents
2020/04 - 2021/03 RIKEN Lab for Developmental Genetics, Center for Integrative Medical Sciences / Immunology Data Integration Unit, Medical Sciences Innovation Hub Program Postdoctoral Researcher
2017/08 - 2020/03 RIKEN Lab for Developmental Genetics (Center for Integrative Medical Sciences) / Disease Biology Group (Medical Sciences Innovation Hub Program) Postdoctoral Researcher

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Awards (6)：

2020/06 - 10x Genomics Visium Clinical Translational Research Network
2020/02 - Biolegend / Tomy Digital Biology LEGEND Travel Award 2020
2018/03 - RIKEN Research Incentive Award
2015 - Japan Society for Immunology Tadamitsu Kishimoto International Travel Award
2014/06 - トランスポーター研究会優秀発表賞

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Association Membership(s) (2)：

THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE JAPANESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY

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