Rchr
J-GLOBAL ID:201801016723668591
Update date: Jan. 03, 2025 SASATANI MEGUMI
ササタニ メグミ | SASATANI MEGUMI
Affiliation and department: Research field (4):
Environmental effects of radiation
, Environmental effects of chemicals
, Tumor biology
, Laboratory animal science
Research keywords (4):
Radiation biology
, Radiation Oncology
, 環境リスク
, Stem cell kinetics
Research theme for competitive and other funds (16): - 2023 - 2027 Elucidation of the mechanism of radiation-related tumors focusing on the tumor microenvironment
- 2023 - 2027 Elucidation of the mechanism of radiation-related tumors focusing on the tumor microenvironment
- 2022 - 2027 幹細胞の可視化によるがん化プロセス解析マウスモデルを用いた放射線発がん機構の解明
- 2020 - 2023 発がんにおける組織幹細胞の細胞競合を可視化する解析系の確立とその応用
- 2020 - 2022 Development of mice model for elucidating the mechanism of healthy life expectancy extension
- 2019 - 2022 Development of radioprotectors that selectively protect normal tissues
- 2018 - 2021 Study of biological effects of ionizing radiation on mitochondria
- 2017 - 2021 A novel study on the mechanisms of low-dose radiation-induced aging and carcinogenesis
- 2017 - 2020 Mechanism of low dose(rate) radiation induced tumor development by using intestinal stem cell organoid system
- 2014 - 2018 Elucidation of the mechanisms of low dose, low dose-rate radiation induced mammary cancer through the interaction between mammary stem cells and their microenvironment
- 2013 - 2017 Molecular mechanism of radiation induced-leukemia using the animal model
- 2015 - 2016 Low-dose radiation risk assessment through investigating the mechanisms of low-dose radiation induced EMT
- 2013 - 2016 Development of mouse model susceptible to radiation-induced carcinogenesis at low dose and low dose rate and evaluation of radiation-induced cancer risk
- 2013 - 2015 Development of bio-dosimetry methods using radiation responsive urinary biomarker
- 2010 - 2012 The role of translesion DNA synthesis on radiation and chemical induced carcinogenesis
- 2010 - 2012 Development of a biological dosimeter to detect the DNA damage induced by low dose radiation and carcinogenic risk evaluation
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Papers (59): -
Sharmila Ghosh, Akinori Morita, Yuichi Nishiyama, Masahiro Sakaue, Ken Fujiwara, Daiki Morita, Yuichiro Sonoyama, Yuichi Higashi, Megumi Sasatani. Rectal Epithelial Stem Cell Kinetics in Acute Radiation Proctitis. International Journal of Molecular Sciences. 2024
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Guanyu Zhou, Tsutomu Shimura, Taiki Yoneima, Akiko Nagamachi, Akinori Kanai, Kazutaka Doi, Megumi Sasatani. Age-Dependent Differences in Radiation-Induced DNA Damage Responses in Intestinal Stem Cells. International Journal of Molecular Sciences. 2024
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Shimura, Tsutomu, Sunaga, Kenta, Yamazaki, Mayu, Honoka, Nara, Sasatani, Megumi, Kamiya, Kenji, Ushiyama, Akira. Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2024. 100. 4. 584-594
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Toyoshima-Sasatani, Megumi, Imura, Fumika, Hamatake, Yuko, Fukunaga, Akihiro, Negishi, Tomoe. Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila. GENES AND ENVIRONMENT. 2023. 45. 1
