Saki Noguchi

ノグチサキ | Saki Noguchi

Affiliation and department：
Job title： Research Associate/Assistant Professor/Instructor

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (11)：

2023 - 2026 Analysis of the regulation of placental barrier factors for prediction of placental endocrine disruption
2022 - 2024 有機酸取り込みトランスポーターを標的とした腎不全予防法の提案
2020 - 2022 Regulation of pharmacokinetics during pregnancy by placental exosomes
2020 - 2022 Developing the kinetic approach to treat the metabolic disorder from the bilateral side of proximal tubules
2020 - 2022 尿細管の両面動態にアプローチする先天性代謝疾患治療法の開拓

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Papers (20)：

Tomohiro Nishimura, Hikari Araki, Kei Higuchi, Saki Noguchi, Kei Saito, Kanako Hara, Haruya Yagishita, Risa Akashi, Sakiko Obata, Masatoshi Tomi. Involvement of GAT2/Slc6a13 in hypotaurine uptake at fetal-facing plasma membrane of syncytiotrophoblasts at mid-to-late gestation in rats and mice. Placenta. 2024. 147. 59-67
Nishimura T, Ishii M, Tanaka H, Noguchi S, Ikeda T, Tomi M. Breast Cancer Resistance Protein Limits Fetal Transfer of Tadalafil in Mice. Journal of Pharmaceutical Sciences. 2023
Tomoya Akashi, Saki Noguchi, Yu Takahashi, Tomohiro Nishimura, Masatoshi Tomi. L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids. Journal of Pharmaceutical Sciences. 2023. 112. 4. 1137-1144
Fujita A, Noguchi S, Hamada R, Shimada T, Katakura S, Maruyama T, Sai Y, Nishimura T, Tomi M. Quantitative comparison of breast cancer resistance protein (BCRP/ABCG2) expression and function between blood-brain barrier and placental barrier in mice at different gestational ages. Frontiers in Drug Delivery. 2022
Kurosawa K, Noguchi S, Nishimura T, Tomi M, Chiba K. Transplacental Pharmacokinetic Model of Digoxin Based on Ex Vivo Human Placental Perfusion Study. Drug metabolism and disposition: the biological fate of chemicals. 2022. 50. 3. 287-298

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MISC (4)：

西村友宏, 野口幸希. 【「今さら聞けない」をスッキリ解消する妊娠・授乳と薬】[妊娠と薬]妊娠による生理学的変化と薬物動態. 薬事. 2020. 62. 4. 717-727
高橋優, 西村友宏, 樋口慧, 野口幸希, 手賀悠真, 黒澤俊樹, 出口芳春, 登美斉俊. 血液脳関門における中性アミノ酸トランスポーターLAT1を介したpregabalin輸送. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2018. 40th
Masatoshi Tomi, Saki Noguchi, Ayasa Fujibayashi, Tetsuo Maruyama, Emi Nakashima, Tomohiro Nishimura. ROLE OF ORGANIC ANION TRANSPORTER 4 ON THE TRANSPORT OF OLMESARTAN ACROSS THE BASAL PLASMA MEMBRANE OF HUMAN PLACENTAL SYNCYTIOTROPHOBLAST. PLACENTA. 2016. 45. 133-133
Saki Noguchi, Tomohiro Nishimura, Tetsuo Maruyama, Masatoshi Tomi, Emi Nakashima. OAT4-MEDIATED TRANSPORT OF OLMESARTAN AT THE BASAL PLASMA MEMBRANE OF THE HUMAN PLACENTAL BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 296-296

Lectures and oral presentations (140)：

OAT4介在輸送がアンジオテンシンII受容体拮抗薬(ARB)の経細胞透過に果たす役割
(日本薬学会第144年会)
Ezrin遺伝子欠損に伴う胎仔発育不全と胎盤免疫寛容の機能低下の関連解析
(日本薬学会第144年会)
Enhanced invasion of extravascular trophoblast cells by human vascular endothelial cells and its effect on gene expression
(Asian Federation for Pharmaceutical Sciences 2023)
Fetal transfer of tadalafil, a PDE5 inhibitor, is limited by BCRP at murine placental barrier
(Asian Federation for Pharmaceutical Sciences 2023)
Transport mechanism of propionic acid in human choriocarcinoma JEG-3 cells
(Asian Federation for Pharmaceutical Sciences 2023)

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Professional career (1)：

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