2019 - 2022 Development of angiogenic microRNA-contained exosomes for angiogenesis therapy
2019 - 2022 Development of vascular regeneration therapy by exosome derived from enhanced cells
2019 - 2021 Development of exosomes accumulating in ischemic tissues for angiogenesis
2018 - 2021 Elucidation of the role of RNA-modifying enzymes in anticancer drug-resistant non-small cell lung cancer
2018 - 2021 Development of methods to reduce spinal cord ischemia-reperfusion disorder by exosomes
2018 - 2021 Development of cryopreservation method for allogeneic cell sheet
2017 - 2020 Development of regenerative therapy for refractory cutaneous ulcers using multi-layered cell sheets
2017 - 2019 Development of angiogenesis therapy by microRNA expressed in mice with angiogenic ability
2016 - 2019 Development of regenerative medicine for refractory skin ulcers using fibroblasts
2015 - 2018 Development of transplantation therapy using hypoxically preconditioned cell sheets for lower limb ischemic ulcers
2015 - 2017 Analysis of extracellular microRNA having protective effects against ischemia-perfusion injury of organs after ischemic preconditioning
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Papers (72):
Koji Ueno, Hiroshi Kurazumi, Ryo Suzuki, Masashi Yanagihara, Takahiro Mizoguchi, Takasuke Harada, Noriyasu Morikage, Kimikazu Hamano. miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation. Scientific reports. 2024. 14. 1. 11372-11372
Masashi Yanagihara, Yutaro Matsuno, Koji Ueno, Hiroshi Kurazumi, Ryo Suzuki, Toshiki Tanaka, Kimikazu Hamano. Fibroblasts are the most suitable cell source for regenerative medicine due to their high intracellular fibroblast growth factor 2 content. Biochemistry and biophysics reports. 2023. 35. 101510-101510
Sota Yoshimine, Toshiki Tanaka, Junichi Murakami, Naohiro Yamamoto, Koji Ueno, Hiroshi Kurazumi, Eiji Ikeda, Kimikazu Hamano. Postoperative changes in bronchial stump following covering with free fat tissue in a rat model. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2023
Naohiro Yamamoto, Koji Ueno, Masashi Yanagihara, Hiroshi Kurazumi, Yuya Tanaka, Atsunori Oga, Mototsugu Shimokawa, Eijiro Harada, Toshiki Tanaka, Kimikazu Hamano. Allogenic multilayered fibroblast sheets promote anastomotic site healing in a rat model of esophageal reconstruction. American journal of translational research. 2023. 15. 5. 3217-3228
Yutaro Matsuno, Masashi Yanagihara, Koji Ueno, Toshiro Saito, Hiroshi Kurazumi, Ryo Suzuki, Shunsaku Katsura, Atsunori Oga, Kimikazu Hamano. Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing. Scientific Reports. 2022. 12. 1. 12519-12519