Rchr
J-GLOBAL ID：201801019454986386
Update date: Jul. 15, 2024
Nishimura Hitoshi
ニシムラ ヒトシ | Nishimura Hitoshi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.setsunan.ac.jp/
Research field (1)：
Developmental biology
Research keywords (1)：
受精,精子形成,ゲノム編集,線虫,マウス
Research theme for competitive and other funds (21)：
- 2019 - 2022 Functional analysis of JNK-type MAPKs on C. elegans spermiogenesis
- 2020 - 2021 男性不妊薬を指向した精子の受精能獲得を惹起する薬剤の創生
- 2012 - 2015 Identification of gamete fusion-related factors that are present on the oocyte surface
- 2012 - 2014 線虫と哺乳類に共通するアロ認証機構の解析
- 2011 - 2013 線虫と哺乳類精子に存在する免疫グロブリン様タンパク質を含む配偶子間融合装置の同定
- 2007 - Study on the mechanism for C. elegans reproduction
- 2001 - 2002 細菌感染に対するヒト抗菌蛋白質BPIを介した自然免疫系の研究
- 2000 - 2002 Studies on the Regulation of Fertilization and Activation of Development
- 1999 - 2002 Molecular Mechanism of Functional Regulation of Spermatiogenic Cells by Interaction with Other Somatic Cells and Eggs
- 2001 - 2001 精巣特異的なADAM遺伝子ファミリーの機能解析
- 2000 - 2001 ヒト好中球由来抗菌タンパク質BPIを介した大腸菌上での補体系活性化機構について
- 1997 - 1999 Studies on effector molecules of innate immunity responsible for cytotoxicity to tumor cells.
- 1996 - 1997 APOPTOSIS AND COMPLEMENT-STUDIES ON THE MECHANISM OF COMPKEMENT ACTIVATION AND THE BIOLOGICAL SIGNIFICANCE
- 1995 - 1996 ヒト血漿カリクレイン感受性タンパク質PK-120の機能解析
- 1996 - 1996 ヒト血漿カリクレイン感受性蛋白質PK-120の機能についての研究
- 1994 - 1996 Molecular design of low molecular fragments of complement regulatory factor for medical applications to zeno-transplantation and prevention of measles virus infection
- 1995 - 1995 ヒト血漿カリクレイン感受性蛋白質PK-120の機能解析
- 1994 - 1995 STUDIES ON THE BIOLOGICAL FUNCTIONS OF THE COMPLEMENT SYSTEM
- 1994 - 1994 ヒトIX因子(血友病B因子)のEGF様第1ドメイン内の新型糖鎖の機能解析
- 1991 - 1993 Molecular Mechanism of Extrinsic Blood Coagulation Pathway
- 1990 - 1990 血液凝固因子に見出された新型糖鎖の構造に関する研究
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Papers (40)：
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Yoshihiro Shimada, Nana Kanazawa-Takino, Hitoshi Nishimura. Spermiogenesis in Caenorhabditis elegans: An Excellent Model to Explore the Molecular Basis for Sperm Activation. Biomolecules. 2023. 13. 4. 657-657
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Jun Takayama, Tatsuya Tajima, Shuichi Onami, Hitoshi Nishimura. C. elegans spermatozoa lacking spe-45 are incapable of fusing with the oocyte plasma membrane. microPublication biology. 2021. 2021
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Yukiko Karuo, Riona Shiraki, Ayaka Yoshida, Ryo Tsunokawa, Mayuko Nakahara-Yamada, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote, Hitoshi Nishimura. Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa. Chemical & pharmaceutical bulletin. 2021. 69. 6. 557-563
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Tatsuya Tajima, Futa Ogawa, Shogo Nakamura, Masaharu Hashimoto, Masaaki Omote, Hitoshi Nishimura. Proteinase K is an activator for the male-dependent spermiogenesis pathway in Caenorhabditis elegans: Its application to pharmacological dissection of spermiogenesis. Genes to cells : devoted to molecular & cellular mechanisms. 2019. 24. 3. 244-258
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Tatsuya Tajima, Hitoshi Nishimura. Immunoglobulin-like domains have an evolutionarily conserved role during gamete fusion in C. elegans and Mouse. Origin and Evolution of Biodiversity. 2018. 163-179
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MISC (3)：
