Koike Hiroyuki

コイケヒロユキ | Koike Hiroyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www.researchgate.net/profile/Hiroyuki-Koike-3

Research field (3)： Developmental biology , Medical biochemistry , Developmental biology

Research keywords (10)： Organoid , Single Cell Analysis , iPS Cells , Organogenesis , Aging , Liver , Macrophages , 3D Cell Culture , Stem Cell Biology , Regenerative Medicine

Research theme for competitive and other funds (11)：

2024 - 2027 マクロファージ亜集団を介した骨格筋再生制御機序の解明
2023 - 2026 疾患特異的iPS細胞を用いたケロイドの病態解明と治療法の確立
2023 - 2026 Tokyo Medical and Dental University
2022 - 2025 Establishment of a circulating culture system using the metabolic characteristics of organoids
2021 - 2024 高度オルガノイド技術を利用した革新的がん遺伝子治療モデリングと腫瘍溶解性機構解明

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Papers (31)：

Kohei Otomo, Takaki Omura, Yuki Nozawa, Steven J. Edwards, Yukihiko Sato, Yuri Saito, Shigehiro Yagishita, Hitoshi Uchida, Yuki Watakabe, Kiyotada Naitou, et al. descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Nature Communications. 2024. 15. 1
Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Takashi Matsuzaka, Hitoshi Ozawa, et al. Macrophage SREBP1 regulates skeletal muscle regeneration. Frontiers in Immunology. 2024. 14
Takahisa Matsuzaki, Yuma Kawano, Momoka Horikiri, Yuko Shimokawa, Takashi Yamazaki, Nao Okuma, Hiroyuki Koike, Masaki Kimura, Ryuzo Kawamura, Yosuke Yoneyama, et al. Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells. STAR Protocols. 2023. 4. 3. 102471-102471
Aiko Watanabe, Hiroyuki Koike, Naoki Kumagami, Shigeki Shimba, Ichiro Manabe, Yumiko Oishi. Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair. Scientific Reports. 2023. 13. 1. 6747
Rie Ouchi, Hiroyuki Koike. Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids. Frontiers in Cell and Developmental Biology. 2023. 11

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MISC (42)：

大石由美子, 小池博之. フレイル、サルコペニアのバイオマーカー加齢による筋損傷後再生不全のメカニズム. 日本老年医学会雑誌. 2022. 59. Suppl. 49-49
Hiroyuki Koike, Yumiko Oishi. Vitamin A derivative inhibits KLF5 function in the skeletal muscle atrophy pathogenesis. Experimental Medicine. 2022. 40. 7. 1027-1031
小池博之. 骨格筋再生を主導する多細胞間相互作用ネットワークの解析. 日本応用酵素協会誌. 2022. 56. 79-80
渡辺藍子, 小池博之, 大石由美子. 骨髄球系細胞が持つ細胞内時計の錯乱が筋再生に及ぼす影響. 日本筋学会学術集会プログラム・抄録集. 2021. 7回. 116-116
佐藤荘, 小池博之, 伊藤美菜子, 北岡志保, 住田智一, 増田隆博. 生体恒常性および疾患を制御する間質細胞生物学. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [JB2-1]

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Patents (3)：

Liver Organoid Compositions and Methods of Making and Using Same
Hepato-Biliary-Pancreatic Tissues and Methods of Making Same
Method for Amplifying Cell Using Amino Acid Preparation

Books (2)：

Reviews in Cell Biology and Molecular Medicine
Wiley-VCH Verlag 2016 ISBN:9783527305421
Hyper bio assembler for 3D cellular systems
Springer Japan 2015 ISBN:9784431552963

Lectures and oral presentations (65)：

Cell-cell interactions of post-injury muscle regeneration and tissue repair
(From basic discovery to preclinical modeling: at the forefront of muscle disease therapies 2023)
転写因子KLF5による筋委縮の制御と新規治療への展開
(第8回日本筋学会学術集会 2022)
加齢による筋損傷後再生不全のメカニズム
(第64回日本老年医学会学術集会 2022)
Effects of disruption of the circadian rhythm in myeloid cells on skeletal muscle regeneration
(The 7th Annual Meeting of Japan Muscle Society 2021)
SREBP1a in macrophage regulates tumor growth
(The 44th Annual Meeting of the Molecular Biology Society of Japan 2021)

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Education (3)：

2010 - 2014 Yokohama City University Graduate School of Medicine Department of Regenerative Medicine
2007 - 2009 Tohoku University Graduate School of Engineering Department of Biomolecular Engineering
2003 - 2007 Tohoku University School of Engineering Department of Applied Chemistry

Professional career (1)：

Ph.D. (Yokohama City University)

Work history (9)：

2024/10 - 現在 Institute of Sciecne Tokyo Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences Associated Professor
2023/07 - 2024/09 Tokyo Medical and Dental University Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences Associate Professor
2022/04 - 2023/06 Nippon Medical School Department of Metabolism and Nutrition, Graduate School of Medicine Senior Assistant Professor
2022/04 - 2023/06 Nippon Medical School Department of Biochemistry and Molecular Biology Senior Assistant Professor
2019/04 - 2022/03 Nippon Medical School Department of Biochemistry and Molecular Biology Assistant Professor

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Awards (8)：

2020/11 - The Takeda Science Foundation Medical Research Grant Analysis of cell-cell interactions leading to skeletal muscle regeneration using single-cell analysis
2020/06 - Japan Foundation for Applied Enzymology TMFC Analysis of the multicellular interaction network that drives skeletal muscle regeneration
2019/09 - Nippon Medical School Maruyama Memorial Research Award Elucidation of the regulatory mechanism of muscle regeneration by crosstalk between immune cells and skeletal muscle stem cells
2018/09 - Tokyo Medical and Dental University President’s Young Researchers Award Construction of an in vitro skeletal muscle injury model that can analyze the tissue repair process
2016/08 - Cincinnati Children’s Hospital Medical Center Core Values Award

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Association Membership(s) (2)：

The Molecular Biology Society of Japan , Japanese Society of Anti-Aging Medicine

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