Research field (1)：
Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (13)：
2024 - 2027 Elucidation of function of selenium binding proteins in inter cellular selenium transport and metabolism
2022 - 2024 Investigation into the selenium metabolism by synchrotron radiation X-ray analysis
2021 - 2022 細胞内セレン結合性タンパク質の機能解析
2021 - 2022 脳内α-シヌクレイン凝集体を標的とした分子プローブ及び凝集阻害剤 の開発
2019 - 2022 Elucidation of the function of selenium binding protein in selenium metabolic pathway in heart
2020 - 2021 脳内α-シヌクレイン凝集体を標的とした分子プローブ及び凝集阻害剤の開発
2018 - 2021 Development of nanobody molecular probes for early diagnosis of pancreatic cancers
2019 - 2020 脳内α-シヌクレイン凝集体を標的とした分子プローブ及び凝集阻害剤の 開発
2016 - 2019 Development of a unified producing system for various 68Ga-radiopharmaceuticals based on the characteristics of novel 68Ge/68Ga generator.
2016 - 2019 Development of multimodal imaging probes targeting survivin.
2016 - 2019 Investigation into the selenium transport and specific retention mechanism in brain
2015 - 2018 Development of fusion peptides of beta-hairpin peptides and survivin binding molecules as cancer-specific internal radiotherapeutic agents
2016 - 2017 魚介類由来必須微量栄養素セレンによるAβ蓄積抑制効果の検討
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Papers (36)：
Takeshi Fuchigami, Tomoe Nakayama, Yusuke Miyanari, Iori Nozaki, Natsumi Ishikawa, Ayako Tagawa, Sakura Yoshida, Masayuki Munekane, Morio Nakayama, Kazuma Ogawa. Peptide-Based Turn-On Fluorescent Probes for Highly Specific Detection of Survivin Protein in the Cancer Cells. Chemical and Biomedical Imaging. 2024
Yoshida S, Mori R, Hayashi R, Fuchigami T, Toriba A, Nakayama M, Haratake M. Bioavailability of selenium from selenotrisulfides in primary cultured neuronal cells. Metallomics Research. 2022. 2. 3. MR202207
Iori Nozaki, Natsumi Ishikawa, Yusuke Miyanari, Kazuma Ogawa, Ayako Tagawa, Sakura Yoshida, Masayuki Munekane, Kenji Mishiro, Akira Toriba, Morio Nakayama, et al. Borealin-Derived Peptides as Survivin-Targeting Cancer Imaging and Therapeutic Agents. Bioconjugate chemistry. 2022. 33. 11. 2149-2160
Shota Yoshida, Hongyan Zhang, Ryuji Takahashi, Sakura Yoshida, Yumi Abiko, Akira Toriba. Identification and removal of aflatoxin coprecipitates derived from plant samples on immunoaffinity chromatographic purification. Journal of chromatography. A. 2022. 1678. 463382-463382
Mari Nakaie, Fumihiro Katayama, Takehiro Nakagaki, Sakura Yoshida, Masao Kawasaki, Kodai Nishi, Kazuma Ogawa, Akira Toriba, Noriyuki Nishida, Morio Nakayama, et al. Synthesis and Biological Evaluation of Novel 2-(Benzofuran-2-yl)-chromone Derivatives for In Vivo Imaging of Prion Deposits in the Brain. ACS infectious diseases. 2022. 8. 9. 1869-1882
吉田さくら, 山本明典, 増本博司, 淵上剛志, 鳥羽陽, 原武衛, 中山守雄. Exploration of rat brain proteins that can react with metabolic intermediate of selenious acid. 衛生薬学・環境トキシコロジー講演要旨集. 2021. 2021
吉田さくら, 山本明典, 増本博司, 堀恵里子, 浦東子, 淵上剛志, 原武衛, 中山守雄. Identification of protein reactive with reduced metabolite of selenious acid in rat brain. 衛生薬学・環境トキシコロジー講演要旨集. 2020. 2020
