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J-GLOBAL ID:201801014763324663   Update date: Dec. 12, 2024

MIYAGAWA TAKU

MIYAGAWA TAKU
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Affiliation and department:
Research field  (1): Genetics
Research theme for competitive and other funds  (13):
  • 2024 - 2027 Elucidating the pathogenesis of narcolepsy through short- and long-read single-cell RNA sequencing
  • 2022 - 2026 DNAメチル化異常がもたらすナルコレプシー発症機構の解明
  • 2021 - 2024 フェノムワイド関連解析及び日本人特異的変異による過眠症の分子基盤の解明
  • 2019 - 2022 メタボローム・ゲノム解析を中心としたナルコレプシーの病態解明と個別化医療への応用
  • 2015 - 2019 Searching for susceptibility genes for narcolepsy, and their application for precision medicine
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Papers (70):
  • Mihoko Shimada, Makoto Honda, Yoshiko Honda, Tohru Kodama, Yuki Hitomi, Katsushi Tokunaga, Taku Miyagawa. Multiomics analysis of narcolepsy T cells: global hypomethylation in solo-WCGW motif linked to T cell proliferation. 2024
  • Mihoko Shimada, Yosuke Omae, Akiyoshi Kakita, Ramil Gabdulkhaev, Yuki Hitomi, Taku Miyagawa, Makoto Honda, Akihiro Fujimoto, Katsushi Tokunaga. Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing. Science advances. 2024. 10. 4. eadj5279
  • Kugui Yoshida-Tanaka, Mihoko Shimada, Yoshiko Honda, Akihiro Fujimoto, Katsushi Tokunaga, Makoto Honda, Taku Miyagawa. Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region. Scientific reports. 2023. 13. 1. 10464-10464
  • Hanna M Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati, Selina M Yogeshwar, Ryan P Hillary, Otto Jolanki, Juliette Faraco, Mali Einen, et al. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. Nature communications. 2023. 14. 1. 2709-2709
  • Makoto Honda, Yosuke Shigematsu, Mihoko Shimada, Yoshiko Honda, Katsushi Tokunaga, Taku Miyagawa. Low carnitine palmitoyltransferase1 activity is a risk factor for narcolepsy type 1 and other hypersomnia. Sleep. 2022
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MISC (18):
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Awards (3):
  • 2020/09 - 日本睡眠学会 第24回日本睡眠学会研究奨励賞論文
  • 2013 - 日本人類遺伝学会 奨励賞
  • 2011 - 日本人類遺伝学会 JHG賞
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