Shimi Takeshi

シミタケシ | Shimi Takeshi

Affiliation and department：
Job title： Specially Appointed Associate Professor

Research field (1)： Cell biology

Research keywords (3)： Nuclear structure and functions , Fluorescence Microscopy , Cell Biology

Research theme for competitive and other funds (5)：

2024 - 2027 核ラミナとヘテロクロマチンの構造が相互依存する分子メカニズムの解明
2021 - 2025 細胞核形成における分子機構についての研究
2020 - 2025 細胞シート工学を用いたラミノパチー疾患モデル構築と核ラミナ修復機構の解明
2020 - 2023 核ラミナが核膜孔複合体の構築を制御する分子メカニズムの解明
2019 - 2021 Structural study of the association between the nuclear lamina and nuclear pore complexes

Papers (47)：

Yohei Kono, Takeshi Shimi. Crosstalk between mitotic reassembly and repair of the nuclear envelope. Nucleus. 2024
Takehiko Ichikawa, Yohei Kono, Makiko Kudo, Takeshi Shimi, Naoyuki Miyashita, Tomohiro Maesaka, Kojiro Ishibashi, Takeshi Yoshida, Kundan Sivashanmugan, Rikinari Hanayama, et al. Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells. 2024
Yohei Kono, Chan-Gi Pack, Takehiko Ichikawa, Arata Komatsubara, Stephen Adam, Keisuke Miyazawa, Loïc Rolas, Sussan Nourshargh, Ohad Medalia, Robert D Goldman, et al. Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture. PNAS Nexus. 2024
Yohei Kono, Takeshi Shimi. Defective nuclear envelope repair in laminopathies. Journal of Japanese Biochemical Society. 2024. 96. 1. 101-105
Yohei Kono, Chan-Gi Pack, Takehiko Ichikawa, Arata Komatsubara, Stephen A. Adam, Keisuke Miyazawa, Loïc Rolas, Sussan Nourshargh, Ohad Medalia, Robert D. Goldman, et al. Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome. bioRxiv. 2023

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MISC (64)：

作本遥香, 河野洋平, 志見剛, 西村達也, 谷口剛史, 前田勝浩. ポリ(ジフェニルアセチレン)誘導体を用いる水溶性光レドックス触媒の開発. 令和6年度高分子学会北陸支部若手研究発表会. 2024. P9
Takehiko Ichikawa, Makiko Kudo, Yohei Kono, Takeshi Shimi, Takeshi Fukuma. Nanoendoscopy-AFM measurement of the effect of epithelial-mesenchymal transition on nuclear membrane elasticity in the living cell. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th. 3MS-04-01
川瀬雅貴, 河野洋平, 市川壮彦, 木村宏, 福間剛士, 眞貝洋一, 志見剛. 細胞核の力学的特性はヘテロクロマチン構造によって強化される. 日本遺伝学会第96回大会. 2024. O3-4
Yohei Kono, Tatsuya Niwa, Yixian Zheng, Stephen A. Adam, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi. Establishment and analysis of immortalized mouse embryonic fibroblasts lacking all lamins. 日本細胞生物学会大会講演要旨集 76回. 2024. 3P20
Takehiko Ichikawa, Kundan Sivashanmugan, Takeshi Shimi, Kojiro Ishibashi, Takeshi Yoshida, Makiko Kudo, Eishu Hirata, Rikinari Hanayama, Hiroshi Kimura, Takeshi Fukuma. Nanoendoscopy-AFM measurement of nuclear stiffness in living different metastatic cancer cells. 21st International Union of Pure and Applied Biophysics and 62nd Biophysics Society of Japan (IUPAB-BSJ 2024). 2024. 25P-240

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Patents (4)：

Lectures and oral presentations (7)：

New insights into the structure of the nuclear lamina revealed by nanoscale resolution microscopy
(Cold Spring Harbor Meeting Nuclear Organization and Function 2014)
Three-dimensional structure and organization of the nuclear lamina revealed by nanoscale resolution microscopy
(The 4D Nucleome 2014)
Loss of nuclear lamin B1 is required for chromatin remodeling during cellular senescence
(Molecular Biology Society of Japan Annual Meeting 2013)
The nuclear lamin networks: defining the chromatin landscape
(Symposium: chromatin structure dynamics and functions 2013)
The roles of nuclear lamin B1 in poliferation, longevity and senescence
(American Society for Cell Biology 51st Annual Meeting 2011)

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Professional career (1)：

Work history (8)：

2023/07 - 現在 Kanazawa University Nano Life Science Institute, World Premier International Research Center Initiative (WPI) Specially Appointed Associate Professor
2018/04 - 2023/05 Tokyo Institute of Technology Cell Biology Center, Institute of Innovative Research Specially Appointed Associate Professor
2017/08 - 2019/03 Northwestern University, Feinberg School of Medicine Department of Cell and Molecular Biology Research Assistant Professor
2016/05 - 2017/07 Northwestern University, Feinberg School of Medicine Department of Biochemistry and Molecular Genetics Research Assistant Professor
2015/06 - 2016/04 University of Chicago Department of Human Genetics Staff Scientist

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