Research theme for competitive and other funds (5)：
2021 - 2024 共通病態を基盤とした高安動脈炎と潰瘍性大腸炎を包括する新規症候群の検討
2017 - 2020 Development of a new rheumatoid arthritis monitoring method by analysis of anti-CCP antibody-producing B cell repertoire
2018 - 2020 解糖系酵素ピルビン酸キナーゼM2による炎症性疾患の制御
2016 - 2017 新規自己抗体による高安動脈炎の病態解明と臨床応用
2013 - 2015 脳症を呈する膠原病患者における抗EphB2抗体の臨床的・病原的意義の解明
Papers (82)：
Sae Shirota, Tsuyoshi Shirai, Kentaro Mori, Jun Inoue, Hiroko Sato, Tomonori Ishii, Hiroshi Fujii. Comment on: A case of vanishing bile duct syndrome during treatment of microscopic polyangiitis with avacopan. Rheumatology (Oxford, England). 2024. 63. 4. e149-e150
Maya Yamato, Tsuyoshi Shirai, Yusho Ishii, Hiroko Sato, Tomonori Ishii, Hiroshi Fujii. Impact of subcutaneous belimumab on disease activity, patient satisfaction, and metabolic profile in long-lasting systemic lupus erythematosus. Clinical Rheumatology. 2024
Ken Yasaka, Tomohide Yamazaki, Hiroko Sato, Tsuyoshi Shirai, Minkwon Cho, Koji Ishida, Koyu Ito, Tetsuhiro Tanaka, Kouetsu Ogasawara, Hideo Harigae, et al. Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus. Arthritis research & therapy. 2023. 25. 1. 200-200
Tsuyoshi Shirai, Satoshi Watanabe, Natsuko O. Shinozaki, Kairi Baba, Hiroyuki Yamasaki, Tomonori Ishii, Hiroshi Fujii. Common dysbiosis features between patients of different social environments in Takayasu arteritis: comment on the article by Fan et al. Arthritis & Rheumatology. 2023. 75. 7. 1291-1292
Maya Yamato, Tsuyoshi Shirai, Hiroko Sato, Tomonori Ishii, Hiroshi Fujii. First reported case of pulmonary arteritis in patients with relapsing polychondritis. Rheumatology. 2023
Tsuyoshi Shirai, Tomoyuki Mutoh, Tomonori Ishii, Hiroshi Fujii, Hideo Harigae. IDENTIFICATION OF ENDOTHELIAL PROTEIN C RECEPTOR AND SCAVENGER RECEPTOR CLASS B TYPE 1 AS MAJOR AUTOANTIGENS IN TAKAYASU ARTERITIS. ANNALS OF THE RHEUMATIC DISEASES. 2019. 78. 437-438
Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
(Nature Communications 2020)
Endothelial Protein C Receptor and Scavenger Receptor Class B Type 1 Negatively Regulate Vascular Inflammation and Are Major Autoantigens in Takayasu Arteritis
(American College of Rheumatology Annual Meeting 2019 2019)
