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J-GLOBAL ID：201801018093701822 Update date: Apr. 07, 2025

Saki Noguchi

ノグチサキ | Saki Noguchi

Affiliation and department：
Job title： Research Associate/Assistant Professor/Instructor

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (11)：

2023 - 2026 Analysis of the regulation of placental barrier factors for prediction of placental endocrine disruption
2022 - 2024 有機酸取り込みトランスポーターを標的とした腎不全予防法の提案
2020 - 2022 Regulation of pharmacokinetics during pregnancy by placental exosomes
2020 - 2022 Developing the kinetic approach to treat the metabolic disorder from the bilateral side of proximal tubules
2020 - 2022 尿細管の両面動態にアプローチする先天性代謝疾患治療法の開拓

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Papers (22)：

Tomohiro Nishimura, Ryo Mizokami, Mayuko Yamanaka, Masaya Takahashi, Yuko Yoshida, Yuya Ogawa, Saki Noguchi, Masatoshi Tomi. Fetal ezrin expression affects macrophages and regulatory T cells in mouse placental decidua. Biochemical and Biophysical Research Communications. 2024. in press
Naomi Fukazawa, Tomohiro Nishimura, Keisuke Orii, Saki Noguchi, Masatoshi Tomi. Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1. Pharmaceutical research. 2024. 41. 5. 849-861
Tomohiro Nishimura, Hikari Araki, Kei Higuchi, Saki Noguchi, Kei Saito, Kanako Hara, Haruya Yagishita, Risa Akashi, Sakiko Obata, Masatoshi Tomi. Involvement of GAT2/Slc6a13 in hypotaurine uptake at fetal-facing plasma membrane of syncytiotrophoblasts at mid-to-late gestation in rats and mice. Placenta. 2024. 147. 59-67
Nishimura T., Ishii M., Tanaka H., Noguchi S., Ikeda T., Tomi M. Breast Cancer Resistance Protein Limits Fetal Transfer of Tadalafil in Mice. Journal of Pharmaceutical Sciences. 2023
Tomoya Akashi, Saki Noguchi, Yu Takahashi, Tomohiro Nishimura, Masatoshi Tomi. L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids. Journal of Pharmaceutical Sciences. 2023. 112. 4. 1137-1144

MISC (5)：

西村友宏, 石井まり, 野口幸希, 田中博明, 池田智明, 登美斉俊. タダラフィルのマウス胎仔移行におけるBCRPの関与. 日本薬学会年会要旨集. 2022. 142年会. 26C-pm04
西村友宏, 野口幸希. 【「今さら聞けない」をスッキリ解消する妊娠・授乳と薬】[妊娠と薬]妊娠による生理学的変化と薬物動態. 薬事. 2020. 62. 4. 717-727
高橋優, 西村友宏, 樋口慧, 野口幸希, 手賀悠真, 黒澤俊樹, 出口芳春, 登美斉俊. 血液脳関門における中性アミノ酸トランスポーターLAT1を介したpregabalin輸送. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2018. 40th
Masatoshi Tomi, Saki Noguchi, Ayasa Fujibayashi, Tetsuo Maruyama, Emi Nakashima, Tomohiro Nishimura. ROLE OF ORGANIC ANION TRANSPORTER 4 ON THE TRANSPORT OF OLMESARTAN ACROSS THE BASAL PLASMA MEMBRANE OF HUMAN PLACENTAL SYNCYTIOTROPHOBLAST. PLACENTA. 2016. 45. 133-133
Saki Noguchi, Tomohiro Nishimura, Tetsuo Maruyama, Masatoshi Tomi, Emi Nakashima. OAT4-MEDIATED TRANSPORT OF OLMESARTAN AT THE BASAL PLASMA MEMBRANE OF THE HUMAN PLACENTAL BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 296-296

Lectures and oral presentations (160)：

自然流産モデルマウス胎盤におけるpregnancy-specific glycoproteinファミリーのタンパク質定量
(第39回日本生殖免疫学会学術集会 2024)
ヒト胎盤灌流からの胎児薬物暴露量予測精度の向上
(第4回妊娠と薬情報研究会学術集会 2024)
ヒト栄養膜幹細胞から分化させた合胞体栄養膜細胞におけるpropionic acid輸送機構
(第32回日本胎盤学会学術集会 2024)
胎盤関門におけるMATE1の発現量種差と薬物の胎児移行性
(第45回生体膜と薬物の相互作用シンポジウム 2024)
胎仔胎盤系のOCTN1がエルゴチオネインの胎仔移行と胎仔成長に与える影響
(第44回日本妊娠高血圧学会学術集会 2024)

Professional career (1)：

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