Research theme for competitive and other funds (40)：
2024 - 2028 Analysis of genomic DNA in aging heart
2024 - 2027 DUX4-flによる非遺伝子領域からの翻訳に着目したFSHDの病態解明
2023 - 2027 Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
2023 - 2027 Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
2023 - 2026 Determination of chronic or intractable mechanisms induced by low bone quality with osteomacs and bone marrow derived stem cells interaction
2022 - 2026 Understanding of pathophysiology and development of treatment strategy for MRONJ based on the hierarchical structure of macrophages
2022 - 2026 Understanding of pathophysiology and establishment of new treatment strategy by determining the hierarchy of macrophages in medication-related osteonecrosis of the jaw
2017 - 2020 Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment
2016 - 2019 The proposal of novel experimental system using original knockdown methods in mice
2016 - 2019 Development of microinjection-independent animal genome manipulation method
2016 - 2019 Role of calcium sensing receptor in Kidney Type B Intercalated Cells
2016 - 2019 Development of gene therapy for liver cirrhosis utilizing MMP13
2017 - 2019 Development of novel gene therapy strategy by insertion of artificial miRNA sequence into intronic region of endogenous gene(Fostering Joint International Research)
2016 - 2018 Screening of novel podocyte protective reagents using nephrin reporter mice
2015 - 2018 The RNA-based mechanism and function underlying molecular diversity in the nervous system
2015 - 2018 Transplantation effect of ADSC and SVF cells on ARONJ-like lesions in mice
2015 - 2018 Development of novel method for generation of genome editing mice without ex vivo handling of embryos
2013 - 2018 Foxc1/2 transcription factors and glomerulosclerosis
2014 - 2017 Bone marrow-derived fibrocytes and/or macrophages interact with oral cancer cells and stimulate the malignant progression of cancer cells
2013 - 2016 Development and verification of the next generation transgenesis tools
2013 - 2016 Analysis for homing mechanism of mesenchymal stem cells on functionally graded nanohybrid titanium dental implant
2012 - 2015 Analysis for the function of the candidate gene of Sick House Syndrome and development of disease model mouse
2010 - 2015 HLA genome diversity analyses by resequencing
2011 - 2013 Elucidation of molecular mechanisms underlying homing and mobilization of bone marrow-derived mesenchymal stem cells into oral and maxillofacial tissues
2011 - 2012 Development of conditional expression system in mice generated by site-specific gene integration method
2011 - 2012 Research for the molecular mechanism of Behcet's disease
2007 - 2011 Genome-wide identification of genes for anorexia and their cascade analysis on disease development by functional study
2008 - 2010 Development and application of novel transgenic technology by in vivo RMCE
2004 - 2005 疾患感受性ハプロタイプを検証する為の新規BACトランスジェニック手法の開発
2004 - 2005 ヒト少量血液からの対象ゲノム領域クローニング新手法の開発
1998 - 1999 ポジショナルクローニングによるメダカ突然変異体Daの原因遺伝子の単離
Show all
Papers (134)：
Hiromi Miura, Ayaka Nakamura, Aki Kurosaki, Ai Kotani, Masaru Motojima, Keiko Tanaka, Shigeru Kakuta, Sanae Ogiwara, Yuhsuke Ohmi, Hirotaka Komaba, et al. Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT. BMC Genomics. 2024. 25. 1
Kota Tsuruya, Keiko Yokoyama, Yusuke Mishima, Kinuyo Ida, Takuma Araki, Satsuki Ieda, Masato Ohtsuka, Yutaka Inagaki, Akira Honda, Tatehiro Kagawa, et al. Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletion. Journal of Lipid Research. 2024. 100616-100616
Masahiro Sato, Kazunori Morohoshi, Masato Ohtsuka, Shuji Takabayashi, Emi Inada, Issei Saitoh, Satoshi Watanabe, Shingo Nakamura. Recent Advances in the Production of Genome-Edited Animals Using <i>i</i>-GONAD, a Novel <i>in vivo</i> Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems. OBM Genetics. 2023. 07. 04. 1-30
Hirotaka Iura, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Masatake Tanaka, Kazuhiro Hata, Tetsuya Tamaru, Yohei Haruta, Gentaro Ono, Kazuki Kitade, et al. Bone marrow-derived fibroblast migration via periostin causes irreversible arthrogenic contracture after joint immobilization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 5. e22842
Masato Ohtsuka, Jurai Imafuku, Shuho Hori, Aki Kurosaki, Ayaka Nakamura, Tsubasa Nakahara, Takashi Yahata, Kolari Bhat, Steven T Papastefan, So Nakagawa, et al. Delivering mRNAs to mouse tissues using the SEND system. bioRxiv : the preprint server for biology. 2023
1997 - 2000 Nagoya University Graduate School of Science
1995 - 1997 Nagoya University Graduate School of Science
1991 - 1995 Yokohama National University School of Education
Work history (10)：
2019/04 - 現在 Tokai University School of Medicine Professor
2014/04 - 2019/03 Tokai University School of Medicine Associate Professor
2018/04 - 2018/10 University of Georgia College of Pharmacy Visiting Professor
2010/04 - 2014/03 Tokai University School of Medicine Assistant Professor
2009/04 - 2010/03 Tokai University Institute of Medical Sciences Assistant Professor
2008/07 - 2009/03 Tokai University Institute of Medical Sciences Assistant Professor
2003/04 - 2008/06 Tokai University School of Medicine Assistant Professor
2000/04 - 2003/03 Tokai University School of Medicine Postdoctoral Research Fellow
2002/01 - 2002/03 European Molecular Biology Laboratory (EMBL) Visitor Scientist
1998/04 - 2000/03 Japan Society for the Promotion of Science (JSPS) Research Fellow (DC2)
Show all
Association Membership(s) (6)：
American Society of Gene & Cell Therapy
, International Society for Transgenic Technologies
, SOCIETY FOR REPRODUCTION AND DEVELOPMENT
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, The Japanese Society for Genome Editing
, JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
