
	Chemical structure search How to Search	Import MOLfile format is only available (V3000 format is not available) Exact match Substructure search Superstructure search Substructure or superstructure search Similarity search

Rchr

J-GLOBAL ID：201801016995893012 Update date: Oct. 10, 2024

MIKIO TANABE

タナベミキオ | MIKIO TANABE

Affiliation and department：

Research field (1)： Structural biochemistry

Research keywords (6)：薬剤耐性 , トランスポーター , 細菌学 , 膜タンパク質 , 感染症 , 構造生物学

Research theme for competitive and other funds (6)：

2024 - 2028 Deorphanization of MFS-Type Multidrug Efflux Transporters: Inhibition of Drug Efflux and Physiological function
2021 - 2024 Structural analyses of PMP22 and MPZ to elucidate the molecular mechanism of Charcot-Marie-Tooth disease
2019 - 2023 MFS型多剤排出輸送体の多剤認識と輸送機構の解明
2019 - 2022 MAドメインとカルジオリピンとの結合を基軸とした抗エイズ薬の創製
2017 - 2021 Creation of a multicolor bioluminescence platform for assaying bioactive small molecules

Show all

Papers (34)：

Takahiro Kosugi, Mikio Tanabe, Nobuyasu Koga. De novo design of ATPase based on the blueprint optimized for harboring the P-loop motif. 2024
Masayoshi Sakakura, Mikio Tanabe, Masaki Mori, Hideo Takahashi, Kazuhiro Mio. Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero. Structure (London, England : 1993). 2023
Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino, Nobuyasu Koga. Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites. Nature chemistry. 2023
Sung-Bae Kim, Rika Fujii, Simon Miller, Mikio Tanabe. Molecular Tension Probe for In Vitro Bioassays. Methods in molecular biology (Clifton, N.J.). 2022. 2524. 91-103
Annika Bartsch, Callum M Ives, Christof Kattner, Florian Pein, Manuel Diehn, Mikio Tanabe, Axel Munk, Ulrich Zachariae, Claudia Steinem, Salomé Llabrés. An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding. Biochimica et biophysica acta. Biomembranes. 2021. 1863. 6. 183601-183601

MISC (2)：

Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino, Nobuyasu Koga. De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function. BioRxiv. 2020
MFS型多剤排出トランスポーターMdfAの薬剤輸送に伴う構造変化のメカニズム. 2020. 56. 6. 509-513

Lectures and oral presentations (7)：

Structural and molecular dynamical approaches to understand mysterious mechanistic aspects of a H+/multidrug transporter
(HALOmem International Meeting - Membrane Protein & Dynamics - 2019)
Structural and Molecular Dynamical Approaches to understand MFS-type Multidrug Resistance Transporters
(Gordon Research Conference - Multidrug efflux systems 2019)
Structural biology research center in KEK/high energy accelerator research organization
(Protein Structure determination in Industry (PSDI) 2018. 2018)
多剤排出トランスポーターの薬剤物質排出メカニズム解明に向けての構造生学的アプローチ
(第90回日本薬理学会年会 2017)
MFS型多剤排出トランスポーターMdfAの薬剤物質排出に伴う構造変化の解明
(第90回日本細菌学会総会 2017)

Education (3)：

2002 - 2006 Imperial College London Division of Molecular Biosciences & Division of Cell and Molecular Biology.
2000 - 2002 大阪大学工学研究科応用生物学専攻 M.Eng. 産業科学研究所
1999 - 2000 Osaka University School of Engineering

Professional career (1)：

Work history (4)：

2024/10 - 現在 High Energy Accelerator Research Organization Institute of Materials Structure Science Structural Biology Research Center
2015 - 現在 High Energy Accelerator Research Organization
2009 - 2015 Martin-Luther-University Halle-Wittenberg
2006 - 2009 Vanderbilt University Medical Center Department of Pharmacology

Committee career (1)：

Awards (2)：

Association Membership(s) (3)：

タンパク質科学会 , THE JAPANESE PHARMACOLOGICAL SOCIETY , JAPANESE SOCIETY FOR BACTERIOLOGY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.


	Free word	※Add the following synonyms, you can increase the number of hits.




		～