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J-GLOBAL ID:201801018711215616   Update date: Apr. 03, 2025

Sunagawa Yoichi

Sunagawa Yoichi
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Affiliation and department:
Other affiliations (1):
  • 京都医療センター 展開医療研究部  研究員
Research field  (3): Molecular biology ,  Cardiology ,  Pharmaceuticals - health and biochemistry
Research keywords  (6): Nuclear Signaling pathway ,  Nobiletin ,  Curcumin ,  天然化合物 ,  心血管疾患 ,  分子生物学
Research theme for competitive and other funds  (12):
  • 2023 - 2026 The studyon of p300 complex on cardiac hypertrophy and fibrosis during the development of heart failure
  • 2023 - 2026 ノックインマウスを用いた心不全によるGATA4多量体形成の変化並びに治療薬の探索研究
  • 2020 - 2023 Identification and functional analysis of p300 regulatory factors involved in the development of heart failure using medical proteomics
  • 2019 - 2022 The study of functional mechanism of Nobiletin, which possess the therapeutic potency for development of heart failure.
  • 2017 - 2019 Development of novel therapeutic method for heart failure targeted on PRMT5/MEP50 complex
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Papers (225):
  • Yoichi Sunagawa, Sonoka Iwashimizu, Masaya Ono, Saho Mochizuki, Kenshiro Iwashita, Rina Sato, Satoshi Shimizu, Masafumi Funamoto, Kana Shimizu, Toshihide Hamabe-Horiike, et al. The Citrus Flavonoid Nobiletin Prevents the Development of Doxorubicin-induced Heart Failure by Inhibiting Apoptosis. Journal of Pharmacological Sciences. 2025
  • Yasufumi Katanasaka, Harumi Yabe, Noriyuki Murata, Minori Sobukawa, Yuga Sugiyama, Hikaru Sato, Hiroki Honda, Yoichi Sunagawa, Masafumi Funamoto, Satoshi Shimizu, et al. Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice. Nature communications. 2024. 15. 1. 2472-2472
  • 山本 みずほ, 砂川 陽一, 上原 渉, 船本 雅文, 刀坂 泰史, 浜辺 俊秀, 川瀬 裕斗, 鳴田 竜也, ホーク フィリップ, 小見山 麻紀, et al. A485, a Small Molecule Inhibitor of p300/CBP Histone Acetyltransferase, Ameliorates Pressure Overload-induced Cardiac Dysfunction in Mice(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ098-4
  • 川瀬 裕斗, 砂川 陽一, 船本 雅文, 刀坂 泰史, 浜辺 俊秀, 長谷川 浩二, 森本 達也. 6-shogaol, a Ginger Extract, Improves Pressure Overload-induced Systolic Dysfunction through the Inhibition of p300-HAT Activity(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ101-6
  • Yoichi Sunagawa, Ryosuke Tsukabe, Yudai Irokawa, Masafumi Funamoto, Yuto Suzuki, Miho Yamada, Satoshi Shimizu, Yasufumi Katanasaka, Toshihide Hamabe-Horiike, Yuto Kawase, et al. Anserine, a Histidine-Containing Dipeptide, Suppresses Pressure Overload-Induced Systolic Dysfunction by Inhibiting Histone Acetyltransferase Activity of p300 in Mice. International Journal of Molecular Sciences. 2024. 25. 4. 2344-2344
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MISC (454):
  • 高橋寧音, 川瀬裕斗, 平子裕太, 鳴田竜也, 船本雅文, 船本雅文, 砂川陽一, 砂川陽一, 砂川陽一, 刀坂泰史, et al. 天然物サンショウの抽出物であるCompound Xは心筋細胞肥大を抑制した. 日本薬理学雑誌. 2024. 159. Supplement
  • 坂侑子, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 前川健也, 川瀬裕斗, 鳴田竜也, 浜辺俊秀, et al. オオイタドリ若芽エキスはラット心筋梗塞モデルの収縮能の低下を改善した. 日本栄養・食糧学会中部支部大会講演要旨集. 2024. 83rd (CD-ROM)
  • 川瀬裕斗, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 刀坂泰史, 刀坂泰史, 刀坂泰史, 浜辺俊秀, et al. 6-shogaol, a Ginger Extract, Improves Pressure Overload-induced Systolic Dysfunction through the Inhibition of p300-HAT Activity. 日本循環器学会学術集会(Web). 2024. 88th
  • 山本みずほ, 砂川陽一, 砂川陽一, 砂川陽一, 上原渉, 船本雅文, 船本雅文, 刀坂泰史, 刀坂泰史, 刀坂泰史, et al. A485, a Small Molecule Inhibitor of p300/CBP Histone Acetyltransferase, Ameliorates Pressure Overload-induced Cardiac Dysfunction in Mice. 日本循環器学会学術集会(Web). 2024. 88th
  • 須藤優, 高井秀通, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 川瀬裕斗, 鳴田竜也, 刀坂泰史, et al. The novel Curcumin formulation curcuRouge inhibits systolic dysfunction in myocardial infarction model rats. 日本薬学会年会要旨集(Web). 2024. 144th
more...
Books (4):
  • 心不全(第2版) 上巻
    日本臨牀 2018
  • 機能性表示食品DATA BOOK
    日本抗加齢協会 メディカルビュー社 2017
  • 日本抗加齢医学会雑誌
    日本抗加齢医学会 2015
  • Functional Food
    2015
Education (3):
  • 2009 - 2012 Kyoto University School of Medicine and Faculty of Medicine Human Health Science
  • 2004 - 2006 Osaka Prefecture University
  • 2000 - 2004 Osaka Prefecture University
Professional career (1):
  • 人間健康学 (京都大学)
Work history (6):
  • 2021/10 - 現在 University of Shizuoka Divison of Molecular Medicine, School of Pharmaceutical Sciences
  • 2014/08 - 現在 University of Shizuoka School of Pharmaceutical Sciences Research Assistant
  • 2013/08 - 2014/07 Kyoto Medical Center Department of Translational Research
  • 2012/04 - 2013/07 University of Shizuoka School of Pharmaceutical Sciences Post Doctor
  • 2009/04 - 2012/03 Kyoto University Graduate school of Medicine and Faculty of Medicine, Division of Human Health Sciences
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Awards (7):
  • 2018/07 - 日本薬学会東海支部 平成30年度学術奨励賞 食品由来天然化合物を用いた心血管疾患薬物治療に関する研究
  • 2017/05 - 第3回国際心血管薬物療法学会日本部会 研究奨励賞 心筋細胞肥大の過程におけるGATA4のリン酸化とアセチル化のクロストークについて
  • 2015/05 - The XVIIth International Congress of the International Society of Cardiovascular Pharmacotherapy YIA First Prize Auraptene, a Coumaric Compounds analogous, Prevented Cardiac Hypertrophy by Activating PPARα After Myocardial Infarction in Rats
  • 2014/10 - Young Investigator Award Auraptene, a Coumaric Compounds analogous, Improved the Worsening of Systolic Function by Activating Mitochondrial Function After Myocardial Infarction in Rats
  • 2012/05 - The XVIIth International Congress of the International Society of Cardiovascular Pharmacotherapy YIA First Prize Curcumin, a p300 HAT Inhibitor, Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats
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Association Membership(s) (7):
Japan society of Nutrition and Food Science ,  JAPANESE HEART FAILURE SOCIETY ,  Anti-Aging Society of Japan ,  International Congress of the International Society of Cardiovascular Pharmacotherapy, Japan section ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  The Japanese Circulation Society
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