Rchr
J-GLOBAL ID：201801019925790169   Update date: Jan. 30, 2024

Toshiharu Shibuya

Toshiharu Shibuya
Affiliation and department：
Osaka University

About Osaka University


Research field  (2)： Neuropathology ,  Molecular biology
Research theme for competitive and other funds  (3)：
  • 2011 - 2012 Study of the molecular mechanism of oxidative stress response induced by mitochondrial ROS
  • 2007 - 2012 Integrated study of cell death: Biology focusing on multiple mechanisms of mammalian cell death
  • 2009 - 2010 Study of the molecular mechanism of oxidative stress response induced by mitochondrial ROS
Papers (16)：
  • Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara. RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing. Journal of Biological Chemistry. 2023. 104840-104840
  • Maal Inoue, Taisuke Nakahama, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara. An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice. Journal of immunology (Baltimore, Md. : 1950). 2021
  • Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara. Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy. Immunity. 2021. 54. 9. 1976-1988.e7
  • Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, et al. RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain. PLOS Genetics. 2021. 17. 5. e1009516-e1009516
  • Tuangtong Vongpipatana*, Taisuke Nakahama*#, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara# (Co-first author*, Corresponding author#). ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways. Journal of immunology (Baltimore, Md. : 1950). 2020. 204. 8. 2156-2168
ｍore...
MISC (4)：
  • Okazuaki Tokunaga, Toshiharu Shibuya, Tokio Tani. Nuclear mRNA export is coupled to ongoing gene transcription. CELL STRUCTURE AND FUNCTION. 2004. 29. 68-68
  • H Tadakuma, T Shibuya, Y Ishihama, T Tani, T Funatsu. Imaging of single mRNA molecules moving within a nucleus of living cells. BIOPHYSICAL JOURNAL. 2003. 84. 2. 299A-299A
  • H Tadakuma, T Shibuya, Y Ishihama, J Atoh, Y Habara, T Tani, T Funatsu. Imaging of single mRNA molecules moving within a nucleus of living cells. BIOPHYSICAL JOURNAL. 2001. 80. 1. 148A-148A
  • SHIBUYA Toshiharu, TSUNEYOSHI Satomi, URUSHIYAMA Seiichi, TANI Tokio, OHSHIMA Yasumi. The ptr6^+ gene required for mRNA export in fission yeast encodes a homologue of human TAF_<II> and yeast TAF_<II>67. 1998. 21. 449-449
Education (3)：
  • 1999 - 2002 Kyushu University
  • 1997 - 1999 Kyushu University
  • 1993 - 1997 Kyushu University School of Sciences Department of Biology
Work history (4)：
  • 2015/04 - 現在 Osaka University Graduate School of Medicine
  • 2006/11 - 2015/03 Osaka University Graduate School of Medicine
  • 2006/01 - 2006/09 産業技術総合研究所 機能性RNA解析グループ ポスドク研究員
  • 2002/06 - 2005/12 Brandeis University Biochemistry ポスドク研究員
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