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J-GLOBAL ID：201801013844221315 Update date: Apr. 10, 2025

Tsubota Akihito

ツボタアキヒト | Tsubota Akihito

Affiliation and department：
Job title： Professor

Research field (1)： Gastroenterology

Research theme for competitive and other funds (14)：

2024 - 2027 新規肝がん本態機構に基づく早期肝がんに対する高性能診断法の臨床開発
2022 - 2025 肝癌特異的な細胞外分泌蛋白を用いた新規早期診断法確立とその実用化に向けた検証研究
2022 - 2025 B型肝炎ウイルス持続感染実験モデルを用いた病態解明及び新しい治療法の開発に資する研究
2022 - 2025 Intrahepatocellular organelle abnormalities and occult HCV that remain long-term after HCV elimination
2019 - 2023 B型肝炎ウイルスのステルス性による慢性感染成立の機序解明と阻止分子標的の創薬

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Papers (379)：

Kaoru Ueda, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Ayano Matsumoto, Hayato Mikuni, Masashi Ishikawa, et al. Serum PKCδ is a useful biomarker to distinguish hepatocellular carcinoma from other gastrointestinal cancers. Biochemical and Biophysical Research Communications. 2025. 751. 151431-151431
Kaori Koyano, Masanori Atsukawa, Akihito Tsubota, Chisa Kondo, Takao Miwa, Tadashi Namisaki, Atsushi Hiraoka, Hidenori Toyoda, Toshifumi Tada, Yuji Kobayashi, et al. Association Between Laboratory Values and Covert Hepatic Encephalopathy in Patients with Liver Cirrhosis: A Multicenter, Retrospective Study. Journal of Clinical Medicine. 2025
Takashi Niwa, Chisato Saeki, Mitsuru Saito, Tsunekazu Oikawa, Hiroshi Kamioka, Tomoya Kanai, Kaoru Ueda, Masanori Nakano, Yuichi Torisu, Masayuki Saruta, et al. Impact of frailty and prevalent fractures on the long-term prognosis of patients with cirrhosis: a retrospective study. Scientific Reports. 2025. 15. 1
Yohei Sato, Misa Yura, Alana Chandler, Yamato Hanawa, Akihito Tsubota. Integrated transcriptomic, metabolomic, and lipidomic analyses reveal a unique lipid profile of regulatory T cells upon activation. 2024
Yohei Sato, Yamato Hanawa, Akihito Tsubota. CRISPR/Cas9-mediated RELA and RELC knockout in human regulatory T cells abrogates FOXP3 expression and suppressive function. Clinical Immunology Communications. 2024. 6. 15-25

MISC (116)：

青柳東代, 飯島尋子, 松田麻未, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 杉山真也, 坪田昭人, 島田紀朋, et al. Correlation between hepatocellular organelles, gene expression abnormalities and carcinogenesis following elimination of hepatitis C virus. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
及川恒一, 山田幸司, 坪田昭人, 佐伯千里, 上田薫, 神岡洋, 春木孝一郎, 池上徹, 吉田清嗣, 猿田雅之. 早期診断に有用な肝細胞癌特異的バイオマーカー血清PKCδ. 肝細胞研究会プログラム・抄録集. 2023. 30th
青柳東代, 飯島尋子, 松田麻未, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 杉山真也, 坪田昭人, 島田紀朋, et al. C型肝炎ウイルス除去後のオルガネラ異常. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2022. 69th
糸川典夫, 厚川正則, 島田紀朋, 安部宏, 三上繁, 淺野徹, 平岡淳, 中牟田誠, 魚嶋晴紀, 小川力, et al. TAF療法におけるHBs抗原低下作用に関する検討. 肝臓. 2019. 60. Supplement 2
中野真範, 及川恒一, 木下勇次, 木下千夏, 富田陽一, 高野啓子, 石田仁也, 高倉一樹, 鳥巣勇一, 石川智久, et al. 当院におけるHIV/HCV重複感染例に対するDAA治療. 日本消化器病学会雑誌(Web). 2019. 116

Books (11)：

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