MASUDA Mitsuharu

Research field (1)： Molecular biology

Research theme for competitive and other funds (5)：

2019 - 2021 Basic research for prevention of arteriosclerosis by cancer preventive ingredients with RB activation ability
2018 - 2021 New Cancer Prevention Strategy; Targeting abnormal cancer suppressor genes
2015 - 2019 Application of molecular-targeting cancer prevention to human intervention study.
2015 - 2017 Elucidation of mechanism of exacerbation by smoking in intervention study for cancer prevention
2013 - 2015 Towards realization of molecular-targeting cancer prevention; an attempt to develop safe and effective juice for cancer chemoprevention

Papers (23)：

Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023. 66. 22. 15171-15188
Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai. Discovery of cancer-preventive juices reactivating RB functions. Environmental health and preventive medicine. 2023. 28. 54-54
Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, et al. Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS medicinal chemistry letters. 2022. 13. 10. 1568-1573
Motoki Watanabe, Shogen Boku, Kaito Kobayashi, Yoichi Kurumida, Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, Chikage Kato, Yosuke Iizumi, Kiichi Hirota, et al. A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5. PNAS nexus. 2022. 1. 2. pgac059

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MISC (28)：

増田光治, 堀中真野, 安田周祐, 森田美枝, 西幹栄美, 石川秀樹, 武藤倫弘, 酒井敏行. RB再活性化ジュースの発見(Discovery of RB-reactivating juices). 日本癌学会総会記事. 2023. 82回. 1439-1439
Itoh, Yukihiro, Zhan, Peng, Tojo, Toshifumi, Jaikhan, Pattaporn, Ota, Yosuke, Suzuki, Miki, Li, Yin, Hui, Zi, Moriyama, Yukiko, Oba, Makoto, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of Medicinal Chemistry. 2023
Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai. Discovery of cancer-preventive juices reactivating RB functions. Environmental Health and Preventive Medicine. 2023. 28. 54-54
Motoki Watanabe, Shogen Boku, Kaito Kobayashi, Yoichi Kurumida, Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, Chikage Kato, Yosuke Iizumi, Kiichi Hirota, et al. A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5. PNAS Nexus. 2022. 1. 2
Ota, Yosuke, Itoh, Yukihiro, Kurohara, Takashi, Singh, Ritesh, Elboray, Elghareeb, Hu, Chenliang, Zamani, Farzad, Mukherjee, Anirban, Takada, Yuri, Yamashita, Yasunobu, et al. Cancer Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS Medicinal Chemistry Letters. 2022

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