Suzuki Nobuharu

スズキノブハル | Suzuki Nobuharu

Affiliation and department：
Job title： Associate Professor

Research field (1)： Molecular biology

Research theme for competitive and other funds (15)：

2020 - 2024 Morphological and Biochemical Profiling of the Degeneration of Small Caliber Axons Using a Murine Model for Myelin-related Diseases
2020 - 2023 Study on the mechanism of myelination of small diameter axons in the CNS and its potential application for related diseases
2020 - 2023 髄鞘関連疾患モデルマウスを用いた小径軸索変性の形態学的・生化学的プロファイリング
2019 - 2022 The mechanism of CNS myelination through axon diameters and oligodendrocyte subtypes
2020 - 2021 Elucidation of the mechanism of size-dependent axon degeneration with myelination defect and identification of the novel marker for the degeneration

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Papers (37)：

Chikako Hayashi, Nobuharu Suzuki, Riko Takahashi, Chihiro Akazawa. Development of type I/II oligodendrocytes regulated by teneurin-4 in the murine spinal cord. Sci Rep. 2020. 10. 1. 8611-8611
Chikako Hayashi, Nobuharu Suzuki, Yo Mabuchi, Naomi Kikura, Yukina Hosoda, Susana de Vega, Chihiro Akazawa. The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation. Biochem Biophys Res Commun. 2020. 523. 1. 171-176
Nobuharu Suzuki, Mai Hyodo, Chikako Hayashi, Yo Mabuchi, Kaori Sekimoto, Chinami Onchi, Kiyotoshi Sekiguchi, Chihiro Akazawa. Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells. Sci Rep. 2019. 9. 1. 19882-19882
Yusuke Ogata, Yo Mabuchi, Kosuke Shinoda, Yuta Horiike, Mitsuru Mizuno, Koji Otabe, Eriko Grace Suto, Nobuharu Suzuki, Ichiro Sekiya, Chihiro Akazawa. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage. Regen Ther. 2018. 8. 20-28
Kana Ishii, Hidetoshi Sakurai, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Kiyotoshi Sekiguchi, Chihiro Akazawa. Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro. Stem Cell Reports. 2018. 10. 2. 568-582

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MISC (7)：

Momona Yamada, Miho Iwase, Binri Sasaki, Nobuharu Suzuki. The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins. Frontiers in Cell and Developmental Biology. 2022. 10. 952135
Chikako Hayashi, Momona Yamada, Miho Iwase, Nobuharu Suzuki. The regulation of axonal homeostasis by myelin: From studies with genetically engineered mice. 2021. 36. 4. 353-357
Nobuharu Suzuki, Miho Iwase, Momona Yamada. The mechanism of axon maintenance by myelin in the central nervous system. 2020. 9. 2. 103-109
Chikako Hayashi, Nobuharu Suzuki. Heterogeneity of Oligodendrocytes and Their Precursor Cells. Adv. Exp. Med. Biol. 2019. 1190. 53-62
Chikako Hayashi, Nobuharu Suzuki. Morphological and Functional Diversity of Oligodendrocytes in the Central Nervous System. Seikagaku. 2019. 91. 5. 701-705

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Lectures and oral presentations (63)：

赤血球コレステロール代謝の解析モデルとして使用する赤芽球系細胞の脂質輸送タンパク解析
(第63回日本臨床化学会年次学術集会学生シンポジウム1)
The Functional Analysis of ECM Proteins in Oligodendrocyte Development and Differentiation
(The 7th Annual Meeting of the Japan Myelin Society)
An extracellular matrix protein Fibulin-7 positively regulates oligodendrocyte differentiation through the N-terminal active sequence
(第45回日本分子生物学会年会)
Teneurin-4 promotes CNS myelin formation through a molecular interaction with actin-regulating proteins in oligodendrocytes
(第45回日本分子生物学会年会)
Teneurin-4 forms a molecular complex with actin-regulating proteins in oligodendrocytes and promotes myelin sheath formation in the CNS
(Neuroscience 2022)

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Work history (7)：

2018/04 - 2020/06 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Biomedical Sciences and Engineering Division of Biomedical Laboratory Sciences Department of Molecular and Cellular Biology Associate Professor
2014/02 - 2018/03 Tokyo Medical and Dental University Graduate School of Health Care Sciences Biomedical Laboratory Sciences Life Sciences and Bio-informatics Biochemistry and Biophysics Associate Professor
2010/09 - 2014/01 Tokyo Medical and Dental University Graduate School of Health Care Sciences Biomedical Laboratory Sciences Life Sciences and Bio-informatics Biochemistry and Biophysics Junior Associate Professor
2010/04 - 2010/08 NIDCR, NIH Research Fellow
2008/03 - 2010/04 NIDCR, NIH Visiting Fellow

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Awards (7)：

2023/10 - 日本臨床化学会清水梨帆,第63回日本臨床化学会学術集会 JSCC Student Award 赤血球コレステロール代謝の解析モデルとして使用する赤芽球系細胞の脂質輸送タンパク解析
2020/09 - The Japanese Society for Neurochemistry The Excellent Poster Presentation Award at the 63rd Annual Meeting of the Japanese Society for Neurochemistry The crucial role of teneurin-4 associated with actin binding protein CNP in myelination and axonal maintenance.
2020/09 - The Japanese Society for Neurochemistry The Excellent Poster Presentation Award at the 63rd Annual Meeting of the Japanese Society for Neurochemistry Teneurin-4 regulates the generation of type I/II oligodendrocytes that myelinate small diameter axons.
2020/03 - Tokyo Medical and Dental University The silver award at the pitch contest for cryo-EM gateway The molecular operation for cell adhesion based on structual anaysis
2018/09 - The Japanese Society for Neurochemistry The Excellent Presentation Award at the 61st Annual Meeting of the Japanese Society for Neurochemistry Teneurin-4 Mediates Oligodendrocyte-Axon Interaction and Regulates Myelination

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