2019 - 2022 Elucidation of the molecular mechanism of CYP3A4 induction in the human intestine and its differences from the liver
2021 - 上皮間葉転換に注目した肝がんの進行を抑制する医薬品のスクリーニングと治療効果の検証
2019 - 2021 Identification of the molecular mechanism of nuclear receptor CAR-mediated liver carcinogenesis and its species differences.
2017 - 2020 Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevance
2017 - 2020 Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors
2020 - 核内受容体 CAR のヒト型変異導入マウスを用いた肝発がんプロモーションの機序解析
2017 - 2019 Establishment of in vitro evaluation system for the activation of nuclear receptor CAR and PXR
Show all
Papers (69):
Wataru Murase, Atsuhito Kubota, Ryo Hakota, Ayaka Yasuda, Atsuko Ikeda, Koji Nakagawa, Ryota Shizu, Kouichi Yoshinari, Hiroyuki Kojima. Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA. Toxicology. 2025
Naoya Watanabe, Yukiko K. Kaneko, Hisamitsu Ishihara, Ryota Shizu, Kouichi Yoshinari, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa. Diacylglycerol kinase ζ is a positive insulin secretion regulator in pancreatic β-cell line MIN6. Biochemical and Biophysical Research Communications. 2025
Takumi Sato, Ryota Shizu, Ryonosuke Baba, Akira Ooka, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari. Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression. Biochemical journal. 2024
Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, Kouichi Yoshinari. Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury. Xenobiotica. 2024
UCHIDA Nana, HARAKAWA Yu, HOSAKA Takuomi, SHIZU Ryota, TAKESHITA Jun-ichi, YOSHINARI Kouichi. Quantitative relationships between the LOEL values for hepatotoxicity and cytochrome P450-inhibitory activity of chemical substances. Annual Meeting of the Japanese Society of Toxicology. 2024. 51.1. P-130S
竹下明希, 志津怜太, 牧田夏希, 保坂卓臣, 吉成浩一. The xenoresponsive nuclear receptor CAR regulates Gadd45b transcription via CpG island demethylation. 日本薬学会年会要旨集(Web). 2024. 144th
高村真弥, 大村奈央, 保坂卓臣, 志津怜太, 竹下潤一, 竹下潤一, 吉成浩一. Development of a read-across method for evaluating developmental neurotoxicity using molecular descriptors. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
鈴木浩章, 原川ゆう, 高村真弥, 水野航介, 保坂卓臣, 志津怜太, 吉成浩一. Identification of toxicologically important findings in rat repeated-dose toxicity studies of pesticides. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
2023/07 - 現在 University of Shizuoka School of Pharmaceutical Sciences
2017/04 - 2023/06 University of Shizuoka School of Pharmaceutical Sciences
2016/03 - 2017/03 日本学術振興会 海外特別研究員(NIH)
2014/04 - 2017/03 NIEHS/NIH 博士研究員
Committee career (2):
2024 - 現在 日本毒性学会 評議員
2023/09 - 日本薬物動態学会第38回年会第23回シトクロムP450国際合同大会 実行委員長
Awards (11):
2023/09 - 日本薬学会環境・衛生部会 部会賞・金原賞
2022/12 - 静岡県立大学 学長表彰
2022/07 - 日本薬学会東海支部 学術奨励賞
2022/07 - 日本毒性学会 田邊賞(論文賞)
2022/07 - 日本毒性学会 奨励賞
2021/10 - The 80th Annual Meeting of the Japanese Cancer Association Poster award PXR activation might attenuate the liver cancer development by preventing EMT of liver cancer cells
2019/07 - 12th International ISSX Meeting (Portland, OR) Postdoctoral Poster award 3rd Place
2019/06 - 日本毒性学会 田邊賞(論文賞)
2019/01 - 日本毒性学会第1回医薬品毒性機序研究会(名古屋) 優秀発表賞
2016/10 - The 21st International Symposium on Microsomes and Drug Oxidations (Davis, CA) Best poster award
2015/07 - Gordon Research Conference (Drug Metabolism) (Holderness, NH) Travel grant
Show all
Association Membership(s) (6):
THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, THE JAPANESE SOCIETY OF TOXICOLOGY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, 日本生化学会
, ISSX