Rchr
J-GLOBAL ID：201801014404545921   Update date: Sep. 02, 2024

Ryota Shizu

シズ リョウタ | Ryota Shizu
Affiliation and department：
University of Shizuoka School of Pharmaceutical Sciences

About University of Shizuoka School of Pharmaceutical Sciences


Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (7)： 肝がん ,  脂質代謝 ,  薬物代謝酵素 ,  核内受容体 ,  転写調節 ,  転写共役因子 ,  転写因子
Research theme for competitive and other funds  (14)：
  • 2023 - 2026 ケム・バイオハイブリッド合成を鍵技術とした多分野連携型赤痢アメーバ治療薬開発
  • 2023 - 核内受容体PXRによる肝がん進行抑制作用の機序解明と創薬への応用
  • 2023 - 非遺伝毒性肝発がん性の核内受容体活性化プロファイルに基づく評価の有用性検討
  • 2021 - 2023 Understanding the influence of PXR activation on the epithelial mesenchymal transition of liver cancer cells
  • 2020 - 2023 PXRとCARによる肝成熟・肝機能調節に着目した薬物の次世代・遅発性影響の解析
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Papers (43)：
  • Takumi Sato, Ryota Shizu, Ryonosuke Baba, Akira Ooka, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari. Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression. Biochemical journal. 2024
  • Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, Kouichi Yoshinari. Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury. Xenobiotica. 2024
  • Ryota Shizu, Natsuki Makida, Keiichiro Sobe, Mai Ishimura, Aki Takeshita, Takuomi Hosaka, Yuichiro Kanno, Takamitsu Sasaki, Kouichi Yoshinari. Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation. Toxicological sciences : an official journal of the Society of Toxicology. 2023
  • Sawako Shindo, Satoru Kakizaki, Toshiyuki Sakaki, Yuki Kawasaki, Tsutomu Sakuma, Masahiko Negishi, Ryota Shizu. Phosphorylation of nuclear receptors: Novelty and therapeutic implications. Pharmacology & therapeutics. 2023. 248. 108477-108477
  • Wataru Murase, Atsuhito Kubota, Atsuko Ikeda-Araki, Masaru Terasaki, Koji Nakagawa, Ryota Shizu, Kouichi Yoshinari, Hiroyuki Kojima. Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays. Toxicology. 2023. 494. 153577-153577
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MISC (71)：
  • 佐藤拓海, 志津怜太, 保坂卓臣, 佐々木崇光, 菅野裕一朗, 吉成浩一. Mechanism of the nuclear receptor PXR-mediated suppression of transdifferentiation of hepatic stellate cells. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 志津怜太, 佐藤拓海, 三浦佳恵, 保坂卓臣, 菅野裕一朗, 佐々木崇光, 吉成浩一. Screening of nuclear receptor CAR and PPARα activation potential of chemicals which cause liver cancer in rat carcinogenicity test. 衛生薬学・環境トキシコロジー講演要旨集. 2022. 2022
  • 佐藤拓海, 志津怜太, 志津怜太, 馬場遼之介, 石村麻衣, 保坂卓臣, 保坂卓臣, 佐々木崇光, 菅野裕一朗, 菅野裕一朗, et al. Mechanism of the nuclear receptor PXR-mediated suppression of epithelial-mesenchymal transition of liver cancer cells. 日本薬学会年会要旨集(Web). 2022. 142nd
  • 馬場遼之介, 志津怜太, 佐藤拓海, 保坂卓臣, 菅野裕一朗, 吉成浩一. Evaluation of the influence of PXR activation on epithelial-mesenchymal transition of liver cancer cells using reporter assay with the VIMENTIN promoter. 衛生薬学・環境トキシコロジー講演要旨集. 2022. 2022
  • 佐藤拓海, 志津怜太, 志津怜太, 馬場遼之介, 石村麻衣, 保坂卓臣, 保坂卓臣, 佐々木崇光, 菅野裕一朗, 菅野裕一朗, et al. A mechanism for the nuclear receptor PXR-mediated suppression of liver cancer progression. Journal of Toxicological Sciences. 2022. 47. Supplement (CD-ROM)
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Lectures and oral presentations  (12)：
  • 異物応答性核内受容体PXR及びCARの機能解明と活性化評価系の構築
    (日本薬学会第143年会 2024)
  • Understanding the molecular mechanisms that cause species differences in CAR-dependent liver cancer promotion
    (ICCP450/JSSX meeting 2023)
  • Phosphorylation of Nuclear Receptor; Common Molecular Basis for Activation
    (ICCP450/JSSX meeting 2023)
  • Anti-inflammatory and immune functions of the xenobiotic responsive nuclear receptor PXR.
    (2022)
  • Identification of the underlying principle of species difference in the chemical liver carcinogenesis
    (2022)
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Education (2)：
  • - 2014 東北大学大学院 薬学研究科
  • - 2009 Showa University School of Pharmacy
Professional career (1)：
  • 博士(薬学) (東北大学)
Work history (4)：
  • 2023/07 - 現在 University of Shizuoka School of Pharmaceutical Sciences
  • 2017/04 - 2023/06 University of Shizuoka School of Pharmaceutical Sciences
  • 2016/03 - 2017/03 日本学術振興会 海外特別研究員(NIH)
  • 2014/04 - 2017/03 NIEHS/NIH 博士研究員
Committee career (2)：
  • 2024 - 現在 日本毒性学会 評議員
  • 2023/09 - 日本薬物動態学会第38回年会第23回シトクロムP450国際合同大会 実行委員長
Awards (11)：
  • 2023/09 - 日本薬学会環境・衛生部会 部会賞・金原賞
  • 2022/12 - 静岡県立大学 学長表彰
  • 2022/07 - 日本薬学会東海支部 学術奨励賞
  • 2022/07 - 日本毒性学会 田邊賞
  • 2022/07 - 日本毒性学会 奨励賞
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Association Membership(s) (6)：
THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS ,  THE JAPANESE SOCIETY OF TOXICOLOGY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  日本生化学会 ,  ISSX
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