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J-GLOBAL ID：201801014404545921   Update date: Jan. 23, 2025

Ryota Shizu

シズ リョウタ | Ryota Shizu
Affiliation and department：
University of Shizuoka School of Pharmaceutical Sciences

About University of Shizuoka School of Pharmaceutical Sciences


Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (7)： 肝がん ,  脂質代謝 ,  薬物代謝酵素 ,  核内受容体 ,  転写調節 ,  転写共役因子 ,  転写因子
Research theme for competitive and other funds  (14)：
  • 2023 - 2026 ケム・バイオハイブリッド合成を鍵技術とした多分野連携型赤痢アメーバ治療薬開発
  • 2023 - 核内受容体PXRによる肝がん進行抑制作用の機序解明と創薬への応用
  • 2023 - 非遺伝毒性肝発がん性の核内受容体活性化プロファイルに基づく評価の有用性検討
  • 2021 - 2023 Understanding the influence of PXR activation on the epithelial mesenchymal transition of liver cancer cells
  • 2020 - 2023 PXRとCARによる肝成熟・肝機能調節に着目した薬物の次世代・遅発性影響の解析
Show all
Papers (69)：
  • Wataru Murase, Atsuhito Kubota, Ryo Hakota, Ayaka Yasuda, Atsuko Ikeda, Koji Nakagawa, Ryota Shizu, Kouichi Yoshinari, Hiroyuki Kojima. Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA. Toxicology. 2025
  • Naoya Watanabe, Yukiko K. Kaneko, Hisamitsu Ishihara, Ryota Shizu, Kouichi Yoshinari, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa. Diacylglycerol kinase ζ is a positive insulin secretion regulator in pancreatic β-cell line MIN6. Biochemical and Biophysical Research Communications. 2025
  • Takumi Sato, Ryota Shizu, Ryonosuke Baba, Akira Ooka, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari. Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression. Biochemical journal. 2024
  • Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, Kouichi Yoshinari. Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury. Xenobiotica. 2024
  • UCHIDA Nana, HARAKAWA Yu, HOSAKA Takuomi, SHIZU Ryota, TAKESHITA Jun-ichi, YOSHINARI Kouichi. Quantitative relationships between the LOEL values for hepatotoxicity and cytochrome P450-inhibitory activity of chemical substances. Annual Meeting of the Japanese Society of Toxicology. 2024. 51.1. P-130S
ｍore...
MISC (98)：
  • 糀本祐樹, 志津怜太, 生駒和希, 佐藤拓海, 保坂卓臣, 吉成浩一. Search for marker genes for chemical-induced nuclear receptor activation-dependent liver carcinogenesis promotion effects. 日本薬学会年会要旨集(Web). 2024. 144th
  • 竹下明希, 志津怜太, 牧田夏希, 保坂卓臣, 吉成浩一. The xenoresponsive nuclear receptor CAR regulates Gadd45b transcription via CpG island demethylation. 日本薬学会年会要旨集(Web). 2024. 144th
  • 皆藤駿之介, 岩田実咲, 保坂卓臣, 志津怜太, 竹下潤一, 竹下潤一, 吉成浩一. 主成分分析を用いた層別化による肝障害誘発性薬物の化学構造と毒性発現機序の関連性解析. HAB研究機構学術年会プログラム・要旨集. 2023. 30th
  • 高村真弥, 大村奈央, 保坂卓臣, 志津怜太, 竹下潤一, 竹下潤一, 吉成浩一. Development of a read-across method for evaluating developmental neurotoxicity using molecular descriptors. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
  • 鈴木浩章, 原川ゆう, 高村真弥, 水野航介, 保坂卓臣, 志津怜太, 吉成浩一. Identification of toxicologically important findings in rat repeated-dose toxicity studies of pesticides. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
ｍore...
Lectures and oral presentations  (13)：
  • 核内受容体CARの肝細胞増殖誘導に関する機序の理解
    (第7回医薬品毒性機序研究会 2025)
  • 異物応答性核内受容体PXR及びCARの機能解明と活性化評価系の構築
    (日本薬学会第143年会 2024)
  • Understanding the molecular mechanisms that cause species differences in CAR-dependent liver cancer promotion
    (ICCP450/JSSX meeting 2023)
  • Phosphorylation of Nuclear Receptor; Common Molecular Basis for Activation
    (ICCP450/JSSX meeting 2023)
  • Anti-inflammatory and immune functions of the xenobiotic responsive nuclear receptor PXR.
    (2022)
ｍore...
Education (2)：
  • - 2014 東北大学大学院 薬学研究科
  • - 2009 Showa University School of Pharmacy
Professional career (1)：
  • 博士(薬学) (東北大学)
Work history (4)：
  • 2023/07 - 現在 University of Shizuoka School of Pharmaceutical Sciences
  • 2017/04 - 2023/06 University of Shizuoka School of Pharmaceutical Sciences
  • 2016/03 - 2017/03 日本学術振興会 海外特別研究員(NIH)
  • 2014/04 - 2017/03 NIEHS/NIH 博士研究員
Committee career (2)：
  • 2024 - 現在 日本毒性学会 評議員
  • 2023/09 - 日本薬物動態学会第38回年会第23回シトクロムP450国際合同大会 実行委員長
Awards (11)：
  • 2023/09 - 日本薬学会環境・衛生部会 部会賞・金原賞
  • 2022/12 - 静岡県立大学 学長表彰
  • 2022/07 - 日本薬学会東海支部 学術奨励賞
  • 2022/07 - 日本毒性学会 田邊賞(論文賞)
  • 2022/07 - 日本毒性学会 奨励賞
Show all
Association Membership(s) (6)：
THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS ,  THE JAPANESE SOCIETY OF TOXICOLOGY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  日本生化学会 ,  ISSX
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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