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J-GLOBAL ID：201801018384542438   Update date: Jan. 21, 2025

Shimon Otake

オオタケ シモン | Shimon Otake
Affiliation and department：
Nihon University School of Medicine Department of Medicine

About Nihon University School of Medicine Department of Medicine


Job title： Associate Professor
Research field  (3)： Other ,  Hematology and oncology ,  Other
Research theme for competitive and other funds  (12)：
  • 2024 - 2025 Elucidation of the roles of platelet in hepatic sinusoidal obstruction syndrome and basic studies for clinical application
  • 2024 - 2025 抗CD20抗体治療後の腸内細菌叢に対するプロバイオティクスの影響分析
  • 2021 - 2024 肝類洞閉塞症候群における血小板活性化受容体CLEC-2の役割解明
  • 2023 - 2024 肝類洞閉塞症候群における,血小板活性化受容体 CLEC-2 の役割解明
  • 2020 - 2023 血小板活性化受容体CLEC-2を標的とした抗体医薬の開発とその薬理作用の解明
Show all
Papers (22)：
  • Hiromichi Takahashi, Shun Ito, Yoko Nakanishi, Katsuhiro Miura, Haruna Nishimaki, Masaru Nakagawa, Shimon Otake, Takashi Hamada, Takashi Koike, Kazuhide Iizuka, et al. Topological importance of CD8+ T-cell enrichment in the tumor microenvironment of classic Hodgkin lymphoma. Annals of hematology. 2025
  • Katsuhiro Miura, Haruna Nishimaki-Watanabe, Hiromichi Takahashi, Masaru Nakagawa, Shimon Otake, Takashi Hamada, Takashi Koike, Kazuhide Iizuka, Yuuichi Takeuchi, Kazuya Kurihara, et al. TAFRO Syndrome: Guidance for Managing Patients Presenting Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly. Biomedicines. 2024. 12. 6
  • Takashi Hamada, Hiromichi Takahashi, Masaru Nakagawa, Hironao Nukariya, Shun Ito, Toshihide Endo, Kazuya Kurihara, Takashi Koike, Kazuhide Iizuka, Shimon Ohtake, et al. Pulmonary Veno-Occlusive Disease after Autologous Stem Cell Transplantation. Case reports in oncology. 2023. 16. 1. 338-346
  • Katsuhiro Miura, Hiromichi Takahashi, Masaru Nakagawa, Takashi Hamada, Yoshihito Uchino, Kazuhide Iizuka, Shimon Ohtake, Noriyoshi Iriyama, Yoshihiro Hatta, Hideki Nakamura. Ideal dose intensity of R-CHOP in diffuse large B-cell lymphoma. Expert review of anticancer therapy. 2022. 22. 6. 583-595
  • 大石 沙織, 築地 長治, 大竹 志門, 大石 直輝, 佐々木 知幸, 白井 俊光, 吉川 佑莉, 高野 勝弘, 新森 英之, 犬飼 岳史, et al. 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割. 日本血栓止血学会誌. 2021. 32. 2. 209-209
ｍore...
MISC (2)：
  • Hiromichi Takahashi, Sumiko Kobayashi, Katsuhiro Miura, Daisuke Kurita, Yoshihiro Hatta, Masahiko Sugitani, Shimon Otake, Masaru Nakagawa, Masashi Sakagami, Yoshihito Uchino, et al. Clinical Significance of Co-Expression of MYC and BCL2 Protein in Advanced Diffuse Large B-Cell Lymphoma Treated with a Dose-Intensified Immunochemotherapy. BLOOD. 2015. 126. 23
  • Katsuhiro Miura, Satomi Kiso, Masaru Nakagawa, Hiromichi Takahashi, Yoshito Uchino, Hitomi Kodaira, Noriyoshi Iriyama, Masashi Sakagami, Shimon Ohtake, Sumiko Kobayashi, et al. Clinical Significance of Arbekacin Sulfate for High-Risk Infections Among Patients with Hematological Malignancies. BLOOD. 2014. 124. 21
Lectures and oral presentations  (11)：
  • Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis
    (ISTH2019 2019)
  • Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury
    (ISTH2019 2019)
  • 血小板・巨核球上のC型レクチン様受容体(CLEC-2)が、赤血球造血に及ぼす役割
    (第41回日本血栓止血学会学術集会 2019)
  • ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与
    (第41回日本血栓止血学会学術集会 2019)
  • Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesis
    (The 80th Annual Meeting of the Japanese Society of Hematology 2018)
ｍore...
Education (2)：
  • 2016 - 2020 University of Yamanashi 博士課程
  • 2005 - 2011 Nihon University 医学部
Professional career (1)：
  • M.D., Ph.D. (University of Yamanashi)
Work history (5)：
  • 2022/11 - 現在 Nihon University School of Medicine Department of Medicine Associate Professor
  • 2017/12/16 - 山梨大学 臨床検査医学講座 助教
  • 2016/04 - 山梨大学医学部附属病院 検査部 医員
  • 2013/04 - 2016/03 日本大学医学部附属板橋病院 血液膠原病内科 後期研修医
  • 2011/04 - 2013/03 国立病院機構 西埼玉中央病院 臨床研修医
Awards (3)：
  • 2022/06 - 日本血栓止血学会 学術奨励賞
  • 2019/07 - ISTH2019 Early Career Award
  • 2019/06 - 第41回日本血栓止血学会 一般演題優秀賞
Association Membership(s) (6)：
日本造血細胞移植学会 ,  日本輸血・細胞治療学会 ,  日本血栓止血学会 ,  日本内科学会 ,  日本血液学会 ,  International Society on Thrombosis and Haemostasis
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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