Rchr
J-GLOBAL ID：201801018622070620   Update date: Mar. 08, 2024

Sasaki Fumiyuki

ササキ フミユキ | Sasaki Fumiyuki
Affiliation and department：
Nippon Medical School Department of Microbiology and Immunology

About Nippon Medical School Department of Microbiology and Immunology


Job title： Assistant professor
Other affiliations (1)：
Research field  (5)： Immunology ,  Pathobiochemistry ,  Sports science ,  Nutrition and health science ,  Biomedical engineering
Research keywords  (7)： 炎症 ,  免疫応答 ,  インフラマソーム ,  メカノバイオロジー ,  生理活性脂質 ,  脂質代謝 ,  Gタンパク質共役型受容体(GPCR)
Research theme for competitive and other funds  (3)：
  • 2022 - 2027 Identification and functional analysis of a novel skeletal muscle-specific mechanical stress receptor in controlling the inflammatory and immune responses
  • 2022 - 2025 エンドサイトーシスによるNLRP3インフラマソーム形成制御機構と生理的意義の解明
  • 2019 - 2021 Identification of an osteocyte-specific mechanical stress receptor by the novel screening method
Papers (14)：
  • Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, et al. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cellular & Molecular Immunology. 2021. 18. 6. 1437-1449
  • Fumiyuki Sasaki, Mikihito Hayashi, Yuki Mouri, Satoshi Nakamura, Taiji Adachi, Tomoki Nakashima. Mechanotransduction via the Piezo1-Akt pathway underlies Sost suppression in osteocytes. Biochemical and Biophysical Research Communications. 2020. 521. 3. 806-813
  • Masamu Inoue, Takehito Ono, Yoshitaka Kameo, Fumiyuki Sasaki, Takashi Ono, Taiji Adachi, Tomoki Nakashima. Forceful mastication activates osteocytes and builds a stout jawbone. Scientific Reports. 2019. 9. 1. 4404-4404
  • Takahiro Nagatake, So-ichiro Hirata, Tomoaki Koga, Etsushi Kuroda, Shingo Kobari, Hidehiko Suzuki, Koji Hosomi, Naomi Matsumoto, Yaulia Yanrismet, Michiko Shimojou, et al. BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Mucosal Immunology. 2019. 12. 5. 1082-1091
  • Fumiyuki Sasaki, Tomoaki Koga, Mai Ohba, Kazuko Saeki, Toshiaki Okuno, Keijiro Ishikawa, Takahito Nakama, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi, et al. Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight. 2018. 3. 18
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MISC (14)：
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Patents (1)：
  • 加齢黄斑変性症予防治療剤
Books (1)：
  • Bioactive lipid mediators : current reviews and protocols
    Springer 2015 ISBN:4431556680
Lectures and oral presentations  (30)：
  • Sphingosine-1-phosphate lyase SGPL1 is required for NLRP3 inflammasome activation via the dynamic organization of endoplasmic reticulum and microtubules
    (2024)
  • スフィンゴシン1リン酸分解酵素は小胞体-微小管ダイナミクスの制御を介してNLRP3インフラマソームの活性化を促進する
    (第96回日本生化学会大会, 福岡 2023)
  • Sphingosine-1-phosphate lyase promotes NLRP3 inflammasome activation via the development of endoplasmic reticulum and microtubules
    (Keystone Symposia, Innate Immunity: From Innate Sensing to Adaptive Responses, US, UT, Snowbird 2023)
  • Sphingosine-1-phosphate lyase promotes inflammasome activation via the development of endoplasmic reticulum network
    (2022)
  • ロイコトリエンB4産生経路およびロイコトリエンB4受容体BLT1は滲出型加齢黄斑変性症の新規治療標的となる(ポスター発表)
    (第40回日本炎症・再生医学会, 神戸 2019)
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Education (5)：
  • 2013 - 2013 九州大学大学院 医学系学府 医学専攻 博士(医学) 学位取得
  • 2009 - 2013 Kyushu University
  • 2007 - 2009 Kyushu University
  • 2005 - 2007 Hirosaki University Faculty of Agriculture and Life Science
  • 2000 - 2005 Tomakomai National College of Technology
Professional career (2)：
  • Doctor of Philosophy in Medicine (Kyushu University)
  • Master's degree in Medical Science (Kyushu University)
Work history (9)：
  • 2022/09 - 現在 Nippon Medical School Graduate School
  • 2021/11 - 現在 Juntendo University School of Medicine Department of Biochemistry
  • 2021/04 - 現在 Nippon Medical School Department of Microbiology and Immunology Assistant professor
  • 2017/08 - 2021/03 AMED-CREST 「骨恒常性を司る骨細胞のメカノ・カスケードの解明」 プロジェクト研究員
  • 2017/08 - 2021/03 Tokyo Medical and Dental University Department of Cell Signaling, Graduate School of Medical and Dental Sciences Project Researcher
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Committee career (1)：
  • 2023/09 - 現在 Frontiers In Immunology Review Editor
Awards (8)：
  • 2023/11 - 2022年度 公益財団法人 今井精一記念財団 研究助成 採択
  • 2023/03 - 2023年度 日本免疫学会 Tadamitsu Kishimoto International Travel Award 受賞
  • 2022/12 - The 51st Annual Meeting of the Japanese Society for Immunology Best Poster Award Sphingosine-1-phosphate lyase promotes inflammasome activation via the development of endoplasmic reticulum network
  • 2022/09 - 2022年度 公益財団法人 持田記念医学薬学振興財団 研究助成 採択
  • 2021/12 - 2021年度 神澤医学研究振興財団 研究助成 採択
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Association Membership(s) (4)：
The Japanese Society of Inflammation and Regeneration ,  The Japanese Conference on the Biochemistry of Lipids ,  Japanease Society for Immunology ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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