Research field (4):
Fetal medicine/Pediatrics
, Cardiology
, Genetics
, Developmental biology
Research theme for competitive and other funds (18):
2024 - 2027 Dosage regimen for receptor antagonists based on longitudinal mathematical model considering patients' growth and disease risk
2022 - 2025 MYH7の多様性に着目した心筋緻密化障害の病態の解明
2022 - 2025 フォンタン術後のタンパク漏出性胃腸症の早期発見と治療に向けた基盤の構築
2021 - 2024 Comprehensive genetic and morphological analysis for sudden cardiac death autopsy cases
2021 - 2024 Mechanisms for the pharmacokinetic variability in patients with right-sided heart failure: A longitudinal data analysis for optimization of the dosage regimen.
2021 - 2024 孤立性右室低形成の全国実態調査と遺伝学的病態解明
2018 - 2023 単球・マクロファージの川崎病への関与:ncRNAを視点とした発症機序の解明
2019 - 2022 Pathophysiology of left ventricular noncompaction: focus on the importance of the downstream pathway of the transcription factor TBX5
2018 - 2022 A longitudinal study on the pharmacokinetics considering individual differences of developmental change and optimization of long-term drug administration
2016 - 2019 Clinical characteristics and prognosis of fetal left ventricular noncompaction in Japan
2015 - 2018 Mechanisms of the pharmacokinetic variability and optimization of drug therapy in children with congenital heart disease
2015 - 2018 Genetic analysis and pathological role in ventricular noncompaction associated with fatal arrhythmia
2015 - 2018 Clarification of vasculitis in Kawasaki disease; focusing on the endothelial microparticles
2014 - 2017 Establishment of novel diagnosis and analysis of pathogenesis of herediatry lymphoproliferative disorders
2013 - 2016 Uncovering the mechanism of LVNC; functional study of in vitro study using with iPSCs from the patient's blood sample
2012 - 2015 A simple method to evaluate pharmacokinetics in children with a reduced blood sampling and optimization of dosage of cardiovascular drugs.
2008 - 2010 Impact of SCN5A gene mutations in prognosis of left ventricular noncompaction
2008 - 2009 Analysis of Pathogen Associated Molecular Pattern(PAMP) in the vascular endothelial cell during acute Kawasaki Disease
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Papers (115):
Keiichi Hirono, Yukiko Hata, Shojiro Ichimata, Naoki Nishida, Teruhiko Imamura, Yoshihiro Asano, Yuki Kuramoto, Kaori Tsuboi, Shinya Takarada, Mako Okabe, et al. Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts. Scientific reports. 2024. 14. 1. 30469-30469
Keiichi Hirono, Yukiko Hata, Teruhiko Imamura, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Shojiro Ichimata, et al. Determination of Genotype and Phenotypes in Pediatric Patients With Biventricular Noncompaction. Journal of the American Heart Association. 2024. 13. 21. e035614
Shunji Seki, Makoto Nishibatake, Keiichi Hirono, Kentaro Ueno. Rare pediatric case of two episodes of fulminant myocarditis and cardiac dysfunction after viral infection. Journal of cardiology cases. 2024. 30. 2. 39-42
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Keiichi Hirono, Naoki Nishida. Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study. International Journal of Molecular Sciences. 2024
Tomohide Sakai, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka W Ozawa, Yukiko Hata, Shojiro Ichimata, Naoki Nishida, et al. Tachycardia-Induced Cardiomyopathy in an Infant with Atrial Flutter and Prolonged Recovery of Cardiac Function. Journal of clinical medicine. 2024. 13. 11
2020 - 2024/05 University of Toyama Faculty of Medicine School of Medicine
2018 - 富山大学附属病院 周産母子センター 特命講師
2012 - 富山大学附属病院 小児科 助教
2010 - シンシナティ小児医療センター 循環器科 研究員
2007 - 富山大学附属病院 周産母子センター 助教
2003 - 国立循環器病センター 小児科 専門修練医
1998 - 富山医科薬科大学附属病院 小児科 研修医
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Awards (5):
2020 - 公益信託循環器学研究振興基金(褒賞内田賞)
2019 - Circulation Journal Award 2018 Clinical investigation部門 First Place賞
2015 - Miyata Foundation Award日本小児循環器学会研究奨励賞
2015 - 日本小児循環器学会Case Report Award
2006 - 日本心臓病学会Young Investigator Award賞
Association Membership(s) (12):
日本心エコー図学会
, 日本心不全学会
, European Society of Cardiology
, American Heart Association
, The American Society of Human Genetics
, 日本小児心筋疾患学会
, 日本成人先天性心疾患学会
, 日本川崎病学会
, 日本人類遺伝学会
, 日本循環器学会
, 日本小児循環器学会
, 日本小児科学会