Sunagawa Yoichi

Affiliation and department：
Other affiliations (1)：

京都医療センター展開医療研究部研究員

Research field (3)： Molecular biology , Cardiology , Pharmaceuticals - health and biochemistry

Research keywords (6)： Nuclear Signaling pathway , Nobiletin , Curcumin , 天然化合物 , 心血管疾患 , 分子生物学

Research theme for competitive and other funds (9)：

2023 - 2026 The studyon of p300 complex on cardiac hypertrophy and fibrosis during the development of heart failure
2023 - 2026 ノックインマウスを用いた心不全によるGATA4多量体形成の変化並びに治療薬の探索研究
2020 - 2023 Identification and functional analysis of p300 regulatory factors involved in the development of heart failure using medical proteomics
2019 - 2022 The study of functional mechanism of Nobiletin, which possess the therapeutic potency for development of heart failure.
2017 - 2019 Development of novel therapeutic method for heart failure targeted on PRMT5/MEP50 complex

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Papers (218)：

Yasufumi Katanasaka, Harumi Yabe, Noriyuki Murata, Minori Sobukawa, Yuga Sugiyama, Hikaru Sato, Hiroki Honda, Yoichi Sunagawa, Masafumi Funamoto, Satoshi Shimizu, et al. Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice. Nature communications. 2024. 15. 1. 2472-2472
Yoichi Sunagawa, Ryosuke Tsukabe, Yudai Irokawa, Masafumi Funamoto, Yuto Suzuki, Miho Yamada, Satoshi Shimizu, Yasufumi Katanasaka, Toshihide Hamabe-Horiike, Yuto Kawase, et al. Anserine, a Histidine-Containing Dipeptide, Suppresses Pressure Overload-Induced Systolic Dysfunction by Inhibiting Histone Acetyltransferase Activity of p300 in Mice. International Journal of Molecular Sciences. 2024. 25. 4. 2344-2344
Swati Mittal, Maki Komiyama, Yuka Ozaki, Hajime Yamakage, Noriko Satoh-Asahara, Hiromichi Wada, Akihiro Yasoda, Masafumi Funamoto, Yasufumi Katanasaka, Yoichi Sunagawa, et al. Impact of smoking initiation age on nicotine dependency and cardiovascular risk factors: a retrospective cohort study in Japan. European heart journal open. 2024. 4. 1. oead135
色川雄大, 砂川陽一, 山田美帆, 片桐宇大, 前川健也, 清水聡史, 刀坂泰史, 浜辺俊秀, 川瀬裕斗, 鳴田竜也, et al. ヒスチジン含有ジペプチドのアンセリンはp300-HAT活性を阻害することにより、心筋細胞肥大および圧負荷モデルマウスの心収縮能低下を抑制した. 日本統合医療学会誌. 2023. 16. 3. 219-219
高橋寧音, 川瀬裕斗, 平子裕太, 鳴田竜也, 船本雅文, 砂川陽一, 刀坂泰史, 浜辺俊秀, 小見山麻紀, 長谷川浩二, et al. 天然物サンショウの抽出物であるCompound Xは心筋細胞肥大を抑制した. 日本統合医療学会誌. 2023. 16. 3. 227-227

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MISC (448)：

色川雄大, 砂川陽一, 砂川陽一, 砂川陽一, 山田美帆, 片桐宇大, 前川健也, 清水聡史, 清水聡史, 刀坂泰史, et al. ヒスチジン含有ジペプチドであるアンセリンは心筋細胞肥大および圧負荷モデルマウスの心収縮能低下を抑制した. 日本循環薬理学会口演要旨集. 2024. 33rd
須藤優, 塚部凌輔, 川瀬裕斗, 清水聡史, 清水聡史, 浜辺俊秀, 浜辺俊秀, 砂川陽一, 砂川陽一, 砂川陽一, et al. 転写因子GATA4の多量体形成阻害は心筋細胞肥大を抑制した. 日本薬理学雑誌. 2023. 158. Supplement
前田莉沙, 清水聡史, 砂川陽一, 砂川陽一, 砂川陽一, 浜辺俊秀, 浜辺俊秀, 浜辺俊秀, 刀坂泰史, 刀坂泰史, et al. High throughput screening assayにより同定したRFN-409は圧負荷による左室収縮能低下を改善した. 日本薬理学雑誌. 2023. 158. Supplement
鈴木悠斗, 砂川陽一, 砂川陽一, 砂川陽一, 石間彩花, 浜辺俊秀, 浜辺俊秀, 浜辺俊秀, 刀坂泰史, 刀坂泰史, et al. 心臓特異的p300-BP1ノックアウトは圧負荷による心筋肥大及び心不全の進展を軽減させた. 日本薬理学雑誌. 2023. 158. Supplement
上原渉, 船本雅文, 船本雅文, 船本雅文, 山本みずほ, 砂川陽一, 砂川陽一, 砂川陽一, 刀坂泰史, 刀坂泰史, et al. The BRG1 inhibitor Suppressed Pressure Overload-induced Systolic Dysfunction in Mice. 日本薬学会年会要旨集(Web). 2023. 143rd

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Books (4)：

心不全(第2版) 上巻
日本臨牀 2018
機能性表示食品DATA BOOK
日本抗加齢協会メディカルビュー社 2017
日本抗加齢医学会雑誌
日本抗加齢医学会 2015
Functional Food
2015

Education (3)：

2009 - 2012 Kyoto University School of Medicine and Faculty of Medicine Human Health Science
2004 - 2006 Osaka Prefecture University
2000 - 2004 Osaka Prefecture University

Professional career (1)：

人間健康学 (京都大学)

Work history (6)：

2021/10 - 現在 University of Shizuoka Divison of Molecular Medicine, School of Pharmaceutical Sciences
2014/08 - 現在 University of Shizuoka School of Pharmaceutical Sciences Research Assistant
2013/08 - 2014/07 Kyoto Medical Center Department of Translational Research
2012/04 - 2013/07 University of Shizuoka School of Pharmaceutical Sciences Post Doctor
2009/04 - 2012/03 Kyoto University Graduate school of Medicine and Faculty of Medicine, Division of Human Health Sciences

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Awards (7)：

2018/07 - 日本薬学会東海支部平成30年度学術奨励賞食品由来天然化合物を用いた心血管疾患薬物治療に関する研究
2017/05 - 第3回国際心血管薬物療法学会日本部会研究奨励賞心筋細胞肥大の過程におけるGATA4のリン酸化とアセチル化のクロストークについて
2015/05 - The XVIIth International Congress of the International Society of Cardiovascular Pharmacotherapy YIA First Prize Auraptene, a Coumaric Compounds analogous, Prevented Cardiac Hypertrophy by Activating PPARα After Myocardial Infarction in Rats
2014/10 - Young Investigator Award Auraptene, a Coumaric Compounds analogous, Improved the Worsening of Systolic Function by Activating Mitochondrial Function After Myocardial Infarction in Rats
2012/05 - The XVIIth International Congress of the International Society of Cardiovascular Pharmacotherapy YIA First Prize Curcumin, a p300 HAT Inhibitor, Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats

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Association Membership(s) (7)：

Japan society of Nutrition and Food Science , JAPANESE HEART FAILURE SOCIETY , Anti-Aging Society of Japan , International Congress of the International Society of Cardiovascular Pharmacotherapy, Japan section , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , The Japanese Circulation Society

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