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Suzuki, Keiji, Imaoka, Tatsuhiko, Tomita, Masanori, Sasatani, Megumi, Doi, Kazutaka, Tanaka, Satoshi, Kai, Michiaki, Yamada, Yutaka, Kakinuma, Shizuko. Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver. JOURNAL OF RADIATION RESEARCH. 2023. 64. 2. 228-249
more... MISC (28): -
柳 亜希, 津山 尚宏, 柳井 祐佳理, 阿部 悠, 菅井 美咲, 太田 明伸, シバスンダラン・カルナン, 笹谷 めぐみ, 神谷 研二, 花村 一朗, et al. Bリンパ球由来iPS細胞からの骨髄腫細胞の起源となる異常Bリンパ球作製の試み(Attempt to make abnormal B lymphocytes as myeloma-initiating cells from B-iPSCs). 臨床血液. 2018. 59. 9. 1695-1695
- 清水なつみ, 清水なつみ, 河合秀彦, 笹谷めぐみ, 遠藤充浩, 稲葉俊哉, 神谷研二. 低線量放射線による着床前期胚の発生抑制メカニズム. 日本放射線影響学会大会抄録(Web). 2016. 59th. ROMBUNNO.O8-1 (WEB ONLY)-16
- 笹谷 めぐみ, 飯塚 大輔, 神谷 研二. 放射線発がん高感受性モデルマウスを用いた低線量放射線発がんリスク評価 (特集 第57回原子爆弾後障害研究会講演集). 長崎医学会雑誌. 2016. 91. 282-284
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清水 なつみ, 河合 秀彦, 笹谷 めぐみ, 遠藤 充浩, 稲葉 俊哉, 神谷 研二. The effect of low dose radiation on the development of pre-implantation embryos. 長崎医学会雑誌. 2016. 91. 0. 290-292
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The molecular mechanisms of the biological effect of low-dose radiation exposure on mammary glands. 2016. 69. 4. 302-304
more... Books (1): - 知っておきたい放射線の正しい知識
救急小冊子(広島県医師会) 2011
Education (3): - 2001 - 2005 Kyoto University Graduate School of Medicine Phisiology
- 1999 - 2001 Okayama University Graduate School of Natural Science and Technology Divisions of Pharmaceutical Science and Clinical Pharmaceutical Science
- 1995 - 1999 Okayama University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Science
Professional career (2): - Master of Pharmaceutical Science (Okayama University)
- Ph.D. (Kyoto University)
Work history (7): - 2018/04 - 現在 公益財団法人放射線影響研究所 来所研究員
- 2022/04 - 2023/03 Nagoya University
- 2018/02/01 - Hiroshima University Research Institute for Radiation Biology and Medicine Associate Professor
- 2007/04/01 - 2018/01/31 Hiroshima University Research Institute for Radiation Biology and Medicine Assistant Professor
- 2006/04/01 - 2007/03/31 Kyoto University Graduate School of Medicine Research Associate
- 2005/04 - 2006/03 Kyoto University Radiation Biology Center Part-time Researcher
- 2003/04/01 - 2005/03/31 JSPS Research Fellow, Japan Society for the Promotion of Science
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Committee career (13): - 2020/01 - 現在 日本環境変異原ゲノム学会 評議員
- 2018/09 - 現在 量子科学技術研究開発機構, 放射線リスク・防護研究基盤(PLANET)WG2 委員
- 2024/06 - 2026/06 日本放射線影響学会 学術評議員、理事、教育編集委員会委員長
- 2024/06 - 2026/05 日本原子力学会 「核融合炉の潜在リスクとその評価手法」研究専門委員会 委員
- 2024/04 - 2026/03 京都大学大学院生命科学研究科附属放射線生物研究センター 共同利用・共同研究専門委員会 委員
- 2024/02 - 2026/01 量子科学技術研究開発機構, 放射線リスク・防護研究基盤(PLANET)線量・線量率区分検討ワーキンググループ 委員
- 2018/06 - 2024/06 日本放射線影響学会 学術評議員
- 2019/09 - 2023/04 核融合科学研究所 運営会議共同研究委員会 委員
- 2020/04 - 2022/03 京都大学放射線生物研究センター 運営委員会 委員
- 2019/05 - 2021/03 京都大学放射線生物研究センター共同利用・共同研究専門委員会 委員
- 2018/04 - 2019/03 京都大学放射線生物研究センター 放射線連絡会議 幹事
- 2017/12 - 2018/03 放射線安全規制研究課題検討委員会 委員
- 2015/04 - 2017/03 京都大学放射線生物研究センター 将来計画専門委員会 委員
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Awards (3): - 2022/11/15 - 日本環境変異原ゲノム学会会長 日本環境変異原ゲノム学会(JEMS) 研究奨励賞 モデル生物を用いた放射線発がんの機構解明
- 2019 - 日本放射線影響学会 岩崎民子賞
- 2007 - 日本放射線影響学会奨励賞 日本放射線影響学会第50大会 奨励賞
Association Membership(s) (4):
The Japan Radiation Research Society
, The Molecular Biology Society of Japan
, The Japanese Environmental Mutagen Society (JEMS)
, Japanese Cancer Association
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