Horigome Chihiro

ホリゴメチヒロ | Horigome Chihiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Molecular biology

Research theme for competitive and other funds (8)：

2023 - 2025 出芽酵母を用いた革新的な寿命解析法の開発
2021 - 2024 細胞核内のアクチン繊維によるゲノム機能制御のメカニズム解明と応用展開
2021 - 2024 細胞核構造によるゲノム安定化と老化抑制の機構解明
2018 - 2021 Asymmetric inheritance of ribosomal DNA that governs cellular aging and rejuvenation
2019 - 2020 リボソームRNA遺伝子の核膜結合と不等分配に関する研究

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Papers (14)：

Mei Hattori, Chihiro Horigome, Théo Aspert, Gilles Charvin, Takehiko Kobayashi. Changed life course upon defective replication of ribosomal RNA genes. Genes & genetic systems. 2023. 97. 6. 285-295
Saho Kitagawa, Masayuki Kusakabe, Daisuke Takahashi, Takumi Narimiya, Yu Nakabayashi, Masayuki Seki, Chihiro Horigome, Masahiko Harata. Analysis of the molecular evolution of histone variant H2A.Z using a linker-mediated complex strategy and yeast genetic complementation. Bioscience, Biotechnology, and Biochemistry. 2021. 86. 1. 104-108
Chihiro Horigome, Eri Unozawa, Takamasa Ooki, Takehiko Kobayashi. Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage. PLoS genetics. 2019. 15. 4. e1008103
Isabella Marcomini, Kenji Shimada, Neda Delgoshaie, Io Yamamoto, Andrew Seeber, Anais Cheblal, Chihiro Horigome, Ulrike Naumann, Susan M Gasser. Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation. Cell reports. 2018. 24. 10. 2614-2628
Chihiro Horigome, Denise E Bustard, Isabella Marcomini, Neda Delgoshaie, Monika Tsai-Pflugfelder, Jennifer A Cobb, Susan M Gasser. PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes & development. 2016. 30. 8. 931-45

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MISC (4)：

Chihiro Horigome, Takehiko Kobayashi. Rejuvenation of ribosomal RNA gene repeats at the nuclear pore. CURRENT GENETICS. 2020. 66. 1. 7-13
Chihiro Horigome, Susan M. Gasser. SUMO wrestles breaks to the nuclear ring's edge. CELL CYCLE. 2016. 15. 22. 3011-3013
Chihiro Horigome, Vincent Dion, Andrew Seeber, Lutz R Gehlen, Susan M Gasser. Visualizing the spatiotemporal dynamics of DNA damage in budding yeast. Methods in molecular biology (Clifton, N.J.). 2015. 1292. 77-96
Chihiro Horigome, Keiko Mizuta. Ribosome biogenesis factors working with a nuclear envelope SUN domain protein New players in the solar system. NUCLEUS. 2012. 3. 1. 22-28

Lectures and oral presentations (23)：

Visualizing homology search during DNA double-strand break repair in yeast
(2024)
クライオX線タイコグラフィの開発と生体試料への応用
(第37回日本放射光学会年会・放射光科学合同シンポジウム 2024)
出芽酵母の核膜におけるリボソーム RNA 遺伝子の安定維持機構の解明
(日本農芸化学会東北支部第158回大会 2023)
細胞核内のアクチン繊維がFUSタンパク質の液-液相分離に与える影響の解析
(日本農芸化学会東北支部第158回大会 2023)
Visualizing homology search during DNA double strand break repair
(2023)

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Education (3)：

Professional career (1)：

Work history (10)：

2023/07 - 現在 RIKEN
2023/04 - 現在 Tohoku University Graduate School of Agricultural Science Agricultural Chemistry Associate Professor
2021/07 - 2024/06 Tohoku University
2020/10 - 2023/03 Tohoku University Graduate School of Agricultural Science Division of Life Science Assistant Professor
2018/04 - 2020/09 The University of Tokyo Institute for Quantitative Biosciences Research Associate

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Committee career (1)：

Awards (2)：

2023/09 - The Genetics Society of Japan Genes & Genetic Systems, GGS PRIZE 2023 Changed life course upon defective replication of ribosomal RNA genes
2023/09 - 酵母遺伝学フォーラム酵母遺伝学フォーラム第56回研究報告会会長賞相同組換え修復におけるホモロジー・サーチの動態解析

Association Membership(s) (3)：

日本農芸化学会 , 酵母遺伝学フォーラム , 日本分子生物学会

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