Rchr
J-GLOBAL ID：201801014160476035
Update date: Jun. 16, 2024
Abe Yoshinori
Abe Yoshinori
Affiliation and department：
Job title：
Senior Assistant Professor
Research field (3)：
Pathobiochemistry
, Medical biochemistry
, Molecular biology
Research keywords (7)：
PRMT family
, 慢性炎症
, 腫瘍
, 癌
, 癌幹細胞
, Hedgehog
, シグナル伝達
Research theme for competitive and other funds (17)：
- 2023 - 2026 空間的な遺伝子解析によるケロイド発生機序の解明と新規治療標的の導出
- 2023 - 2026 Analysis of arginine methylation signal network in pancreatic cancer to develop the novel cancer therapeutic strategy
- 2021 - 2025 .
- 2022 - 2025 アルギニンメチル基転移酵素PRMT5による膵臓癌発症を制御する分子機構の解明
- 2020 - 2023 PRMT5による新たなケロイド幹細胞制御機構の解明と新治療薬開発への挑戦
- 2020 - 2023 Analysis of the mechanism of PRMT5-mediated pancreatic cancer stem cells maintenance, and development of therapeutic strategy targeting pancreatic cancer stem cells by PRMT5 inhibition
- 2020 - 2021 Establishment of therapeutic strategy for KRAS-mutant cancer targeting PRMT5-mediated cancer stem cells maintenance machinery
- 2020 - 2020 .
- 2017 - 2020 Elucidation of maintenance mechanism of mesenchymal stem cells in keloid to develop new therapy
- 2013 - 2016 The novel mechanisms of sonic hedgehog gene expression in the chronic inflammation induced cancer
- 2013 - 2014 がん化に関わる全く新しい細胞増殖シグナル伝達機構の解析(STAT3-MEP50を介した Gli1 活性化経路の細胞のがん化機構)
- 2013 - 2014 がん化に関わる全く新しい細胞増殖シグナル伝達機構の解析(STAT3-MEP50を介した Gli1 活性化経路の細胞のがん化機構)
- 2012 - 2013 癌化に関わる STAT3を介した新しい Hedgehog 経路活性化機構の解析
- 2009 - 2010 新規 Hedgehog シグナル伝達経路制御分子機構の解明
- 2008 - 2009 新規 Hedgehog シグナル伝達経路制御分子機構の解明
- 2005 - 2009 Analysis of the gene transcriptional network system regulated by nuclear tumor suppressive factors
- 2001 - 2002 Elucidation of cell proliferation control mechanism by the new serine-threonine kinase LATS2
Show all
Papers (21)：
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Yoshinori Abe, Takumi Sano, Naoki Otsuka, Masashi Ogawa, Nobuyuki Tanaka. PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth. Communications Biology. 2024. 7. 1
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Mamiko Tosa, Yoshinori Abe, Seiko Egawa, Tomoka Hatakeyama, Chihiro Iwaguro, Ryotaro Mitsugi, Ayaka Moriyama, Takumi Sano, Rei Ogawa, Nobuyuki Tanaka. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target. Communications biology. 2023. 6. 1. 1235-1235
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Yoshinori Abe, Takumi Sano, Nobuyuki Tanaka. The Role of PRMT5 in Immuno-Oncology. Genes. 2023. 14. 3. 678-678
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Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Yoshinori Abe, Ikuno Uehara, Makoto Watanabe, Yoshiaki Hashimoto, Yasuo Miyagi, Noriko Nagi-Miura, Nobuyuki Tanaka, et al. Statins Show Anti-Atherosclerotic Effects by Improving Endothelial Cell Function in a Kawasaki Disease-Like Vasculitis Mouse Model. International Journal of Molecular Sciences. 2022. 23. 24. 16108-16108
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Yoshinori Abe, Nobuyuki Tanaka. Fine-Tuning of GLI Activity through Arginine Methylation: Its Mechanisms and Function. Cells. 2020. 9. 9. 1973-1973
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MISC (31)：
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佐野匠, 佐野匠, 阿部芳憲, 田中信之. The role of STAT3-PRMT5 activation loop machinery in lung cancer cells. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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阿部芳憲, 田中信之. PRMT5 mediates cancer stemness and acquired drug resistance in EGFR-mutant non-small cell lung cancer. 日本癌学会学術総会抄録集(Web). 2020. 79th
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土佐眞美子, 阿部芳憲, 土肥輝之, 小川令. ケロイドにおけるVIII型コラーゲン遺伝子の発現解析. 日本形成外科学会基礎学術集会プログラム・抄録集. 2020. 29th
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阿部芳憲, 佐野匠, 田中信之. PRMT5はEGFR変異非小細胞癌において癌幹細胞維持と薬剤耐性獲得に関わる. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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阿部芳憲, 田中信之. 恒常的にhedgehogシグナル伝達経路が活性化した癌細胞におけるMEP50/PRMT5複合体の役割. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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Patents (1)：
Professional career (1)：
Work history (3)：
- 2024/04 - 現在 Nippon Medical School Laboratory of Molecular Analysis Senior Assistant Professor
- 2003/04 - 2024/03 Nippon Medical School Department of Molecular Oncology, Institute for Medical Sciences
- 2001/04 - 2003/03 日本学術振興会特別研究員(DC2)
Awards (1)：
- 2009/03 - 日本医科大学 日本医科大学賞 (研究部門)
Association Membership(s) (2)：
THE JAPANESE CANCER ASSOCIATION
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
