Koseki Masahiro

コセキマサヒロ | Koseki Masahiro

Affiliation and department：
Job title： Assistant Professor

Research field (7)： Cardiology , Cardiology , Metabolism and endocrinology , Metabolism and endocrinology , Gastroenterology , Nutrition and health science , Nutrition and health science

Research keywords (14)： nutritional guidance , metabolic cardiomyopathy , non-alcoholic steatohepatitis , sitosterolemia , familial hypercholesterolemia , Tangier disease , Apolipoprotein deficiency , 7-ketocholesterol , steatohepatitis-related cardiomyopathy , intestinal lipid absorption , nucleic acid medicine , lipid metabolism , high density lipoprotein , atherosclerosis

Research theme for competitive and other funds (10)：

2023 - 2026 Study of the development of guidelines and systems for healthcare service to contribute to secondary and tertiary prevention of atherosclerotic cardiovascular diseases followed by fatty liver-related diseases
2023 - 2026 Elucidation of the mechanism of fatty liver progression through regulation of lipid receptors and glucose transporters by PGRMC1
2022 - 2025 シトステロール血症の若年性動脈硬化惹起メカニズムの解明
2021 - 2024 原発性脂質異常症に関する調査研究
2020 - 2023 An exploration for biomarkers for predicting heart failure prognosis by the human olfactory-based odor analysis technology

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Papers (146)：

Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Hiroshi Sawabe, Hiroyasu Inui, Ayami Saga, Takeshi Okada, Tomoaki Higo, Tohru Ohama, et al. Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins. Journal of Atherosclerosis and Thrombosis. 2024
Hiroyuki Miura, Masahiro Koseki, Seiko Ide, Yasuhide Asaumi, Yoshiaki Morita, Yasutoshi Ohta, Katsunao Tanaka, Takeshi Okada, Takashi Omatsu, Soshiro Ogata, et al. Stronger positive correlation of the left ventricular mass index and extracellular volume fraction with diastolic function in diabetic patients without myocardial infarction. International Journal of Cardiology. 2024. 408. 132099-132099
Yoshimitsu Tanaka, Norikazu Maeda, Masahiro Koseki, Kazuhisa Maeda. Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol. 2024. 13. 7. 1860-1860
Yasuhisa Furuta, Yoshinori Osaki, Yoshimi Nakagawa, Song-Iee Han, Masaya Araki, Akito Shikama, Nami Ohuchi, Daichi Yamazaki, Erika Matsuda, Seitaro Nohara, et al. Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia. Journal of Atherosclerosis and Thrombosis. 2024
Tomonori Okamura, Kazuhisa Tsukamoto, Hidenori Arai, Yoshio Fujioka, Yasushi Ishigaki, Shinji Koba, Hirotoshi Ohmura, Tetsuo Shoji, Koutaro Yokote, Hiroshi Yoshida, et al. Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022. Journal of Atherosclerosis and Thrombosis. 2023

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MISC (193)：

小関正博, 秋葉庸平. 新時代を迎えた脂質管理のエビデンスと展望脂質異常症に対するANGPTL3阻害薬の可能性. 日本心臓病学会学術集会抄録. 2022. 70回. S5-3
伊藤香緒里, 小関正博. 来たれ迷える大学院生、若手研究者最新研究TECH-Seminar 3 LC-MS/MSを用いた酸化ステロール・植物ステロールの測定について. 日本動脈硬化学会総会プログラム・抄録集. 2022. 54回. 125-125
小関正博, Okada Takeshi, Nishida Makoto, Saga Ayami, Tanaka Katsunao, Omatsu Takeshi, Inui Hiroyasu, Nishihara Sae, Ohama Tohru, Kujiraoka Takeshi, et al. 原発性脂質異常でありかつ重症動脈硬化症の強力なリスク因子としてのFHのスクリーニングと治療について遺伝子診断に基づいた適切なFH治療の提供(Appropriate Treatment of Familial Hypercholesterolemia Based on Genetic Diagnosis). 日本動脈硬化学会総会プログラム・抄録集. 2022. 54回. 131-131
田中克尚, 小関正博, 岡田健志, 冠野昂太郎, 常久洋, 嵯峨礼美, 尾松卓, 乾洋勉, 大濱透, 西田誠, et al. 脂質異常症と脂肪肝のクロストークスタチンとペマフィブラートの併用療法による肝臓内脂質および炎症に及ぼす影響の検討. 日本動脈硬化学会総会プログラム・抄録集. 2022. 54回. 155-155
北尾隆, 小関正博, 白記達也, 岡田健志, 溝手勇, 大谷朋仁, 彦惣俊吾, 中谷大作, 坂田泰史. LDLコレステロール100mg/dl未満の管理下で経皮的冠動脈インターベンションを施行された慢性冠症候群患者の予後と非絶食non HDLコレステロールの関連の検証. 日本動脈硬化学会総会プログラム・抄録集. 2022. 54回. 197-197

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Books (1)：

CARDIO-HEPATOLOGY Connections Between Hepatic and Cardiovascular Disease
Elsevier 2022 ISBN:9780128173947

Lectures and oral presentations (183)：

Development of a Dietary and Nutritional Strategy to Reduce Plant Sterol Intake for “Sitosterolemia”
(2024)
The Existence of Psoriasis-like Dermatitis Promotes Atherosclerosis in Mice
(第88回日本循環器学会学術集会 2024)
Investigation of the causative relationship between lipid accumulation and renal dysfunction and the effect of SGLT2 inhibitor on renal dysfunction
(第88回日本循環器学会学術集会 2024)
LC-MS/MS analysis of sterol derivatives in patients with MASLD/MASH
(第88回日本循環器学会学術集会 2024)
The twin study: the factors affecting serum LDL C and HDL C levels and RNA seq analysis in mononuclear cells in monozygotic twins
(第88回日本循環器学会学術集会 2024)

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Education (2)：

- 2007 Osaka University Graduate School of Medicine Division of Medical Sciences
- 1996 Ehime University Faculty of Medicine 医学科

Professional career (1)：

医学博士 (大阪大学大学院)

Work history (11)：

2018/10 - 現在 Osaka University Graduate School of Medicine Cardiovascular Medicine assistant professor
2018/01 - 現在 Osaka University Graduate School of Medicine Cardiovascular Medicine assistant professor
2017/04 - 2017/12 Osaka University Graduate School of Medicine Health Care Division, Health and Counseling Center assistant professor
2015/04 - 2017/03 Osaka University Graduate School of Medicine Health Care Center assistant professor
2013/04 - 2015/03 Osaka University Graduate School of Medicine Cardiovascular Medicine 特任研究員

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Committee career (9)：

2022/12 - 現在日本動脈硬化学会研究者育成部会部会長
2020/12 - 現在日本臨床栄養協会薬局・薬剤師活動委員会
2020/12 - 現在日本臨床栄養協会在宅・プライマリーケア委員会
2020/03 - 現在日本臨床栄養協会評議員
2020/03 - 現在日本動脈硬化学会動脈硬化診療・疫学委員会( ガイドライン委員会)委員

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Association Membership(s) (13)：

日本糖尿病学会 , 日本心臓病学会 , The European Society of Cardiology , 日本肝臓学会 , 日本臨床栄養協会 , 日本脂質生化学会 , Japanese Association of Cardiovascular Intervention and Therapeutics , American Heart Association , 日本核酸医薬学会 , 日本再生医療学会 , 日本動脈硬化学会 , 日本循環器学会 , 日本内科学会

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