Takanori Kanai

2016 - 2019 Investigation of the mechanisms for inhibitory effects on colonic inflammation and cancer of indigo naturalis including indole compounds

2015 - 2018 Elucidation of the pathology and treatment of refractory small intestinal ulcer disease using genetically engineered mouse and PG mass spectrometry

2015 - 2018 Development of therapeutic strategy for identification of new markers for ulcerative colitis associated colorectal cancers.

2015 - 2018 To identify the mechanism of inflammatory bowel disease by using human microbe mono-associated mouse

2015 - 2018 難治性クローン病に対する神経難病治療薬OCH-NCNPの有用性および安全性を検証する医師主導治験

2015 - 2017 Development of new vaccine therapy to promote the symbiotic bacteria in gut.

2013 - 2016 The interaction between the intestinal microbiota and hepatic macrophages in the pathogenesis of liver fibrosis

2012 - 2015 Identification of Symbiosis pattern decision factors and its reeducation program

2012 - 2015 Molecular characterization of Colitis Associated Cancer

2012 - 2014 Challenge to the cell therapy by reprogramming colitogenic memory T cells

2011 - 2013 Research of Inflammatory Bowel Disease Based on Clinical Immunology and Endoscopy

2011 - 2013 The microbiota in inflammatory bowel disease with resistance to anti-TNF therapy.

2010 - 2012 Challenging to the real-time in vivo diagnosis for inflammatory bowel disease by using super-magnifying endoscope.

2010 - 2012 Pathogenesis of autoimmune hepatic injury through the migration of immunocompetent cells into the liver

2010 - 2011 自己類似腸内細菌フローラに対する免疫寛容とその破綻による炎症性腸疾患発症解明

2009 - 2011 Permanent cure strategy of inflammatory bowel diseases by inducing immunological reset

2009 - 2011 Investigation of intestinal macrophage in contribution to gut immune homeostasis and its disruption in Crohn's disease

2008 - 2009 自己類似腸内細菌に対する末梢性免疫寛容の生体ライフスパンとその破綻

2007 - 2008 Immunosenescent colitogenic CD4^+ T cells convert to regulatory cells and suppress colitis

2007 - 2008 The development of regulatory T cell therapy using leukocyte apheresis for inflammatory bowel disease

2007 - 2008 Circulating colitogenic CD4+ memory T cells between bone marrow and intestine may be targets for the treatment of inflammatory bowel diseases

2006 - 2007 ミラクルビーズによる炎症性腸疾患責任抗原の同定と特異的免疫療法の開発

2005 - 2006 The development of 2nd generated leukocytapheresis to remove phathological immune cells in inflammatory bowel diseases

2005 - 2006 The establishment of bacteria antigen-specific T cell transgenic mice develop spontaneous chronic colitis, and the development of inhibitory probiotics for the treatment of inflammatory bowel diseases

2005 - 2006 自己免疫疾患緩解増悪における免疫記憶細胞の役割とその免疫統御療法の開発

2005 - 2005 生体内で利用可能な超高周波低温プラズマを薬物担体として用いた内視鏡デバイスの開発

2003 - 2004 Establishment of transgenic mice that recognize bacteria specific antigen and develop spontaneous colitis under specific pathogen free condition.

2003 - 2004 骨髄-腸上皮相互作用による腸管上皮幹細胞システム制御機構の解析

2002 - 2003 Elucidation of the regulatory mechanisms for mucosal immune response by mucosal IL-7/IL-7 receptor system

2002 - 2002 消化管粘膜免疫の特殊性を応用した腸管免疫機構の統御療法

2001 - 2002 Establishment of a novel therapy of Inflammatory bowel disease by inducible oral tolerance

2001 - 2002 Elucidation of the mechanism for regurating mucosal immune response and application for the treatment of chronic colitis and food allergy.

2001 - 2001 単クローン抗体を封入した病変部指向性磁性体による大腸疾患診断システムの開発

1997 - 1999 経口ワクチン開発のための腸管内HIV特異的細胞傷害性T細胞に関する基礎的研究