Rchr
J-GLOBAL ID：201801016995893012   Update date: Feb. 01, 2024

MIKIO TANABE

タナベ ミキオ | MIKIO TANABE
Affiliation and department：
大学共同利用機関法人高エネルギー加速器研究機構 物質構造科学研究所、構造生物学研究センター

About 大学共同利用機関法人高エネルギー加速器研究機構 物質構造科学研究所、構造生物学研究センター


Job title： 特任准教授
Research field  (1)： Structural biochemistry
Research keywords  (6)： 薬剤耐性 ,  トランスポーター ,  細菌学 ,  膜タンパク質 ,  感染症 ,  構造生物学
Research theme for competitive and other funds  (5)：
  • 2021 - 2024 Structural analyses of PMP22 and MPZ to elucidate the molecular mechanism of Charcot-Marie-Tooth disease
  • 2019 - 2023 MFS型多剤排出輸送体の多剤認識と輸送機構の解明
  • 2019 - 2022 MAドメインとカルジオリピンとの結合を基軸とした抗エイズ薬の創製
  • 2017 - 2021 Creation of a multicolor bioluminescence platform for assaying bioactive small molecules
  • 2016 - 2018 Investigation of outer membrane protein recognition mechniams by human pathgen recognition receptors
Papers (33)：
  • Masayoshi Sakakura, Mikio Tanabe, Masaki Mori, Hideo Takahashi, Kazuhiro Mio. Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero. Structure (London, England : 1993). 2023
  • Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino, Nobuyasu Koga. Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites. Nature chemistry. 2023
  • Sung-Bae Kim, Rika Fujii, Simon Miller, Mikio Tanabe. Molecular Tension Probe for In Vitro Bioassays. Methods in molecular biology (Clifton, N.J.). 2022. 2524. 91-103
  • Annika Bartsch, Callum M Ives, Christof Kattner, Florian Pein, Manuel Diehn, Mikio Tanabe, Axel Munk, Ulrich Zachariae, Claudia Steinem, Salomé Llabrés. An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding. Biochimica et biophysica acta. Biomembranes. 2021. 1863. 6. 183601-183601
  • David Drew, Rachel A North, Kumar Nagarathinam, Mikio Tanabe. Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS). Chemical reviews. 2021. 121. 9. 5289-5335
ｍore...
MISC (2)：
Lectures and oral presentations  (7)：
  • Structural and molecular dynamical approaches to understand mysterious mechanistic aspects of a H+/multidrug transporter
    (HALOmem International Meeting - Membrane Protein & Dynamics - 2019)
  • Structural and Molecular Dynamical Approaches to understand MFS-type Multidrug Resistance Transporters
    (Gordon Research Conference - Multidrug efflux systems 2019)
  • Structural biology research center in KEK/high energy accelerator research organization
    (Protein Structure determination in Industry (PSDI) 2018. 2018)
  • 多剤排出トランスポーターの薬剤物質排出メカニズム解明に向けての構造生学的アプローチ
    (第90回日本薬理学会年会 2017)
  • MFS型多剤排出トランスポーターMdfAの薬剤物質排出に伴う構造変化の解明
    (第90回日本細菌学会総会 2017)
ｍore...
Education (3)：
  • 2002 - 2006 Imperial College London Division of Molecular Biosciences & Division of Cell and Molecular Biology.
  • 2000 - 2002 大阪大学 工学研究科応用生物学専攻 M.Eng. 産業科学研究所
  • 1999 - 2000 Osaka University School of Engineering
Professional career (1)：
  • Ph.D. (Imperial College London)
Work history (3)：
  • 2015 - 現在 High Energy Accelerator Research Organization
  • 2009 - 2015 Martin-Luther-University Halle-Wittenberg
  • 2006 - 2009 Vanderbilt University Medical Center Department of Pharmacology
Committee career (1)：
  • 2022 - Frontiers in Biophysics Editorial Board
Awards (2)：
  • 2013 - Hugo-Junkers-Prize (ドイツ)
  • 2006 - 上原記念ポストドクトラルフェローシップ
Association Membership(s) (3)：
タンパク質科学会 ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  JAPANESE SOCIETY FOR BACTERIOLOGY
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