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J-GLOBAL ID：201801014286023559   Update date: Apr. 16, 2025

Obara Keisuke

オバラ ケイスケ | Obara Keisuke
Clips
Affiliation and department：
Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences

About Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (14)： フェルラ酸 ,  血小板活性化因子 ,  γ-リノレン酸 ,  精神疾患治療薬 ,  受容体 ,  アドレナリン受容体 ,  β-アドレナリン受容体 ,  下部尿路 ,  排尿機能 ,  膀胱平滑筋 ,  n-3系多価不飽和脂肪酸 ,  ドコサヘキサエン酸 ,  DHA ,  機能性食品
Research theme for competitive and other funds  (11)：
  • 2024 - 2027 n-3系PUFAはストア作動性Caチャネルを標的として気管平滑筋の収縮を抑制する
  • 2024 - 2027 フェルラ酸は血小板活性化因子(PAF)による膀胱平滑筋の過活動を改善する
  • 2023 - 2026 α-リノレン酸は脳動脈収縮を即時的かつDHA・EPAに匹敵するほど強力に抑制する
  • 2021 - 2024 下部泌尿器平滑筋の収縮機能異常に対するγ-リノレン酸の抑制効果の分子基盤
  • 2020 - 2023 Mechanisms which underlie the immediate inhibitory effects by n-3 polyunsaturated fatty acids of coronary artery contraction
Show all
Papers (55)：
  • Obara K*†, Takahashi S†, Otake M†, Fujiwara M†, Yamashita M†, Murata A†, Yoshioka K†, Tanaka Y†. Platelet-activating factor (PAF) induces strong mechanical activities accompanied by basal tension increases in esophageal and gastric fundus smooth muscles from rat. Biological & pharmaceutical bulletin. 2025. in press
  • Ge Liu, Hiryu Fujita, Hayato Agui, Ayu Kato, Miwa Enomoto, Futaba Makino, Nana Yamada, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka. Evidence Showing Bombesin-Like Peptides Contract Guinea Pig Vas Deferens Smooth Muscle. Biological and Pharmaceutical Bulletin. 2025. 48. 3. 298-307
  • Keisuke Obara, Yuki Usami, Risa Okamoto, Kento Yoshioka, Yoshio Tanaka. Evaluation of inhibitory actions of antidepressants on muscarinic receptors assessed by a binding assay in the mouse cerebral neocortex. Journal of Pharmacological Sciences. 2024. 156. 4. 214-217
  • Keisuke Obara, Kento Yoshioka, Yoshio Tanaka. Platelet-activating Factor (PAF) in Urinary Bladder Smooth Muscle (UBSM): Its Novel Role as a Potential Inducer of Detrusor Overactivity and the Mechanisms Underlying Its Effects in Enhancing UBSM Mechanical Activities. YAKUGAKU ZASSHI. 2024. 144. 11. 997-1007
  • Keisuke Obara, Kento Yoshioka, Yoshio Tanaka. Effects of Platelet-Activating Factor (PAF) on the Mechanical Activities of Lower Urinary Tract and Genital Smooth Muscles. Biological and Pharmaceutical Bulletin. 2024. 47. 9. 1467-1476
ｍore...
Books (1)：
  • パートナー薬理学
    南江堂 2024 ISBN:9784524404285
Lectures and oral presentations  (145)：
  • Evaluation of anti-muscarinic actions of antidepressants in the mouse cerebral cortex: binding studies to find out therapeutic drugs recommended for patients with Alzheimer's disease
    (2025)
  • Inhibitory effects of α-linoleic acid (ALA) on contractions in pig coronary arteries
    (2025)
  • 全身麻酔薬の薬理学的知識
    (第57回上総いちはら臨床薬学セミナー 2025)
  • 膀胱平滑筋の収縮に及ぼす因子の再考-脂質メディエーターの膀胱平滑筋に対する収縮効果とその機序-
    (第66回日本平滑筋学会総会 2024)
  • モルモット大動脈のフェニレフリンによる収縮反応機序-α<SUB>1L</SUB>-アドレナリン受容体とストア作動性Ca<SUP>2+</SUP>チャネル及び電位依存性Ca<SUP>2+</SUP>チャネルの機能的共役の可能性-
    (日本薬学会第144年会 2024)
ｍore...
Education (1)：
  • 2006 - 2012 Toho University Faculty of Pharmaceutical Sciences School of Pharmaceutical Sciences
Professional career (2)：
  • 学士(薬学) (東邦大学)
  • 博士(薬学) (東邦大学)
Work history (3)：
  • 2024/04 - 現在 Toho University Faculty of Pharmaceutical Sciences School of Pharmaceutical Sciences Associate Professor
  • 2018/04 - 2024/03 Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Lecturer
  • 2012/04 - 2018/03 Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Assistant Professor
Awards (4)：
  • 2023/03 - The Pharmaceutical Society of Japan The Most Published Author Award 2018-2022 in BPB
  • 2022/12 - 第96回日本薬理学会年会 優秀ポスター賞 Docosahexaenoic acid (DHA) selectively inhibits prostanoid TP receptor-mediated contractions of guinea pig tracheal smooth muscle
  • 2018/08 - 第60回日本平滑筋学会総会 ポスター賞
  • 2018/03 - 額田奨学金
Association Membership(s) (3)：
THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  JAPAN SOCIETY OF SMOOTH MUSCLE RESEARCH
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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