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J-GLOBAL ID：201801019726368652   Update date: Mar. 07, 2025

Miki Higashi

ヒガシ ミキ | Miki Higashi
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Affiliation and department：
Nagasaki University Graduate School of Biomedical Sciences

About Nagasaki University Graduate School of Biomedical Sciences


Research field  (1)： Molecular biology
Research theme for competitive and other funds  (3)：
  • 2025 - 2027 新規再生医療開発を目指した骨格筋由来細胞シートの抗炎症効果の検証
  • 2023 - 2025 他家細胞を利用する新規再生医療開発を目指した骨格筋由来細胞の免疫応答特性の解析
  • 2022 - 2025 抗原性を消失させたユニバーサルヒト骨格筋芽細胞のセルバンキングの構築に関する研究
Papers (14)：
  • Yasuhiro Maruya, Yuko Akazawa, Kiyuu Norimatsu, Yerkezhan Sailaubekova, Nazigul Zhumagazhiyeva, Shinichiro Kobayashi, Miki Higashi, Keiichi Hashiguchi, Naoyuki Yamaguchi, Masahiro Nakashima, et al. Long-term prognosis and DNA damage status after oral mucosal epithelial cell sheet transplantation following esophageal endoscopic submucosal dissection for squamous cell carcinoma: A case series. Regenerative Therapy. 2024. 26. 557-563
  • Kengo Kanetaka, Yasuhiro Maruya, Miki Higashi, Shun Yamaguchi, Ryo Matsumoto, Shinichiro Kobayashi, Keiichi Hashiguchi, Fumiya Oohashi, Masaki Matsumura, Takahiro Naka, et al. A first-in-human clinical study of laparoscopic autologous myoblast sheet transplantation to prevent delayed perforation after duodenal endoscopic mucosal dissection. Stem Cell Research & Therapy. 2024. 15. 1
  • Shun Yamaguchi, Miki Higashi, Kengo Kanetaka, Yasuhiro Maruya, Shinichiro Kobayashi, Keiichi Hashiguchi, Masaaki Hidaka, Kazuhiko Nakao, Susumu Eguchi. Rapid and chronological expression of angiogenetic genes is a major mechanism involved in cell sheet transplantation in a rat gastric ulcer model. Regenerative Therapy. 2022. 21. 372-379
  • Shun Yamaguchi, Kengo Kanetaka, Yasuhiro Maruya, Miki Higashi, Shinichiro Kobayashi, Keiichi Hashiguchi, Fumiya Oohashi, Yusuke Sakai, Kazuhiko Nakao, Susumu Eguchi. Highly feasible procedure for laparoscopic transplantation of cell sheets under pneumoperitoneum in porcine model. Surgical Endoscopy. 2022. 36. 6. 3911-3919
  • Miki Higashi, Tsuyoshi Ikehara, Takeya Nakagawa, Mitsuhiro Yoneda, Naoko Hattori, Masaaki Ikeda, Takashi Ito. Long noncoding RNAs transcribed downstream of the human β-globin locus regulate β-globin gene expression. The Journal of Biochemistry. 2022. 171. 3. 287-294
ｍore...
MISC (3)：
  • 東 美樹, 金高 賢悟, 丸屋 安広, 江口 晋. 表在性非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術における自己骨格筋由来細胞シートの探索的治験. 再生医療. 2024. 23. 03. 18-23
  • Advancement of regenerative medicine in gastrointestinal surgery. Bio clinica. 2022. 37. 12. 1079-1083
  • 橋口 慶一, 荻原 久美, 山口 峻, 松本 亮, 東 美樹, 丸屋 安広, 小林 慎一朗, 堺 祐輔, 大仁田 賢, 金高 賢悟, et al. 消化管再生医療の基礎的・臨床的研究 自己筋芽細胞シート移植による十二指腸ESD遅発性穿孔予防の開発. 日本消化管学会雑誌. 2021. 5. Suppl. 168-168
Patents (6)：
  • 骨格筋由来細胞における制御性T細胞誘導因子の発現を誘導する方法
  • 骨格筋由来細胞における制御性T細胞誘導因子の発現を誘導する方法
  • 骨格筋由来細胞における制御性T細胞誘導因子の発現を誘導する方法
  • 骨格筋由来細胞における制御性T細胞誘導因子の発現を誘導する方法
  • 膵臓の切断面を覆うためのシート状細胞培養物
ｍore...
Lectures and oral presentations  (9)：
  • 腹腔内臓器への細胞シート医療の確立(基礎研究から医師主導治験へ)
    (第110回日本消化器病学会総会 2024)
  • A FIRST-IN-HUMAN CLINICAL STUDY OF LAPAROSCOPIC AUTOLOGOUS MYOBLAST SHEET TRANSPLANTATION TO PREVENT DELAYED PERFORATION AFTER DUODENAL ENDOSCOPIC MUCOSAL DISSECTION
    (The ISSCR 2024 Cincinnati International Symposium 2024)
  • A first-in-human clinical study of laparoscopic autologous myoblast sheet transplantation for prevention of delayed perforation after duodenal endoscopic mucosal dissection
    (2024)
  • 細胞シート医療の開発に向けてのチームビルディングの重要性
    (第22回日本再生医療学会総会 2023)
  • The novel strategy to prevent late perforation after duodenal endoscopic submucosal dissection with myoblast sheet transplantation
    (2022)
ｍore...
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