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M Matsumoto, S Kikkawa, M Nishiguchi, H Nishimura, S Nagasawa, T Seya. Complement-activating protein M161Ag is a Mycoplasma fermentans gene product that induces cytokine production by human monocytes. MOLECULAR IMMUNOLOGY. 1998. 35. 6-7. 402-402
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S Iwanaga, H Nishimura, S Kawabata, W Kisiel, S Hase, T Ikenaka. A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z. Advances in experimental medicine and biology. 1990. 281. 121-31
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H NISHIMURA, S KAWABATA, S HASE, T IKENAKA, T TAKAO, Y SHIMONISHI, W KISIEL, S IWANAGA. A NEW SUGAR CHAIN LINKED TO A SERINE RESIDUE IN THE 1ST EGF-LIKE DOMAIN OF HUMAN AND BOVINE CLOTTING FACTOR-VII, FACTOR-IX AND PROTEIN-Z. THROMBOSIS AND HAEMOSTASIS. 1989. 62. 1. 17-17
Patents (1)：
Books (6)：
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Origin and Evolution of Biodiversity
Springer 2018 ISBN:9783319959535
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凝固と炎症~新・血栓止血血管学
金芳堂 2015
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動植物の受精学-共通機構と多様性
化学同人 2014 ISBN:9784759815146
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動植物における有性生殖
スプリンガーオープン 2014
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Sexual Reproduction in animals and Plants
Springer Open 2014 ISBN:9784431545880
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Lectures and oral presentations (38)：
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線虫の精子形成における新規温度感受性経路にはtRNAメチル基転移酵素遺伝子nsun-2が関与する
(関西線虫勉強会2024 2024)
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Identification of sperm activation-related factors conserved in C. elegans and mice by using the benzylamine analog DDI-4 as a probe
(2023)
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ベンジルアミン系化合物をプローブとした線虫とマウスに共通する精子活性化因子の同定
(日本動物学会 第94回山形大会 2023)
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ベンジルアミン系化合物DDI-4をプローブとした線虫とマウスに保存されている 精子活性化機構の探索
(線虫研究の未来を創る会2023 2023)
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DDI-4 is a compound enabling to elucidate the common mechanism underlying sperm activation in C. elegans and mice
(Gordon Research Conference on Fertilization and Activation of Development 2023)
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Works (1)：
Education (4)：
- 1993 - 1993 Kyushu University
- 1990 - 1992 九州大学大学院 医学系研究科 分子生命科学系専攻,博士課程
- 1988 - 1990 九州大学大学院 理学研究科 生物学専攻,修士課程
- 1984 - 1988 Kyushu University School of Sciences Department of Biology
Work history (8)：
- 2011/04 - 現在 Setsunan University Faculty of Science and Engineering
- 2007/08 - 2011/03 Emory University Department of Biology Post-doctoral fellow
- 2006/04 - 2007/07 University of California Davis Department of Cell Biology and Human Anatomy Staff Research Associate III
- 2003/04 - 2006/03 University of California Davis Department of Cell Biology and Human Anatomy Visiting Assistant Researcher
- 2000/04 - 2003/03 University of Tsukuba
- 1998/04 - 2000/03 Japan Society for the Promotion of Science
- 1992/06 - 2000/03 Hokkaido University Faculty of Pharmaceutical Sciences
- 1991/04 - 1992/05 Japan Society for the Promotion of Science
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Awards (1)：
Association Membership(s) (4)：
全米遺伝学会
, The Molecular Biology Society of Japan
, 日本動物学会
, 日本生化学会
