Matsumoto Yuka

マツモトユカ | Matsumoto Yuka

Affiliation and department：

Research field (1)： Gastroenterology

Research theme for competitive and other funds (7)：

2022 - 2026 Development of technology for in vivo intestinal engineering by transplantation of organoids after epithelial removal by using newly-synthesized chelating agents.
2021 - 2023 Development of novel treatment strategy for intestinal failure based on generation and transplantation of intestinal organoids capable of GLP-2 secretion in an inducible manner
2020 - 2022 Development of novel technology for intestinal epithelial replacement with urothelial organoids and its implementation in bladder augmentation
2019 - 2022 Study of the small intestine reproduction with the bowels epithelium organoid and the bloodstream preservation Biotube
2019 - 2022 Regenerative potential of human infant small intestinal organoids obtained from surgical specimens

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Papers (12)：

Kazuto Suda, Yuka Matsumoto, Takanori Ochi, Hiroyuki Koga, Nobutaka Hattori, Atsuyuki Yamataka, Tetsuya Nakamura. Distinct effects of Fgf7 and Fgf10 on the terminal differentiation of murine bladder urothelium revealed using an organoid culture system. BMC Urology. 2023. 23. 1
須田一人, 松本有加, 越智崇徳, 古賀寛之, 中村哲也, 山高篤行. 再生医療のup to date 結腸への膀胱上皮オルガノイド移植腸管利用膀胱拡大術後の癌発生予防. 日本小児外科学会雑誌. 2023. 59. 3. 407-407
松本有加, 須田一人, 山高篤行, 中村哲也. 腸上皮剥離後置換による腸管不全治療に向けた新規高分子キレート剤の毒性と有効性評価. 日本小児外科学会雑誌. 2023. 59. 3. 482-482
Kazuto Suda, Yuka Matsumoto, Takanori Ochi, Hiroyuki Koga, Geoffrey J Lane, Nobutaka Hattori, Tetsuya Nakamura, Atsuyuki Yamataka. Successful engraftment of bladder organoids in de-epithelialized mouse colon. Pediatric surgery international. 2022. 39. 1. 14-14
Yuka Matsumoto, Hiroyuki Koga, Mirei Takahashi, Kazuto Suda, Takanori Ochi, Shogo Seo, Go Miyano, Yuichiro Miyake, Hideaki Nakajima, Shiho Yoshida, et al. Defined serum-free culture of human infant small intestinal organoids with predetermined doses of Wnt3a and R-spondin1 from surgical specimens. Pediatric Surgery International. 2021. 37. 11. 1543-1554

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MISC (3)：

松本有加, 須田一人, 古賀寛之, 山高篤行, 中村哲也. 短腸症候群の診療における問題点大腸への小腸オルガノイド移植による腸管不全治療の開発. 小児外科. 2022. 54. 3
Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura. Retinol stimulates proliferation of proximal colon stem cells through a retinoic acid-independent mechanism. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2016. 31. 145-145
Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura. Retinol Stimulates Proliferation of Epithelial Stem Cells of the Proximal Colon Through a Retinoic Acid-Independent Mechanism. GASTROENTEROLOGY. 2016. 150. 4. S297-S297

Lectures and oral presentations (6)：

小腸オルガノイド移植による大腸上皮置換技術を用いた小腸機能不全治療の開発
(第57回日本小児外科学会学術集会 2020)
オルガノイド移植による大腸上皮置換術の確立と移植上皮の網羅的遺伝子発現解析
(第19回日本再生医療学会総会)
大腸への小腸上皮オルガノイド移植による腸管不全治療技術開発
(第120回日本外科学会学術集会 2020)
大腸への小腸上皮オルガノイド移植技術開発と移植片の性状解析
(第18回日本再生医療学会総会 2019)
Development of a new mouse model of short bowel syndrome that may allow for the assessment of therapeutic efficacy of heterotopic transplantation of small intestinal organoids
(5th TERMIS World Congress 2018)

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Work history (9)：

2021/05/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences - - Visiting Lecturer
2020/05/01 - 現在 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Internal Medicine Gastroenterology and Hepatology Visiting Lecturer
2019/05 - 現在順天堂大学順天堂医院小児外科・小児泌尿生殖器外科助教
2020/05/01 - 2021/04/30 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Internal Medicine Gastroenterology and Hepatology Visiting Lecturer
2019/06/01 - 2020/03/31 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Internal Medicine Gastroenterology and Hepatology Visiting Lecturer

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Awards (1)：

2019/04 - 令和元年度文部科学省科学研究費補助金基盤研究(C):19K07500 in vivoイメージングを組合せた腸上皮治癒過程での細胞脱分化機構解明研究代表者:松本有加研究分担者:中村哲也 in vivoイメージングを組合せた腸上皮治癒過程での細胞脱分化機構解明

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