Shimon Otake

オオタケシモン | Shimon Otake

Affiliation and department：
Job title： Associate Professor

Research field (3)： Other , Hematology and oncology , Other

Research theme for competitive and other funds (12)：

2024 - 2025 Elucidation of the roles of platelet in hepatic sinusoidal obstruction syndrome and basic studies for clinical application
2024 - 2025 抗CD20抗体治療後の腸内細菌叢に対するプロバイオティクスの影響分析
2021 - 2024 肝類洞閉塞症候群における血小板活性化受容体CLEC-2の役割解明
2023 - 2024 肝類洞閉塞症候群における,血小板活性化受容体 CLEC-2 の役割解明
2020 - 2023 血小板活性化受容体CLEC-2を標的とした抗体医薬の開発とその薬理作用の解明

Show all

Papers (20)：

Takashi Hamada, Hiromichi Takahashi, Masaru Nakagawa, Hironao Nukariya, Shun Ito, Toshihide Endo, Kazuya Kurihara, Takashi Koike, Kazuhide Iizuka, Shimon Ohtake, et al. Pulmonary Veno-Occlusive Disease after Autologous Stem Cell Transplantation. Case reports in oncology. 2023. 16. 1. 338-346
Katsuhiro Miura, Hiromichi Takahashi, Masaru Nakagawa, Takashi Hamada, Yoshihito Uchino, Kazuhide Iizuka, Shimon Ohtake, Noriyoshi Iriyama, Yoshihiro Hatta, Hideki Nakamura. Ideal dose intensity of R-CHOP in diffuse large B-cell lymphoma. Expert review of anticancer therapy. 2022. 22. 6. 583-595
大石沙織, 築地長治, 大竹志門, 大石直輝, 佐々木知幸, 白井俊光, 吉川佑莉, 高野勝弘, 新森英之, 犬飼岳史, et al. 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割. 日本血栓止血学会誌. 2021. 32. 2. 209-209
Saori Oishi, Nagaharu Tsukiji, Shimon Otake, Naoki Oishi, Tomoyuki Sasaki, Toshiaki Shirai, Yuri Yoshikawa, Katsuhiro Takano, Hideyuki Shinmori, Takeshi Inukai, et al. Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ. Blood Advances. 2021. 5. 7. 2017-2026
大竹志門, 大石沙織, 築地長治, 大石直輝, 佐々木知幸, 白井俊光, 高野勝弘, 近藤哲夫, 井上克枝. ヘミンはCLEC-2とGPVI/FcRγを介して血小板を活性化し、横紋筋融解による急性腎障害を悪化させる. 日本透析医会雑誌. 2021. 36. 1. 141-145

ｍore...

MISC (2)：

Hiromichi Takahashi, Sumiko Kobayashi, Katsuhiro Miura, Daisuke Kurita, Yoshihiro Hatta, Masahiko Sugitani, Shimon Otake, Masaru Nakagawa, Masashi Sakagami, Yoshihito Uchino, et al. Clinical Significance of Co-Expression of MYC and BCL2 Protein in Advanced Diffuse Large B-Cell Lymphoma Treated with a Dose-Intensified Immunochemotherapy. BLOOD. 2015. 126. 23
Katsuhiro Miura, Satomi Kiso, Masaru Nakagawa, Hiromichi Takahashi, Yoshito Uchino, Hitomi Kodaira, Noriyoshi Iriyama, Masashi Sakagami, Shimon Ohtake, Sumiko Kobayashi, et al. Clinical Significance of Arbekacin Sulfate for High-Risk Infections Among Patients with Hematological Malignancies. BLOOD. 2014. 124. 21

Lectures and oral presentations (11)：

Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis
(ISTH2019 2019)
Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury
(ISTH2019 2019)
血小板・巨核球上のC型レクチン様受容体(CLEC-2)が、赤血球造血に及ぼす役割
(第41回日本血栓止血学会学術集会 2019)
ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与
(第41回日本血栓止血学会学術集会 2019)
Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesis
(The 80th Annual Meeting of the Japanese Society of Hematology 2018)

ｍore...

Education (2)：

Professional career (1)：

Work history (5)：

2022/11 - 現在 Nihon University School of Medicine Department of Medicine Associate Professor
2017/12/16 - 山梨大学臨床検査医学講座助教
2016/04 - 山梨大学医学部附属病院検査部医員
2013/04 - 2016/03 日本大学医学部附属板橋病院血液膠原病内科後期研修医
2011/04 - 2013/03 国立病院機構西埼玉中央病院臨床研修医

Awards (3)：

Association Membership(s) (6)：

日本造血細胞移植学会 , 日本輸血・細胞治療学会 , 日本血栓止血学会 , 日本内科学会 , 日本血液学会 , International Society on Thrombosis and Haemostasis

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page