Shimono Kazumi

シモノカズミ | Shimono Kazumi

Affiliation and department：
Job title： Professor

Research field (2)： Biophysics , Pharmaceuticals - analytical and physicochemistry

Research keywords (3)：分子認識 , 熱力学 , 薬物トランスポーター

Research theme for competitive and other funds (3)：

2019 - 2022 Basic research on thermodynamics-based drug design of multi drug efflux transporter inhibitors
2011 - 2013 Thermodynamics-based mechanism for the regulation of substrate binding affinity of proton coupled drug transporters
2007 - 2010 Development of Expression System for Photoreceptor Using Cell-free Protein Synthesis and Application of Its system for Their Functional Analysis

Papers (89)：

Akiko Omori, Shotaro Sasaki, Takashi Kikukawa, Kazumi Shimono, Seiji Miyauchi. Elucidation of a Thermodynamical Feature Attributed to Substrate Binding to the Prokaryotic H+/Oligopeptide Cotransporter YdgR with Calorimetric Analysis: The Substrate Binding Driven by the Change in Entropy Implies the Release of Bound Water Molecules from the Binding Pocket. Biochemistry. 2023. 62. 11. 1608-1618
Omori, A., Fujisawa, Y., Sasaki, S., Shimono, K., Kikukawa, T., et al. Protonation state of a histidine residue in human oligopeptide transporter 1 (hPEPT1) regulates hPEPT1-mediated efflux activity. Biological and Pharmaceutical Bulletin. 2021. 44. 59. 678-685
Miyamoto, S.*., Shimono, K. Molecular Modeling to Estimate the Diffusion Coefficients of Drugs and Other Small Molecules. Molecules. 2020. 25. 22. 5340
Sugio K, Inoda D, Masuda M, Azumaya I, Sasaki S, Shimono K, Ganapathy V, Miyauchi S. Transport of 2,4-dichloro phenoxyacetic acid by human Na⁺-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8). Drug Metabolism and Pharmacokinetics. 2019. 34. 1. 95-103
Riho Takayama, Akimasa Kaneko, Takashi Okitsu, Satoshi P. Tsunoda, Kazumi Shimono, Misao Mizuno, Keiichi Kojima, Takashi Tsukamoto, Hideki Kandori, Yasuhisa Mizutani, et al. Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative. Journal of Physical Chemistry Letters. 2018. 9. 11. 2857-2862

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MISC (23)：

Shimono, K.* and Dencher, N.A. Recent advances in signaling and activation mechanism in microbial rhodopsins: Report for the session 6 at the 19th International Conference on Retinal Proteins. Biophysics and Physicobiology. 2023. e201009
Miyamoto, S.* and Shimono, K. Estimation of the Diffusion Coefficients of Small Molecules by Diffusion Measurements with Agar-gel and Theoretical Molecular Modeling. Chem-Bio Informatics Journal. 2022. 22. 13-20
下野和実白水美香子,横山茂之*. 無細胞タンパク質合成系を活用した膜タンパク質合成方法. 実験医学. 2010. 28. 1775-1780
下野和実白水美香子,横山茂之*. 無細胞タンパク質合成系を活用した膜タンパク質合成法の開発. バイオインダストリー. 2010. 27. 55-63
Shimono K., Sudo Y., Iwamoto M., Kamo N. 1P259 Amino acid residues regulating the color among archaeal rhodopsins. Seibutsu Butsuri. 2004. 44. S94

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Patents (2)：

Books (3)：

Lectures and oral presentations (7)：

大腸菌多剤排出トランスポーターEmrE の基質結合における水分子の役割
(第41回生体膜と薬物の相互作用シンポジウム 2019)
大腸菌多剤排出トランスポーターEmrEにおける基質結合駆動エネルギーのpH依存的転換メカニズム
(第14回トランスポーター研究会年会 2019)
Thermodynamics of multidrug recognition in multidrug transporter, EmrE
(The 56th Annual Meeting of the Biophysical Society of Japan 2018)
プロトン共役多剤排出トランスポーターの脱水和エントロピーによる基質親和性の制御
(第13回トランスポーター研究会年会 2018)
多剤排出トランスポーターEmrEの基質結合におけるタンパク質内部水分子の役割
(第34回日本薬学会九州支部大会 2017)

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Education (4)：

1999 - 2002 Hokkaido University Graduate School, Division of Pharmaceutical Sciences
1997 - 1999 Hokkaido University Graduate School, Division of Pharmaceutical Sciences
1997 - 1999 Hokkaido University Graduate School, Division of Pharmaceutical Sciences
1993 - 1997 Hokkaido University Faculty of Pharmaceutical Science

Professional career (1)：

Work history (9)：

2017/04 - 現在 /(DC)Division of Pharmaceutical Sciences
2017/04 - 現在 SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2012/12 - 2017/03 Toho University Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences Associate Professor
2008/04 - 2012/11 Matsuyama University Department of Pharmaceutics, Faculty of Pharmaceutical Sciences Assistant Professor
2005/02 - 2008/03 RIKEN SSBC Researher Postdoc

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Association Membership(s) (3)：

Japan Transporter Research Association , The Pharmaceutical Society of Japan , The Biophysical Society of Japan

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