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J-GLOBAL ID：201801012721435799 Update date: Mar. 12, 2025

Hayashi Takeharu

ハヤシタケハル | Hayashi Takeharu

Affiliation and department：
Job title： Professor

Research field (7)： Cardiology , Internal medicine - General , Medical biochemistry , Pharmacology , Clinical pharmacy , Physiology , Anatomy

Research keywords (3)： Genome-based drug discovery , disease-causing gene , Cardiomyopathy

Research theme for competitive and other funds (8)：

2021 - 2026 Elucidation of pathogenesis in high-risk group hypertrophy cardiomyopathy
2024 - 2025 Towards the provision of novel therapies for cardiomyopathy
2023 - 2024 肥大型心筋症の新規治療法の開発
2017 - 2019 心筋症の遺伝的病因に基づく新規予防、治療法の開発
2017 - 2019 新規原因遺伝子を基盤とした心筋症の治療法の開発

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Papers (51)：

Natsuko Inagaki, Yasuyoshi Takei, Tsuguhisa Hatano, Yasuyuki Takada, Yoshinao Yazaki, Hisanori Kosuge, Masatake Kobayashi, Shinji Suzuki, Tomohiro Umezu, Masahiko Kuroda, et al. Clinical characteristics of female Fabry disease patients with hypertrophic cardiomyopathy with mid-ventricular obstruction. Molecular genetics and metabolism reports. 2025. 42. 101196-101196
Natsuko Inagaki, Tomoya Okano, Masatake Kobayashi, Masatsune Fujii, Yoshinao Yazaki, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Takeharu Hayashi, Masahiko Kuroda, et al. Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant. Human Genome Variation. 2024
Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura. Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy. Human Genome Variation. 2022. 9. 1. 6-6
Kayoko Hirayama-Yamada, Natsuko Inagaki, Takeharu Hayashi, Akinori Kimura. A Novel Titin Truncation Variant Linked to Familial Dilated Cardiomyopathy Found in a Japanese Family and Its Functional Analysis in Genome-Edited Model Cells. International Heart Journal. 2021. 62. 2. 359-366
Takeharu Hayashi. Hypertrophic Cardiomyopathy: Diverse Pathophysiology Revealed by Genetic Research, Toward Future Therapy. The Keio journal of medicine. 2020

MISC (19)：

林丈晴, 稲垣夏子, 木村彰方. 心臓突然死予防を要する肥大型心筋症の病因解明に向けて. 日本心臓病学会学術集会(Web). 2023. 71st
稲垣夏子, 林丈晴, 武井康悦, 桐林和代, 木村彰方. RBM20遺伝子は新規の肥大型心筋症の原因遺伝子か?. 日本人類遺伝学会大会プログラム・抄録集. 2021. 66th (CD-ROM)
稲垣夏子, 林丈晴, 武井康悦, 若井未央, 森島靖行, 沼部博直, 近森大志郎, 木村彰方. GLA変異とMYBPC3変異を有する心ファブリー病の1例. 日本人類遺伝学会大会プログラム・抄録集. 2017. 62nd
稲垣夏子, 林丈晴, 武井康悦, 近森大志郎, 山科章, 木村彰方. 心室中部閉塞型肥大型心筋症の病因変異探索. 日本人類遺伝学会大会プログラム・抄録集. 2015. 60th
Hirokazu Enomoto, Shinji Makino, Nishant Mittel, Akinori Kimura, Takuro Arimura, Takeharu Hayashi, Takayuki Inomata, Keiichi Fukuda. Up Regulation of Autophagy in Hsp60 Mutant Heart is an Adaptive Response to Increased Oxidative Stress and Causes Cardiomyopathy. CIRCULATION. 2014. 130

Education (2)：

- 2004 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
- 1994 Hiroshima University Faculty of Medicine

Professional career (1)：

Work history (10)：

2023/04 - 現在 Tokai University School of Medicine Faculty of Medicine Professore
2020/04 - 現在 Tokyo Dental College Visiting Professor
2019/04 - 2022/03 Tokai University School of Medicine, Faculty of Medicine Professor
2018/06 - 2019/03 Keio University School of Medicine School of Medicine Adjunct Associated Professor
2013/05 - 2018/04 Tokyo Medical and Dental University Medical Research Institute Associated Professor

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