Oda Akifumi

Research field (3)： Pharmaceuticals - analytical and physicochemistry , Biophysics , Basic physical chemistry

Research theme for competitive and other funds (8)：

2017 - 2020 薬物代謝酵素の動的構造揺らぎがリガンドおよび水分子の認識に与える影響
2015 - 2018 Phosphorylase phosphorylation in the heart failure development
2015 - 2017 限られたアミノ酸のみから原始タンパク質が構築できるか?
2014 - 2017 Influence of genetic polymorphism on three-dimensional structure and structural flexibility of drug metabolizing enzyme
2013 - 2016 Application of chemical biology to a mechanistic study of human nucleotide excision repair

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Papers (126)：

Ayato Mizuno, Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. Computational Estimation of Residues Involving Resistance to the SARS-CoV-2 Main Protease Inhibitor Ensitrelvir Based on Virtual Alanine Scan of the Active Site. Biological and Pharmaceutical Bulletin. 2024. 47. 5. 967-977
Koichi Kato, Tomoki Nakayoshi, Yasuro Shinohara, Eiji Kurimoto, Akifumi Oda, Yoshinobu Ishikawa. Theoretical Studies on the Reaction Mechanism of Schiff Base Formation from Hexoses. The Journal of Physical Chemistry B. 2024. 128. 20. 4952-4958
Koichi Kato, Tomoki Nakayoshi, Sho Hioki, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda. Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations. Biological and Pharmaceutical Bulletin. 2024. 47. 3. 620-628
Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. Three-dimensional structure prediction of [GADS]-proteins as tentative primitive proteins. Chemistry Letters. 2024
Yu Sato, Eiji Hishinuma, Shuki Yamazaki, Akiko Ueda, Masaki Kumondai, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, et al. Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8,380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation. Drug metabolism and disposition: the biological fate of chemicals. 2023

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MISC (94)：

山崎柊紀, 菱沼英史, 菱沼英史, 上田昭子, 前川正充, 前川正充, 前川正充, 佐藤裕, 公文代將希, 眞野成康, et al. Functional characterization of CYP2B6 rare variants identified in 8,380 Japanese individuals. 日本薬学会年会要旨集(Web). 2023. 143rd
小田彰史, 仲吉朝希. 生体内で起こる「美しくない」化学反応生体内非酵素的反応のコンピュータによる解析. ファルマシア. 2021. 57. 6. 500-504
平塚真弘, 平塚真弘, 平塚真弘, 平塚真弘, 公文代將希, 公文代將希, GUTIERREZ Evelyn, 菱沼英史, 菱沼英史, 上田昭子, et al. バイオバンク情報を活用した40種のCYP3A4バリアントにおける機能変化解析. 日本人類遺伝学会大会プログラム・抄録集. 2021. 66th (CD-ROM)
公文代將希, Gutierrez Evelyn, 菱沼英史, 齋藤さかえ, 田高周, 木下賢吾, 前川正充, 三枝大輔, 仲吉朝希, 小田彰史, et al. 日本人4776人の全ゲノム解析により同定された18種のCYP3A4遺伝子多型に由来するバリアント酵素の機能変化解析. 臨床薬理. 2020. 51. Suppl. S302-S302
仲吉朝希, 鰐田皓太, 加藤紘一, 栗本英治, 小田彰史. 酵素非存在下においてもアスパラギン残基の脱アミド化は進行する酢酸による触媒機序の量子化学計算. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [1Z11-580)]

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Education (3)：

Professional career (1)：

Work history (10)：

2016/04 - 現在 Meijo University Comprehensive Research Institute
2016/04 - 現在 Meijo University Faculty of Pharmacy Professor
2015/04 - 2016/03 Kanazawa University Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative
2012/04 - 2016/03 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Associate Professor
2014/04 - 2015/03 Osaka University Institute for Protein Research Guest Associate Professor

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Awards (4)：

2014/11 - Division of Chemoinformatics, The Chemical Society of Japan JCAC award
2013/09 - The D-Amino Acid Research Society Young Investigator Award
2010/12 - Tohoku Branch, The Pharmaceutical Society Japan Award for Young Scientists
2005/08 - Chem-Bio Informatics Society Award for the excellent poster

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